Online citations, reference lists, and bibliographies.

Sympathetic Innervation And Blood Flow In The Diabetec Heart

O. Schnell
Published 2002 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The balance of the activity of the cardiac sympathetic and parasympathetic nervous system plays a key role for the functional and structural performance of the diabetic heart.1 Metabolic, vascular/hemorrheological and, in type 1 diabetes mellitus, immunological factors are currently hypothezised to contribute to the pathogenesis, which, however, has not been fully elucidated.1 The heterogeneous pattern and the high extent of dysfunction of the cardiac sympathetic nervous system in diabetes mellitus had remained largely unknown until advanced scintigraphic techniques for direct characterization of dysfunction of sympathetic neurons in the living heart emerged in the 1990’s. Previously, diagnosis of cardiac sympathetic abnormalities had been mainly based on conventional non-invasive cardiac reflex tests, including measurements of heart rate variation and blood pressure changes to standing. These tests, however, only indirectly assess diabetic cardiac autonomic dysfunction, they do not differentiate absolutely between sympathetic and parasympathetic function and they do not assess the heart regionally. Imbalance of the activity of the cardiac sympathetic nervous system is suggested to lead to multiple functional disturbances and to increase the risk for arrythmogenicity of the diabetic heart.2
This paper references
10.1055/S-0029-1212117
Scintigraphically assessed cardiac sympathetic dysinnervation in poorly controlled type 1 diabetes mellitus: one-year follow-up with improved metabolic control.
D. Muhr-Becker (1999)
10.1007/BF00403917
Autoantibodies against sympathetic ganglia and evidence of cardiac sympathetic dysinnervation in newly diagnosed and long-term IDDM patients
O. Schnell (1996)
10.1016/0735-1097(94)00459-4
Metaiodobenzylguanidine imaging in diabetes mellitus: assessment of cardiac sympathetic denervation and its relation to autonomic dysfunction and silent myocardial ischemia.
A. Langer (1995)
10.1161/01.CIR.100.8.813
Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus.
M. D. Di Carli (1999)
10.1007/BF00401768
Scintigraphic evidence for cardiac sympathetic dysinnervation in long-term IDDM patients with and without ECG-based autonomic neuropathy
O. Schnell (1995)
10.1161/01.CIR.94.1.44
Regulation of nitric oxide production in human coronary microvessels and the contribution of local kinin formation.
M. Kichuk (1996)
10.1016/S1056-8727(97)00015-9
Three-year follow-up on scintigraphically assessed cardiac sympathetic denervation in patients with long-term insulin-dependent (type I) diabetes mellitus.
O. Schnell (1997)
10.2337/diab.41.9.1069
Noninvasive Detection of Cardiac Sympathetic Nervous Dysfunction in Diabetic Patients Using [123I]Metaiodobenzylguanidine
M. Mäntysaari (1992)
10.2337/diacare.20.6.1009
Autoantibodies to Sympathetic Ganglia, GAD, or Tyrosine Phosphatase in Long-Term IDDM With and Without ECG-Based Cardiac Autonomic Neuropathy
D. Muhr (1997)
10.2337/diab.44.12.1355
Clinical Trials of Diabetic Neuropathy: Past, Present, and Future
M. Pfeifer (1995)
10.1007/s001250051556
A new look at the heart in diabetes mellitus: from ailing to failing
E. Standl (2000)
10.1002/(SICI)1096-9136(199701)14:1<57::AID-DIA297>3.0.CO;2-7
Partial restoration of scintigraphically assessed cardiac sympathetic denervation in newly diagnosed patients with insulin-dependent (type 1) diabetes mellitus at one-year follow-up.
O. Schnell (1997)
10.1016/0735-1097(93)90553-D
Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography.
K. Allman (1993)
10.1016/0735-1097(89)90414-2
Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium.
A. Zeiher (1989)
10.1161/01.CIR.98.10.961
Cardiac sympathetic dysinnervation in diabetes: implications for enhanced cardiovascular risk.
M. Stevens (1998)
Perspectives in Diabetes Clinical Trials of Diabetic Neuropathy: Past, Present, and Future
M. Pfeifer (1995)
10.2337/diab.45.6.801
Reduced Myocardial 123I-Metaiodobenzylguanidine Uptake in Newly Diagnosed IDDM Patients
O. Schnell (1996)
10.1055/S-2000-7741
Autoantibodies against autonomic nervous tissues in type 2 diabetes mellitus: no association with cardiac autonomic dysfunction.
O. Schnell (2000)
10.1016/S0140-6736(99)06057-2
Cardiological applications of nuclear medicine
M. Schwaiger (1999)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar