Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Extensive Alteration Of Genomic DNA And Rise In Nuclear Ca2+ In Vivo Early After Hepatotoxic Acetaminophen Overdose In Mice.

S. Ray, C. L. Sorge, A. Tavacoli, J. Raucy, G. Corcoran
Published 1991 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Hepatotoxic doses of acetaminophen cause early impairment of Ca2+ homeostasis. In this in vivo study, 600 mg/kg acetaminophen caused total nuclear Ca2+ and % fragmented DNA to rise in parallel from 2-6 hr, followed by large later increases mirroring frank liver injury. Agarose gel electrophoresis revealed substantial loss of large genomic DNA from 2 hours onward, with accumulation of DNA fragments in a ladder-like pattern resembling apoptosis. Extensive late cleavage of DNA probably resulted from cell death, whereas degradative loss of large genomic DNA at 2 hours arose at an early enough point to contribute to acetaminophen-induced liver necrosis in mice.
This paper references
10.1126/SCIENCE.7112127
Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.
S. A. Jewell (1982)
10.1016/b978-0-12-547150-3.50015-3
A Laboratory manual
M. Ashburner (1989)
10.1126/SCIENCE.386513
Calcium dependence of toxic cell death: a final common pathway.
F. A. Schanne (1979)
10.1096/fasebj.3.7.2497041
Calcium‐activated DNA fragmentation kills immature thymocytes
D. McConkey (1989)
10.1016/0041-008X(89)90339-6
Halocarbon hepatotoxicity is not initiated by Ca2+-stimulated endonuclease activation.
R. Long (1989)
10.1016/0014-4827(56)90107-0
Isolation of pure and unaltered liver nuclei morphology and biochemical composition.
J. Chauveau (1956)
Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.
J. Cohen (1984)
10.1016/0003-2697(67)90273-4
A new method for determining micro quantities of calcium in biological materials.
B. C. Sarkar (1967)
10.1038/284555A0
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
A. Wyllie (1980)
10.1016/s0021-9258(18)83363-4
Calcium-activated DNA fragmentation in rat liver nuclei.
D. P. Jones (1989)
10.1016/0009-8981(73)90101-0
Direct microdetermination of serum calcium.
E. Baginski (1973)
10.1016/0378-4274(88)90069-0
Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress.
D. McConkey (1988)
10.1016/s0021-9258(17)38834-8
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
M. Moore (1985)
10.1042/BJ0620315
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.
Kenneth Burton (1956)
10.1016/0167-5699(86)90152-0
Death and the cell.
E. Duvall (1986)
10.1016/0006-2952(80)90356-1
Inhibition of liver-microsome calcium pump by in vivo administration of CCl4, CHCl3 and 1,1-dichloroethylene (vinylidene chloride).
L. Moore (1980)
10.3181/00379727-91-22330
Serum Glutamic Pyruvic Transaminase in Cardiac and Hepatic Disease.∗
F. Wróblewski (1956)
Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction.
K. Chien (1979)
10.1016/0006-291X(73)90736-5
The calcium dependent endonuclease activity of isolated nuclear preparations. Relationships between its occurrence and the occurrence of other classes of enzymes found in nuclear preparations.
D. Hewish (1973)
10.1016/s0021-9258(18)33615-9
Endogenous nuclease. Properties and effects on transcribed genes in chromatin.
J. Vanderbilt (1982)
10.1126/SCIENCE.3262923
2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
D. McConkey (1988)
Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice.
G. Corcoran (1987)
10.1016/s0021-9258(18)66917-0
Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.
P. Nicotera (1986)
10.1016/0300-483X(88)90088-1
Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice.
G. Corcoran (1988)
10.1126/SCIENCE.3103219
Regional changes in calcium underlying contraction of single smooth muscle cells.
D. Williams (1987)



This paper is referenced by
10.1210/EDRV-14-2-133
Apoptosis: the biochemistry and molecular biology of programmed cell death.
R. A. Schwartzman (1993)
10.1002/jgm.194
EC‐SOD gene therapy reduces paracetamol‐induced liver damage in mice
M. Laukkanen (2001)
10.1016/S1089-3261(05)70112-4
Apoptosis in hepatic pathophysiology.
T. Patel (2000)
10.1034/J.1600-0773.2002.900108.X
Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes.
A. Boulares (2002)
10.1016/0300-483X(96)03309-4
Acetaminophen-arylated proteins are detected in hepatic subcellular fractions and numerous extra-hepatic tissues in CD-1 and C57B1/6J mice.
S. Bulera (1996)
10.1007/s001090050137
Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1
A. Hołownia (1997)
10.1097/01.ASN.0000111289.91206.B0
Paracetamol-induced renal tubular injury: a role for ER stress.
C. Lorz (2004)
10.1210/ENDO.133.2.8393769
Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids.
R. A. Schwartzman (1993)
10.1111/J.1742-7843.2004.PTO_940105.X
Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3.
A. Boulares (2004)
10.1007/s10787-998-0030-4
The role of calcium in paracetamol (acetaminophen) cytotoxicity in PC12 cells transfected with CYP4502E1
A. Hołownia (1998)
10.1016/0041-008X(92)90112-6
The role of the nucleus and other compartments in toxic cell death produced by alkylating hepatotoxicants.
G. Corcoran (1992)
10.1080/03602532.2020.1832112
The development and hepatotoxicity of acetaminophen: reviewing over a century of progress
M. McGill (2020)
10.1007/s002040050013
A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-XL, and BCL-XS during apoptotic and necrotic death of mouse liver cells in vivo
S. Ray (2000)
Biochemical studies on the protective effect of Taurine on experimentally induced Fulminat Hepatic failure in rats
K. Asha.K. (2010)
10.5897/AJPP11.855
Hepatoprotective effects of antioxidants against non- target toxicity of the bio-insecticide spinosad in rats
A. Aboul-Enein (2012)
Toxicophores: groups and metabolic routes associated with increased safety risk.
D. Williams (2002)
10.1016/S0891-5849(01)00562-7
Ca(2+)-calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of BCL-XL and P53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice.
S. Ray (2001)
10.1002/9780470744307.GAT015
Cell Death and Apoptosis
S. Ray (2009)
10.1007/s00580-003-0475-1
Adverse drug reactions, transcription factors and transcriptomics
D. Williams (2003)
The role of TRPM2 channels in oxidative stress-induced liver damage.
K. Ehsan (2015)
10.1179/135100005X38879
Cytoprotective effects of carvedilol against oxygen free radical generation in rat liver
G. E. Ronsein (2005)
Apoptosis Related Protein Bax In Liver Of Metalaxyl Fungicide -Treated Mice: The Effect Of Antox
S. Sakr (2008)
10.1016/0098-2997(95)00006-2
Apoptosis--molecular mechanisms and biomedical implications.
D. McConkey (1996)
10.1080/20014091111677
Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches
J. Bessems (2001)
10.1002/HEP.510230641
The translational inhibitor cycloheximide represses growth factor depletion‐induced apoptosis in an alb‐SV40T transgenic rat liver cell line
S. Bulera (1996)
10.1016/S0891-5849(01)00560-3
Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death.
E. J. Hickey (2001)
Semantic Scholar Logo Some data provided by SemanticScholar