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Pharmacokinetics And Biopharmaceutical Aspects Of Some Anti-Glaucoma Drugs

B. Plazonnet, J. Grove, M. Durr, Claude Mazuel, M. Quint, A. Rozier
Published 1987 · Medicine

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The therapy of glaucoma has used several classes of active ingredients which were mostly cholinergic and adrenergic drugs. The carbonic anhydrase inhibitors were essentially systemic drugs but recently new potent compounds have been described to be active after topical administration. Each class of drugs has a different pharmacokinetic behaviour due to the physico-chemical properties of the individual compounds. The dynamics of ocular fluids, especially the turnover of tears, are responsible for a poor availability of drugs administered topically in the conjunctival cul-de-sac. The recent galenic developments in ophthalmic formulations have essentially aimed at achieving better control of the residence of anti-glaucoma drugs close to the anterior segment of the eye and derivatization and prodrug approaches have improved transcorneal penetration.
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