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Leucine-Protein Supplemented Recovery And Exercise

Andre Nelson, Leonidas G Karagounis, David Stephen Rowlands
Published 2015 · Biology

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The endurance-trained state is arguably the natural expression condition of human skeletal muscle [1]. Early humans experienced environmental selection pressure and migration out of Africa, that would have favoured a high physical endurance capacity [2, 3]. Improved endurance capabilities in early humans likely facilitated scavenging and persistence hunting and the co-emergence and increased post-exercise consumption of readily digestible protein and calorie intake [4]. Therefore, scavenging, hunting and gathering a high-protein diet [5] coupled with long-durations of endurance exercise (up to 8 h) supported not only the high energetic and tissue amino acid requirements of the musculoskeletal system, but also the metabolic demands of an increasingly larger brain mass contributing to social, cultural and technological development [5]. Animals would have been consumed within the hours following hunting, tracking or gathering, which is also when nutrient delivery to the exercised tissue is best because of transient increases in muscle blood flow, insulin sensitivity and glucose and amino acid uptake [6, 7]. Disturbances to muscle homeostasis from regular endurance exercise coupled with post-exercise hyperaminoacidaemia from a protein-rich diet might, therefore, be the normal environmental cues for adaptive remodelling in human skeletal muscle [8].
This paper references
Determinants of Post-Exercise Glycogen Synthesis During Short-Term Recovery
R. Jentjens (2003)
The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis.
L. Breen (2011)
Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men.
D. Moore (2009)
Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies
N. Zanchi (2008)
Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis.
S. Pasiakos (2011)
Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men.
T. A. Churchward-Venne (2012)
Protein-leucine fed dose effects on muscle protein synthesis after endurance exercise.
D. Rowlands (2015)
Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis.
S. Kimball (2006)
Global relationship between the proteome and transcriptome of human skeletal muscle.
Z. Yi (2008)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Q. Sun (2011)
Acute effects of chocolate milk and a commercial recovery beverage on postexercise recovery indices and endurance cycling performance.
Kelly M. Pritchett (2009)
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
J. T. Cunningham (2007)
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice.
G. D’Antona (2010)
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
K. Düvel (2010)
Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.
M. Drummond (2011)
Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
C. Stump (2003)
Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement.
R. Barazzoni (2012)
A bovine whey protein extract stimulates human neutrophils to generate bioactive IL-1Ra through a NF-kappaB- and MAPK-dependent mechanism.
D. Rusu (2010)
Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases
C. Mayer (2006)
Impact of protein and carbohydrate supplementation on plasma volume expansion and thermoregulatory adaptation by aerobic training in older men.
K. Okazaki (2009)
Postexercise whole-body protein turnover response to three levels of protein intake.
P. C. Gaine (2007)
Aerobic Exercise Training Adaptations Are Increased by Postexercise Carbohydrate-Protein Supplementation
Lisa Ferguson-Stegall (2011)
Protein-Leucine Fed Dose Effects on Muscle Protein Synthesis after Endurance Exercise: 382 Board #220 May 28, 11
David Stephen Rowlands (2014)
Long‐term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are not altered by protein supplementation
M. Robinson (2011)
Physical exercise as an evolutionary force
W. Bortz (1985)
Role of matrix metalloproteinases in skeletal muscle
X. Chen (2009)
Waging war on modern chronic diseases: primary prevention through exercise biology.
F. Booth (2000)
Glycemic Index and Glycemic Load and Their Association with C-Reactive Protein and Incident Type 2 Diabetes
G. J. van Woudenbergh (2011)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
P. Nicklin (2009)
Effect of post-exercise protein–leucine feeding on neutrophil function, immunomodulatory plasma metabolites and cortisol during a 6-day block of intense cycling
A. Nelson (2013)
Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.
S. Verhoeven (2009)
Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells
P. Atherton (2009)
Proline and hydroxyproline metabolism: implications for animal and human nutrition
G. Wu (2010)
Chocolate milk and endurance exercise recovery: protein balance, glycogen, and performance.
William R. Lunn (2012)
A protein-leucine supplement increases BCAA and nitrogen turnover but not performance
AR Nelson (2012)
Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp.
S. Rome (2003)
Structural rearrangements in contractile apparatus and resulting skeletal muscle remodelling: effect of exercise training.
T. Seene (2009)
Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases.
I. Baptista (2010)
TOR Signaling in Growth and Metabolism
Stephan Wullschleger (2006)
Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle
P. Greenhaff (2008)
Effect of protein-rich feeding on recovery after intense exercise.
D. Rowlands (2007)
Aberrant repair and fibrosis development in skeletal muscle
C. J. Mann (2011)
Our ancestral physiological phenotype: an adaptation for hypoxia tolerance and for endurance performance?
P. Hochachka (1998)
How human neutrophils kill and degrade microbes: an integrated view
W. Nauseef (2007)
Macrophages in Injured Skeletal Muscle: A Perpetuum Mobile Causing and Limiting Fibrosis, Prompting or Restricting Resolution and Regeneration
L. Bosurgi (2011)
Maximizing postexercise muscle glycogen synthesis: carbohydrate supplementation and the application of amino acid or protein hydrolysate mixtures.
L. V. van Loon (2000)
2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training.
B. Egan (2011)
Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels.
A. Haegens (2012)
Effect of dietary protein content during recovery from high-intensity cycling on subsequent performance and markers of stress, inflammation, and muscle damage in well-trained men.
D. Rowlands (2008)
Regulation of Gene Expression in Hepatic Cells by the Mammalian Target of Rapamycin (mTOR)
R. H. Jiménez (2010)
Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study.
J. Bohé (2003)
Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein.
D. Rowlands (2011)
Leucine-protein supplemented recovery feeding enhances subsequent cycling performance in well-trained men.
Jasmine S. Thomson (2011)
Regulatory interactions between muscle and the immune system during muscle regeneration.
J. Tidball (2010)
Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise.
D. R. Bolster (2005)
The different relationship of VO2max to muscle mitochondria in humans and quadrupedal animals.
H. Hoppeler (1990)
Insulin Stimulates Human Skeletal Muscle Protein Synthesis via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and Mammalian Target of Rapamycin Complex 1 Signaling.
K. L. Timmerman (2010)
Out of Africa and into an ice age: on the role of global climate change in the late Pleistocene migration of early modern humans out of Africa.
S. Carto (2009)
Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
D. J. Mahoney (2005)
Making room for protein in approaches to muscle recovery from endurance exercise.
N. R. Rodríguez (2009)
Skeletal muscle responses to negative energy balance: effects of dietary protein.
J. W. Carbone (2012)
Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in Type 2 diabetic men.
R. Manders (2006)
Microarray Profiling of Human Skeletal Muscle Reveals That Insulin Regulates ∼800 Genes during a Hyperinsulinemic Clamp* 210
S. Rome (2003)
Coingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humans.
Krista R. Howarth (2009)
Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle.
S. Wilkinson (2008)
Nutritional strategies to promote postexercise recovery.
M. Beelen (2010)
Postexercise carbohydrate-protein- antioxidant ingestion decreases plasma creatine kinase and muscle soreness.
N. Luden (2007)
A protein-leucine supplement increases branched-chain amino acid and nitrogen turnover but not performance.
A. Nelson (2012)
Current understanding of increased insulin sensitivity after exercise – emerging candidates
S. Maarbjerg (2011)
Muscle protein synthesis and gene expression during recovery from aerobic exercise in the fasted and fed states.
M. Harber (2010)

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