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Pathogenesis Of Hypertension And Renal Disease In Obesity

T. Hunley, V. Kon
Published 2010 · Medicine

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Obesity, hypertension, and renal injury are linked by complex inter-relationships. Obesity-associated metabolic abnormalities promote both systemic hypertension and renal injury; hypertension in turn results from, and contributes to, progressive renal damage, regardless of primary cause. It is now well established that obesity dramatically increases the risks of type-II diabetes and diabetic nephropathy; yet even in the absence of diabetes, obesity predisposes to chronic kidney disease and accelerates its progression. In this chapter we discuss the pathogenesis of hypertension and renal disease in obese adults and children and reflect on their implications for therapy.
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