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Incorporating Assessments Of Sequence-Dependence In Developmental Studies Of Combination Chemotherapy Regimens Containing New Agents And Platinum Compounds
Published 1996 · Medicine
The evaluation of combination chemotherapy regimens that incorporate new drugs has been accepted as the next rationale step in the development of new cytotoxic agents following the completion of phase I and early phase II trials. Before incorporating new agents into combination chemotherapy regimens, the new agent should have demonstrated a sufficient level of antitumor activity in relevant tumor types. In addition, adequate preclinical and clinical information about optimal scheduling should be available. New cytotoxic agents are often combined with platinum compounds, such as cisplatin and carboplatin, if the new agents possess relevant antitumor activity in ovarian, non-small and small cell lung, bladder, and germ cell carcinomas, as well as in other malignancies in which the platinum compounds are the mainstay of therapy.