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Retrograde Axonal Transport And Nerve Regeneration
Published 1984 · Chemistry
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The ability of neurons to take up exogenous protein molecules and to transport them in a retrograde direction (i.e., from axon to cell body) enables neuroanatomists to trace neuronal pathways (La Vail, 1978). Toxins (Mellanby and Green, 1981) and certain viruses (K. Kristensson, Chapter 3, this volume) use this route to enter the CNS. The retrograde transport of lectins (e.g., Borges and Sidman, 1982) and neurotransmitters (Streit, 1980) shows that specific components of the neuronal membrane, that is, the receptors for these ligands, are returned to the cell body where they were synthesized originally (Laduron, 1980; Laduron and Janssen, 1982). With the exception of nerve growth factor (NGF) (Schwab et al., 1981), the physiological significance of the retrograde transport of these exogenous molecules remains to be determined, but it is widely believed that the sampling of the axonal environment provided to the cell body by this process has informational significance.
This paper references
Some metabolic responses of axotomized neurones to contact between their axons and denervated muscle
W. E. Watson (1970)
Comparison of adenylate cyclase activity in segments of rat sciatic nerve with a condition/test or test lesion
R. Carlsen (1982)
Communication between target organs and nerve cells: retrograde axonal transport and site of action of nerve growth factors.
M. Schwab (1982)
Acrylamide and 2,5-hexanedione neuropathies: abnormal bidirectional transport rate in distal axons
Z. Sahenk (1981)
Axonal Transport, Deposition, and Metabolic Turnover of Glycoproteins in the Rat Optic Pathway
J. Goodrum (1982)
Position-sensitive detector studies of the axonal transport of a pulse of radioisotope.
D. W. O'Brien (1982)
Evidence against the smooth endoplasmic reticulum as a continuous channel for the retrograde axonal transport of horseradish peroxidase
J. Lavail (1980)
Acetylcholinesterase Distribution in Axotomized Frog Motoneurons
D. V. Sinicropi (1982)
Nerve growth factor effects on protein synthesis after nerve damage
M. Hall (1982)
What is the signal for chromatolysis?
B. Cragg (1970)
Current Problems of Lower Vertebrate Phylogeny.
G. J. Romanes (1969)
Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers
F. Longo (1983)
Explant culture of adult goldfish retina: A model for the study of CNS regeneration
G. Landreth (1979)
Correlation of axonal regeneration and slow component B in two branches of a single axon
J. Wujek (1983)
Early and Dose‐Dependent Decrease of Retrograde Axonal Transport in Acrylamide‐Intoxicated Rats
J. Jakobsen (1983)
Polarity of axoplasmic microtubules in the olfactory nerve of the frog.
P. Burton (1981)
Computer analysis of organelle translocation in primary neuronal cultures and continuous cell lines
A. Breuer (1975)
‘Acrylamide-induced‘ neuropathy and impairment of axonal transport of proteins. II. Abnormal accumulations of smooth endoplasmic reticulum as sites of focal retention of fast transported proteins. Electron microscope radioautographic study
M. Chretien (1981)
Neuroanatomical Research Techniques
R. Robertson (1978)
Characterization of neuritic outgrowth-promoting activity of conditioned medium on spinal cord explants.
L. B. Dribin (1982)
REVERSAL OF AXONAL TRANSPORT AT A NERVE CRUSH 1
M. Bisby (1977)
Selective retrograde labeling indicating the transmitter of neuronal pathways
P. Streit (1980)
Reversed polarity of rapid axonal transport in chicken motoneurons.
J. Bray (1971)
Ascending Monoamine Neurons to the Telencephalon and Diencephalon
N. Andén (1966)
Axonal transport of beta-adrenergic receptors. Antero- and retrogradely transported receptors differ in agonist affinity and nucleotide sensitivity.
M. Zarbin (1983)
Role of degenerating axon pathways in regeneration of mouse soleus motor axons.
M. C. Brown (1981)
Rapid and precise down regulation of fast axonal transport of transmitter in an identified neuron.
J. Aletta (1982)
The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles
S. Tsukita (1980)
Factors involved in the control of RNA synthesis during regeneration of the optic nerve in the frog
T. Scott (1982)
Membrane conductance and action potential of a regenerating axonal tip.
H. Meiri (1981)
Axotomy Mimicked by Localized Colchicine Application
G. Pilar (1972)
Nerve regeneration in silicone chambers: Influence of gap length and of distal stump components
G. Lundborg (1982)
Nerve growth factor stimulates neurite outgrowth from goldfish retinal explants: the influence of a prior lesion.
