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Nanoparticles And Liposomes In Ophthalmic Drug Delivery

J. Kreuter
Published 1987 · Chemistry

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The drainage and ocular distribution of nanoparticles and liposomes was investigated ysing the labelling of the nanoparticle polymer with 14C and the binding of a tracer, 111In-oxine, on to the particles and to the liposomes. The longest precorneal half-life was observed with positively charged liposomes yielding an about 3-fold increase in comparison to a simple solution. The half-life in the inner canthus was prolonged from 5 min to about 20 min. In the inner canthus, nanoparticles had the longest half-life. About 1 % of the initial nanoparticle dose adhered to the corneal and conjunctival surfaces for over 6 hours. While a lower ophthalmic absorption of the lipophilic drug progesterone was observed, a 1.4-fold higher efficacy of the more hydrophilic drug pilocarpine was obtained after binding to nanoparticles as determined by miosis measurements.
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