Genetic Regulation Of IgE
Published 2014 · Biology
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Atopic diseases such as atopic dermatitis, allergic asthma, allergic rhinitis, and food allergy are based on genetic determinants with a reported heritability of up to 80 % (Cookson and Moffatt 2000; Vercelli 2008; Gould and Sutton 2008). Atopic diseases are typical complex, polygenic traits, which are believed to be influenced by the environment, gene–gene interactions, and multiple genetic variants. A large number of candidate gene studies have been conducted for atopic diseases, results of which were often inconsistent. The candidate genes that could be determined
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