Online citations, reference lists, and bibliographies.
← Back to Search

Models Of Mitochondrial Oxidative Stress

E. Cadenas, A. Boveris
Published 2011 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Mitochondria are sources of H2O2 under aerobic and physiological ­conditions; the mitochondrial H2O2 generation is conceived as a consequence of the univalent and nonenzymatic reduction of oxygen to superoxide anion followed by its disproportionation to H2O2. Recognized sites for the univalent reduction of ­oxygen to superoxide are the autoxidation of ubisemiquinone in complex I and complex III and probably the autoxidation of the flavin semiquinone in complex I. The formation of H2O2 by mitochondria acquires further significance when ­considering that it reports a high mitochondrial energy charge by its diffusion to the cytosol and that it may be involved in domain-specific signaling pathways or ­signaling in localized subcellular areas. H2O2 is considered a major player in the redox regulation of cell signaling by modulating the activity of glutathione-, ­thioredoxin-, and peroxiredoxin-supported systems. Although H2O2 is highly ­diffusible across biological membranes, significant gradients are established in the cells and the involvement of mitochondrial H2O2 in the regulation of specific signaling pathways requires careful consideration of its sources, of its removal by specific enzymic systems, and of the mechanism by which H2O2 modifies the signaling pathways.
This paper references
Philosophical transactions of the Royal Society of London. B
HighWire Press (1886)
10.1016/0003-9861(70)90184-0
Inhibition of electron and energy transfer in mitochondria by 19-nor-ethynyltestosterone acetate.
A. Boveris (1970)
10.1042/BJ1220225
Kinetics and mechanisms of catalase in peroxisomes of the mitochondrial fraction.
B. Chance (1971)
10.1016/0014-5793(71)80459-3
Respiratory chain linked H2O2 production in pigeon heart mitochondria
G. Loschen (1971)
10.1042/BJ1280617
The cellular production of hydrogen peroxide.
A. Boveris (1972)
10.1042/BJ1340707
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
A. Boveris (1973)
Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization.
R. Weisiger (1973)
10.1016/0003-9861(73)90040-4
The role of H 2 O 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors.
N. Oshino (1973)
10.1016/0014-5793(73)80165-6
Mitochondrial H2O2 formation: Relationship with energy conservation
G. Loschen (1973)
10.1016/0014-5793(74)80281-4
Superoxide radicals as precursors of mitochondrial hydrogen peroxide
G. Loschen (1974)
10.1016/0014-5793(75)80928-8
Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration
A. Boveris (1975)
10.1016/0005-2744(75)90059-5
Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues.
O. Dionisi (1975)
10.1016/0003-9861(76)90252-6
Dihydroorotate-dependent superoxide production in rat brain and liver. A function of the primary dehydrogenase.
H. Forman (1976)
10.1042/BJ1560435
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide.
A. Boveris (1976)
10.1016/0003-9861(77)90035-2
Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria.
E. Cadenas (1977)
10.1007/978-1-4615-9035-4_5
Mitochondrial production of superoxide radical and hydrogen peroxide.
A. Boveris (1977)
10.1152/PHYSREV.1979.59.3.527
Hydroperoxide metabolism in mammalian organs.
B. Chance (1979)
10.1042/BJ1800129
NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation.
K. Takeshige (1979)
10.1042/BJ1910421
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.
J. Turrens (1980)
10.1016/B978-0-12-566505-6.50010-7
CHAPTER 3 – Superoxide Radical and Hydrogen Peroxide in Mitochondria
H. Forman (1982)
10.1016/S0076-6879(84)05060-6
Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria.
A. Boveris (1984)
10.1016/S0076-6879(86)26026-7
Use of specific inhibitors on the mitochondrial bc1 complex.
G. von Jagow (1986)
10.1111/j.1471-4159.1990.tb02325.x
Mitochondrial Complex I Deficiency in Parkinson's Disease
A. H. V. Schapira (1989)
10.1016/0003-9861(90)90599-T
ADP-iron as a Fenton reactant: radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation.
J. Gutteridge (1990)
10.1172/JCI116223
Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion.
B. González-Flecha (1993)
10.1016/0014-5793(94)01290-3
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
G. Brown (1994)
10.1016/0014-5793(94)00424-2
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide
M. Cleeter (1994)
10.1016/0014-5793(95)00763-Y
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
G. Brown (1995)
10.1006/ABBI.1996.0146
Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles.
J. Poderoso (1996)
10.1017/S0033583500005795
Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants.
V. Skulachev (1996)
10.1006/ABBI.1996.0510
The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA.
N. Hauptmann (1996)
10.1111/J.1432-1033.1997.T01-1-00052.X
SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria.
S. Watabe (1997)
10.1016/S0014-5793(97)01159-9
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
S. S. Korshunov (1997)
10.1016/S0891-5849(96)00275-4
Oxidants as stimulators of signal transduction.
Y. Suzuki (1997)
10.1016/S0891-5849(98)00163-4
Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical.
L. Benov (1998)
10.1016/S0092-8674(00)80584-X
Bridge over Troubled Waters Sensing Stress by Disulfide Bond Formation
F. Åslund (1999)
10.1074/jbc.274.40.28161
Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase
Cristina Rota (1999)
10.1093/emboj/18.5.1321
Regulation of JNK signaling by GSTp
V. Adler (1999)
10.1016/S0891-5849(99)00137-9
Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative stress measurements.
C. Rota (1999)
10.1093/CARCIN/21.5.983
Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria.
K. Hensley (2000)