J. Turner (1982)
Binding, internalization, and retrograde transport of 125I-nerve growth factor in cultured rat sympathetic neurons
P. Claude (1982)
Velocity of labeled protein undergoing anterograde and retrograde axonal transport
M. Bisby (1981)
The metabolic background for peripheral nerve surgery.
T. Ducker (1969)
Axonal growth during regeneration: a quantitative autoradiographic study
A. Tessler (1980)
A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat
M. R. Matthews (1972)
Differences in incorporation of axonally transported protein in regenerating motor and sensory axons
M. Bisby (1979)
Reversal of Axonal Transport: Similarity of Proteins Transported in Anterograde and Retrograde Directions
M. Bisby (1981)
Extracts of skeletal muscle increase neurite outgrowth and cholinergic activity of fetal rat spinal motor neurons.
R. Smith (1983)
The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea‐pig.
A. Njå (1978)
The effects of postganglionic axotomy and nerve growth factor on the superior cervical ganglia of developing mice
B. Banks (1977)
Smooth Endoplasmic Reticulum and Axonal Transport
A. Rambourg (1980)
Lesion-Induced Neuronal Plasticity in Sensorimotor Systems
H. Flohr (1981)
Modification of a rapidly transported protein in regenerating nerve
B. Tedeschi (1983)
Effect of a Conditioning Lesion on Axonal Regeneration and Recovery of Function
D. Forman (1981)
Axoplasmic transport and possible recycling of opiate receptors labelled with 3H-lofentanil.
P. Laduron (1982)
Axon-myelin transfer of phosphilipid components in the course of their axonal transport as visualized by radioautography
B. Droz (1978)
Retrograde axoplasmic transport of inactive dopamine-β-hydroxylase in sciatic nerves
I. Nagatsu (1976)
Relation of somal lipid synthesis to the fast axonal transport of protein and lipid
F. Longo (1980)
Ionic requirements for in vitro retrograde axonal transport of acetylcholinesterase
P. A. Lavoie (1982)
Axonal transport of the cytoskeleton in regenerating motor neurons: constancy and change
P. Hoffman (1980)
Local control of neurite development by nerve growth factor.
R. Campenot (1977)
Some responses of neurones of dorsal root ganglia to axotomy.
Watson We (1973)
Properties of fast and slow alpha motoneurones following motor reinnervation
M. Kuno (1974)
AXONAL TRANSPORT OF SELECTED PARTICLE‐SPECIFIC ENZYMES IN RAT SCIATIC NERVE IN VIVO AND ITS RESPONSE TO INJURY
R. Schmidt (1978)
Tropism in nerve regeneration in vivo. Attraction of regenerating axons by diffusible factors derived from cells in distal nerve stumps of transected peripheral nerves
M. Politis (1982)
The short term accumulation of axonally transported organelles in the region of localized lesions of single myelinated axons
R. S. Smith (1980)
REVERSAL OF AXONAL TRANSPORT IN REGENERATING NERVES 1
V. T. Bulger (1978)
Functional and structural changes in mammalian sympathetic neurones following interruption of their axons.
D. Purves (1975)
Axoplasmic transport of muscarinic receptors
P. Laduron (1980)
Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve
W. Schlaepfer (1979)
Rapid transport of phosphatidylcholine occurring simultaneously with protein transport in the frog sciatic nerve.
T. Abe (1973)
The intra-axonal transport of acetylcholine and cholinergic enzymes in rat sciatic nerve during regeneration after various types of axonal trauma.
P. Heiwall (1979)
Axonal transport of acetylcholine, choline acetyltransferase and cholinesterase in regenerating peripheral nerve.
R. O'brien (1978)
Evidence for the maintenance of motoneurone properties by msucel activity.
G. Czéh (1978)
Lectin labeling of sprouting neurons. III. Type-specific glycoconjugates on growth cones of different origin.
K. Pfenninger (1984)
Studies in developmental neurobiology : essays in honor of Viktor Hamburger
V. Hamburger (1981)
Reversible changes in the accumulation and activities of tyrosine hydroxylase and dopamine-β-hydroxylase in neurons of nucleus locus coeruleus during the retrograde reaction
R. Ross (1975)
Dependence of motoneurone properties on the length of immobilized muscle
R. Gallego (1979)
Retrograde axoplasmic transport: Its continuation as anterograde transport
T. Abe (1974)
Properties of a calcium-activated protease in squid axoplasm which selectively degrades neurofilament proteins.
