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Drug–Nutrient Interactions In The Elderly

B. Kinosian, Tanya C. Knight-Klimas
Published 2009 · Medicine

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The elderly are more prone to experience drug-nutrient interactions (DNIs) given their higher use of medication, chronic and cumulative disorders, and the likelihood of marginal nutritional state. The elderly, arbitrarily defined as those 65 yr of age and older, constitute approx 14% of the US population. By the year 2030, the elderly cohort will grow to approx 20% of the nation’s population, with the “old-old” cohort, aged 85 yr and older, being the most rapidly growing segment of the population (1). Elder adults are the most heterogeneous population with respect to physical, social, and health status (2). The rate at which an individual ages is variable, and how well an individual ages is also variable, being dependent on both genetic and environmental factors (2). For instance, one 75-yr-old gentleman may be viewed as being a frail elder if he is suffering from chronic disease and disability, whereas another 75-yr-old gentleman may be viewed as having aged “successfully” if he has limited disease and disability (3,4). Frailty refers to a loss of physiologic reserve that makes a person susceptible to disability from minor stresses (5). Rockwood and colleagues evaluated the many different proposed definitions of frailty by different authors and suggest that any definition that is used must include multisystem impairment, instability, change over time, an association with aging, and an associated increased risk of adverse outcome (6). Successful aging has been described as a process by which deleterious effects are minimized and function is preserved (4). Therefore, chronological age is not as descriptive as physiological age when assessing the health status of an individual.
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