10.1128/MCB.20.19.7311-7318.2000
Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism
S. Nemoto (2000)
10.1042/0264-6021:3490035
Oxidation of ubiquinol by peroxynitrite: implications for protection of mitochondria against nitrosative damage.
Francisco J. Schopfer (2000)
10.1016/S0014-5793(00)01638-0
Estimation of H2O2 gradients across biomembranes
F. Antunes (2000)
10.1006/BBRC.2001.4409
Myxothiazol Induces H2O2 Production from Mitochondrial Respiratory Chain
A. Starkov (2001)
10.1016/S0891-5849(01)00493-2
Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state.
F. Antunes (2001)
10.1042/0264-6021:3560549
Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture
F. Antunes (2001)
10.1161/01.ATV.0000027524.86752.02
Peroxidase Properties of Extracellular Superoxide Dismutase: Role of Uric Acid in Modulating In Vivo Activity
H. U. Hink (2002)
10.1016/S0076-6879(02)49341-X
Mitochondrial superoxide anion production and release into intermembrane space.
D. Han (2002)
10.1016/S0076-6879(02)49326-3
Purification and determination of activity of mitochondrial cyanide-sensitive superoxide dismutase in rat tissue extract.
P. Iñarrea (2002)
10.1146/ANNUREV.GENET.37.110801.142538
Thiol-based regulatory switches.
M. Paget (2003)
10.1074/JBC.M210269200
Voltage-dependent Anion Channels Control the Release of the Superoxide Anion from Mitochondria to Cytosol*
D. Han (2003)
10.1126/SCIENCE.1079605
Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation
V. Yankovskaya (2003)
10.1046/j.1471-4159.2003.01908.x
Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state
A. Starkov (2003)
10.1016/S0098-2997(03)00025-6
Hydroxynonenal, toxic carbonyls, and Alzheimer disease.
Q. Liu (2003)
10.1002/hep.20255
Mitochondrial nitric oxide synthase drives redox signals for proliferation and quiescence in rat liver development
M. Carreras (2004)
10.1073/PNAS.0405368101
On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide.
F. Antunes (2004)
10.1152/AJPCELL.00516.2003
Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers.
H. J. Forman (2004)
10.1074/JBC.M406576200
Inhibitors of the Quinone-binding Site Allow Rapid Superoxide Production from Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I)*
A. Lambert (2004)
10.1016/J.MAM.2004.02.014
Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease.
M. Carreras (2004)
10.1038/nri1312
NOX enzymes and the biology of reactive oxygen
J. Lambeth (2004)
10.1074/JBC.M407715200
Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane*
F. Muller (2004)
10.1523/JNEUROSCI.1899-04.2004
Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species
A. Starkov (2004)
10.1074/jbc.M404421200
Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo
M. Zou (2004)
10.1042/BJ20041683
Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase.
P. Iñarrea (2005)
10.1098/rstb.2005.1764
Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress
L. Tretter (2005)
10.1016/J.FREERADBIOMED.2005.02.026
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling.
S. Rhee (2005)
10.1016/J.BBABIO.2006.02.010
Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol.
A. Boveris (2006)
10.1083/jcb.200605036
Specificity in reactive oxidant signaling: think globally, act locally
L. Terada (2006)
10.1016/J.MITO.2006.07.008
Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells.
A. Bácsi (2006)
10.1007/978-3-211-33328-0_8
Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection.
M. Naoi (2006)
10.1126/SCIENCE.1130481
H2O2, a Necessary Evil for Cell Signaling
S. Rhee (2006)
10.1134/S0006297906010093
Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal
O. Y. Pletjushkina (2006)
10.2741/2128
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome.
C. Gómez (2007)
10.1042/BJ20061809
Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis.
P. Iñarrea (2007)
10.1128/MCB.01338-07
Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis
Robert D Guzy (2007)
10.1089/ARS.2007.1677
On the biologic role of the reaction of NO with oxidized cytochrome c oxidase.
F. Antunes (2007)
10.1152/AJPCELL.00310.2006
Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiology.
C. Cooper (2007)
10.1111/j.1471-4159.2006.04223.x
Characteristics of α‐glycerophosphate‐evoked H2O2 generation in brain mitochondria
L. Tretter (2007)
10.1002/iub.116
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants
O. Cantoni (2008)
10.1111/j.1471-4159.2007.04957.x
c‐Jun N‐terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons
Qiongqiong Zhou (2008)
10.1016/S1474-4422(07)70327-7
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
A. Schapira (2008)
10.1016/j.bbamcr.2007.12.002
Mitochondrial H2O2 limits U937 cell survival to peroxynitrite by promoting ERK1/2 dephosphorylation.
L. Cerioni (2008)
10.1002/iub.46
Brain mitochondrial dysfunction in aging
A. Boveris (2008)
10.1371/journal.pone.0002379
Tumor Cell Phenotype Is Sustained by Selective MAPK Oxidation in Mitochondria
Soledad Galli (2008)
10.1016/j.freeradbiomed.2008.03.011
Redox-based regulation of signal transduction: principles, pitfalls, and promises.
Y. Janssen-Heininger (2008)
10.1016/j.febslet.2009.02.043
Activation of c‐Jun‐N‐terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging
Qiongqiong Zhou (2009)
10.1523/JNEUROSCI.1706-09.2009
Mitochondria Are the Source of Hydrogen Peroxide for Dynamic Brain-Cell Signaling
L. Bao (2009)
10.1042/BJ20081386
How mitochondria produce reactive oxygen species
M. Murphy (2009)
10.1074/jbc.M808981200
Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III*
Y. H. Noh (2009)
10.1016/j.freeradbiomed.2009.03.007
Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies.
A. Navarro (2009)
10.1080/10715760902849813
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production
P. Y. Lam (2009)



Semantic Scholar Logo Some data provided by SemanticScholar