H. Pant (1980)
Axonal transport of muscarinic cholinergic receptors in rat vagus nerve: high and low affinity agonist receptors move in opposite directions and differ in nucleotide sensitivity
M. Zarbin (1982)
Changes in the amounts of cytoskeletal proteins within the perikarya and axons of regenerating frog motoneurons
D. Sinicropi (1983)
Regeneration of motor axons in the rat sciatic nerve studied by labeling with axonally transported radioactive proteins
D. Forman (1978)
Dynamic changes in brain dopamine-beta-hydroxylase activity during anterograde and retrograde reactions to injury of central noradrenergic axons.
D. Reis (1973)
Quantitative ultrastructural observations on the inhibited recovery of the hypoglossal nucleus from the axotomy response when regeneration of the hypoglossal nerve is prevented
B. Sumner (2004)
Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor
V. Hamburger (1981)
Prolonged alteration in composition of fast transported protein in axons prevented from regenerating after injury.
M. Bisby (1982)
Lectin labeling of sprouting neurons. II. Relative movement and appearance of glycoconjugates during plasmalemmal expansion
K. Pfenninger (1981)
Recovery of Axonal Transport of Acetylcholinesterase in Regenerating Sciatic Nerve Precedes Muscle Reinnervation
L. Giamberardino (1982)
Conditioned medium increases the rate of neurite elongation: separation of this activity from the substratum-bound inducer of neurite outgrowth
F. Collins (1982)
Cytoplasmic transport: moving ultrastructural elements common to many cell types revealed by video-enhanced microscopy.
R. Allen (1982)
Ca2+ and Calmodulin‐Dependent Phosphorylation of Endogenous Synaptic Vesicle Tubulin by a Vesicle‐Bound Calmodulin Kinase System
B. Burke (1982)
Essays on the nervous system: Edited by R. Bellairs and E.G. Gray, Clarendon Press, Oxford, 1974. 511 pp. £11.50
H. Hécaen (1975)
The response of adrenergic neurones to axotomy and nerve growth factor
I. Hendry (1975)
Regeneration of neurites on long-term cultures of sympathetic neurons deprived of nerve growth factor.
R. Campenot (1981)
Axonal transport of lectins in the peripheral nervous system
L. Borges (1982)
TRANSPORT, TURNOVER AND DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE AND ACETYLCHOLIN‐ESTERASE IN THE VAGUS AND HYPOGLOSSAL NERVES OF THE RABBIT
F. Fonnum (1973)
Effects of aging on nerve sprouting and regeneration
A. Pestronk (1980)
Turnaround of Axoplasmic Transport of Selected Particle‐Specific Enzymes at an Injury in Control and Diisopropylphosphorofluoridate‐Treated Rats
Robert E. Schmidt (1980)
Studies on the localization of newly added membrane in growing neurites.
E. Feldman (1981)
Axonal regeneration in the rat sciatic nerve: Effect of a conditioning lesion and of dbcAMP
I. Mcquarrie (1977)
Changes in the composition of labeled protein transported in motor axons during their regeneration.
M. Bisby (1980)
ACTH accelerates recovery of neuromuscular function following crushing of peripheral nerve
F. Strand (1980)
Effect of repeated hypoglossal nerve lesions on the number of neurons in the hypoglossal nucleus of adult rats
J. Arvidsson (1982)
How does tetanus toxin act?
J. Mellanby (1981)
TRANSPORT OF PROTEINS, GLYCOPROTEINS AND CHOLINERGIC ENZYMES IN REGENERATING HYPOGLOSSAL NEURONS 1
M. Frizell (1974)
A study of the motion of organelles which undergo retrograde and anterograde rapid axonal transport in Xenopus
Z. Koles (1982)
Increased regeneration rate in peripheral nerve axons following double lesions: enhancement of the conditioning lesion phenomenon.
M. Bisby (1983)
The axoplasmic reticulum within myelinated axons is not transported rapidly
M. Ellisman (1983)
Protein synthesis and axonal transport in goldfish retinal ganglion cells during regeneration accelerated by a conditioning lesion
I. Mcquarrie (1982)
Axonal transport of phospholipid in goldfish optic system
B. Grafstein (1975)
Retention and redistribution of proteins in mammalian nerve fibres by axoplasmic transport.
S. Ochs (1975)
Axoplasmic Transport in Physiology and Pathology
D. Weiss (1982)
Target tissue control of nerve fiber growth rate and periodicity in vitro.
W. L. Muhlach (1982)
Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium
R. Nixon (1983)
Factor(s) from goldfish brain induce neuritic outgrowth from explanted regenerating retinas.
M. Schwartz (1982)
Slowing of the rate of axonal regeneration during growth and maturation
M. Black (1979)
A quantitative analysis of isotope concentration profiles and rapid transport velocities in the C-fibers of the garfish olfactory nerve.
