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IGFs And Skeletal Muscle

S. Rosenthal
Published 1999 · Biology

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The insulin-like growth factors (IGFs) are unique in that they are the only known mitogens that, when free of other serum components, stimulate both the proliferation and differentiation of skeletal muscle cells. This dual effect of IGFs is of particular interest because these two processes are believed to be mutually exclusive in this tissue and in a wide variety of cell types (1). Thus, exploring this model of IGF action in skeletal muscle provides an opportunity to address a fundamental issue in cell biology: understanding the mechanisms that influence the decision of a particular cell type to proliferate or differentiate. The focus of this chapter is on the interface of IGF biology with that of skeletal muscle embryogenesis/differentiation and cell cycle regulation, with particular emphasis on exploring the mechanisms by which IGFs influence the decision of skeletal muscle cells to proliferate or differentiate.
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