Models Of Mitochondrial Oxidative Stress
E. Cadenas, A. Boveris
Published 2011 · Chemistry
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Mitochondria are sources of H2O2 under aerobic and physiological conditions; the mitochondrial H2O2 generation is conceived as a consequence of the univalent and nonenzymatic reduction of oxygen to superoxide anion followed by its disproportionation to H2O2. Recognized sites for the univalent reduction of oxygen to superoxide are the autoxidation of ubisemiquinone in complex I and complex III and probably the autoxidation of the flavin semiquinone in complex I. The formation of H2O2 by mitochondria acquires further significance when considering that it reports a high mitochondrial energy charge by its diffusion to the cytosol and that it may be involved in domain-specific signaling pathways or signaling in localized subcellular areas. H2O2 is considered a major player in the redox regulation of cell signaling by modulating the activity of glutathione-, thioredoxin-, and peroxiredoxin-supported systems. Although H2O2 is highly diffusible across biological membranes, significant gradients are established in the cells and the involvement of mitochondrial H2O2 in the regulation of specific signaling pathways requires careful consideration of its sources, of its removal by specific enzymic systems, and of the mechanism by which H2O2 modifies the signaling pathways.
This paper references
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
A. Schapira (2008)
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
G. Brown (1995)
Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration
A. Boveris (1975)
Redox-based regulation of signal transduction: principles, pitfalls, and promises.
Y. Janssen-Heininger (2008)
Mitochondrial production of superoxide radical and hydrogen peroxide.
A. Boveris (1977)
Dihydroorotate-dependent superoxide production in rat brain and liver. A function of the primary dehydrogenase.
H. Forman (1976)
NOX enzymes and the biology of reactive oxygen
J. Lambeth (2004)
Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo
M. Zou (2004)
Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal
O. Y. Pletjushkina (2006)
NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation.
K. Takeshige (1979)
Use of specific inhibitors on the mitochondrial bc1 complex.
G. von Jagow (1986)
Specificity in reactive oxidant signaling: think globally, act locally
L. Terada (2006)
H2O2, a Necessary Evil for Cell Signaling
S. Rhee (2006)
Peroxidase Properties of Extracellular Superoxide Dismutase: Role of Uric Acid in Modulating In Vivo Activity
H. U. Hink (2002)
Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles.
J. Poderoso (1996)
Mitochondrial superoxide anion production and release into intermembrane space.
D. Han (2002)
Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection.
M. Naoi (2006)
The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA.
N. Hauptmann (1996)
On the biologic role of the reaction of NO with oxidized cytochrome c oxidase.
F. Antunes (2007)
c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons.
Qiongqiong Zhou (2008)
Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative stress measurements.
C. Rota (1999)
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.
J. Turrens (1980)
Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiology.
C. Cooper (2007)
Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol.
A. Boveris (2006)
Philosophical transactions of the Royal Society of London. B
Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria.
A. Boveris (1984)
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome.
C. Gómez (2007)
Purification and determination of activity of mitochondrial cyanide-sensitive superoxide dismutase in rat tissue extract.
P. Iñarrea (2002)
Brain mitochondrial dysfunction in aging.
A. Boveris (2008)
Mitochondrial complex I deficiency in Parkinson's disease.
A. Schapira (1989)
Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture.
F. Antunes (2001)
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants.
O. Cantoni (2008)
Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation
V. Yankovskaya (2003)
Inhibitors of the Quinone-binding Site Allow Rapid Superoxide Production from Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I)*
A. Lambert (2004)
Kinetics and mechanisms of catalase in peroxisomes of the mitochondrial fraction.
B. Chance (1971)
SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria.
S. Watabe (1997)
Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase.
P. Iñarrea (2005)
Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state.
A. Starkov (2003)
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
G. Brown (1994)
Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis
Robert D Guzy (2007)
Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria.
E. Cadenas (1977)
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
S. S. Korshunov (1997)
Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane*
F. Muller (2004)
Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells.
A. Bacsi (2006)
Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism
S. Nemoto (2000)
On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide.
F. Antunes (2004)
Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers.
H. Forman (2004)
How mitochondria produce reactive oxygen species
M. Murphy (2009)
Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion.
B. González-Flecha (1993)
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
A. Boveris (1973)
Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies.
A. Navarro (2009)
Activation of c‐Jun‐N‐terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging
Qiongqiong Zhou (2009)
Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III*
Y. H. Noh (2009)
Tumor Cell Phenotype Is Sustained by Selective MAPK Oxidation in Mitochondria
S. Galli (2008)
Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical.
L. Benov (1998)
Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage.
F. Schöpfer (2000)
Characteristics of α-glycerophosphate-evoked H2O2 generation in brain mitochondria
L. Tretter (2007)
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide
M. Cleeter (1994)
Thiol-based regulatory switches.
M. Paget (2003)
ADP-iron as a Fenton reactant: radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation.
J. Gutteridge (1990)
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production
P. Y. Lam (2009)
Oxidants as stimulators of signal transduction.
Y. Suzuki (1997)
Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants.
V. Skulachev (1996)
Superoxide radicals as precursors of mitochondrial hydrogen peroxide
G. Loschen (1974)
Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues.
O. Dionisi (1975)
Mitochondrial H2O2 limits U937 cell survival to peroxynitrite by promoting ERK1/2 dephosphorylation.
L. Cerioni (2008)
The cellular production of hydrogen peroxide.
A. Boveris (1972)
Myxothiazol Induces H2O2 Production from Mitochondrial Respiratory Chain
A. Starkov (2001)
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling.
S. Rhee (2005)
Regulation of JNK signaling by GSTp
V. Adler (1999)
CHAPTER 3 – Superoxide Radical and Hydrogen Peroxide in Mitochondria
H. Forman (1982)
Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis.
P. Iñarrea (2007)
Estimation of H2O2 gradients across biomembranes
F. Antunes (2000)
Respiratory chain linked H2O2 production in pigeon heart mitochondria
G. Loschen (1971)
Bridge over Troubled Waters Sensing Stress by Disulfide Bond Formation
F. Åslund (1999)
The role of H 2 O 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors.
N. Oshino (1973)
Hydroxynonenal, toxic carbonyls, and Alzheimer disease.
Q. Liu (2003)
Hydroperoxide metabolism in mammalian organs.
B. Chance (1979)
Inhibition of electron and energy transfer in mitochondria by 19-nor-ethynyltestosterone acetate.
A. Boveris (1970)
Mitochondria Are the Source of Hydrogen Peroxide for Dynamic Brain-Cell Signaling
L. Bao (2009)
Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease.
M. Carreras (2004)
Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization.
R. Weisiger (1973)
Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state.
F. Antunes (2001)
Voltage-dependent Anion Channels Control the Release of the Superoxide Anion from Mitochondria to Cytosol*
D. Han (2003)
Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase
C. Rota (1999)
Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species
A. Starkov (2004)
Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress
L. Tretter (2005)
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide.
A. Boveris (1976)
Mitochondrial H2O2 formation: Relationship with energy conservation
G. Loschen (1973)
Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria.
K. Hensley (2000)
Mitochondrial nitric oxide synthase drives redox signals for proliferation and quiescence in rat liver development
M. Carreras (2004)