G. Gross (1975)
Incorporation of axonally transported glycoproteins into axolemma during nerve regeneration
J. Griffin (1981)
A blind controlled trial of adrenocorticotropin and cerebral gangliosides in nerve regeneration in the rat
J. P. Verghese (1982)
Mg2+‐ or Ca2+‐Activated ATPase in Squid Giant Fiber Axoplasm
G. Shecket (1982)
Fast axonal transport of labeled protein in sensory axons during regeneration
M. Bisby (1978)
Blockade of retrograde axonal transport delays the onset of metabolic and morphologic changes induced by axotomy
P. Singer (1982)
‘Acrylamide-induced’ neuropathy and impairment of axonal transport of proteins. I. Multifocal retention of fast transported proteins at the periphery of axons as revealed by light microscope radioautography
F. Souyri (1981)
Axonal transport: a quantitative study of retained and transported protein fraction in the cat.
E. J. Muñoz-Martínez (1981)
Ultrastructural data, with special reference to bouton/glial relationships, from the hypoglossal nucleus after a second axotomy of the hypoglossal nerve
B. Sumner (2004)
Responses in the hypoglossal nucleus to delayed regeneration of the transected hypoglossal nerve, a quantitative ultrastructural study
B. Sumner (2004)
This paper is referenced by
Morphometric and ultrastructural studies of the sciatic nerve regeneration in rats intoxicated with ethanol.
L. Zimnoch (2000)
The growth-associated protein gap-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury
C. Woolf (1990)
Morphologic changes in nerve cell bodies induced by experimental graded nerve compression
L. Dahlin (1987)
THE RETINA AS A REGENERATING ORGAN
B. Grafstein (1986)
Injury and repair of the musculoskeletal soft tissues. Savannah, Georgia, June 18–20, 1987
S. Woo (1988)
Effect of laser radiation on post-traumatic restoration of interneuronal connections of the sympathetic trunk
A. R. Rakhishev (2005)
Progressive Deficit of Retrograde Axonal Transport Is Associated with the Pathogenesis of Di‐n‐Butyl Dichlorvos Axonopathy
A. Moretto (1987)
Calcium dependent modulation of fast axonal transport.
A. Breuer (1988)
Response of rubrospinal and corticospinal neurons to injury and neurotrophins.
W. Tetzlaff (1994)
Regeneration of neurosecretory axons into various types of intrahypothalamic graft is promoted by the absence of the blood‐brain barrier: A neurophysin‐immunohistochemical and horseradish peroxidase‐histochemical study
M. Ouassat (1997)
Chapter 4 Receptor mediated retrograde axonal transport of neurotrophic factors is increased after peripheral nerve injury
P. Distefano (1994)
Magnocellular neurosecretory axon regeneration into rat intrahypothalamic optic nerve allografts
H. Dellmann (1989)
Axotomy-induced ornithine decarboxylase activity in the mouse dorsal root ganglion is inhibited by the vinca alkaloids
A. Soiefer (2004)
The neurone and its response to peripheral nerve compression.
L. Dahlin (1990)
Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43
W. Tetzlaff (1991)
Neuronal Injury Increases Retrograde Axonal Transport of the Neurotrophins to Spinal Sensory Neurons and Motor Neurons via Multiple Receptor Mechanisms
R. Curtis (1998)
Graded inhibition of retrograde axonal transport by compression of rabbit vagus nerve
L. Dahlin (1986)
Development and Regeneration of the Nervous System
S. Nona (1992)
Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve
R. Curtis (1994)
Intracellular transport using microtubule-based motors.
R. Vale (1987)
On retrograde signalling and molecular events associated with nerve damage and regeneration
G. W. Perry (1992)
Effects of intraneural injection of taxol on retrograde axonal transport and morphology of corresponding nerve cell bodies
I. Nennesmo (1988)
Molecular and cellular aspects of nerve regeneration.
M. Schwartz (1987)
Mechanisms at the axon tip regulate metabolic processes critical to axonal elongation.
R. Lasek (1987)
Fast axonally transported proteins in regenerating goldfish optic axons
G. Perry (1987)
Influence of temperature on various mechanisms associated with neuronal growth and nerve regeneration
P. Cancalon (1985)
Fast axonal transport: recent developments.
D. Forman (1987)
Characterization of retrograde axonal transport of antibodies in central and peripheral neurons.
R. Wenthold (1986)
mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration
R. Takemura (1996)
Regeneration of neurosecretory axons into intrahypothalamic grafts of neural lobe, sciatic nerve, and optic nerve: a neurophysin-immunohistochemical, HRP-histochemical, and fine structural study
M. Ouassat (1992)