Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Characterization Of Nanoparticles In Dermal Formulations
D. Knoth, R. Eckert, Steffen F. Hartmann, Cornelia M. Keck
Published 2019 · Materials Science
Save to my Library
Download PDFAnalyze on Scholarcy
The characterization of nanoparticles in dermal formulations is challenging and there are several different aims to characterize nanoparticles in their respective dermal formulations. The major aim will be to observe the stability of the nanoparticles, i.e., to monitor if size, crystalline state, distribution of the particles within the vehicle and/ or incorporation of the actives are maintained during the shelf life of the product. Another reason to characterize nanoparticles in dermal products might be derived from regulatory bodies, which might be interested to determine if a dermal product contains nanoparticles or not. Due to the diverse nature of the different nanocarriers being available today and due to the diverse characterization aims no standard procedure is available for this. Hence, for each type of formulations an individual analysis protocol needs to be established. The aim of this chapter is to provide a brief overview of the existing methods for the characterization of nanoparticles in dermal formulations and to provide basic information on how to characterize nanoparticles in dermal formulations on a day to day basis.
This paper references
Importance of the physicochemical properties of fluorescent dyes for obtaining target-specific in vivo images by membrane-permeable macromolecular imaging probes
T. Kuchimaru (2013)
Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin
M. Radbruch (2017)
X-Ray Diffraction Crystallography
Y. Waseda (2011)
The application of STEP‐technology® for particle and protein dispersion detection studies in biopharmaceutical research
J. Gross-Rother (2018)
Characterization of indomethacin-loaded lipid nanoparticles by differential scanning calorimetry.
F. Castelli (2005)
Particle Size Distribution by Space or Time Dependent Extinction Profiles obtained by Analytical Centrifugation
T. Detloff (2006)
Small Angle X-ray Scattering for Nanoparticle Research.
T. Li (2016)
Detection and characterization of engineered nanoparticles in food and the environment
K. Tiede (2008)
Formulation and Evaluation of Lidocaine Lipid Nanosystems for Dermal Delivery
P. Pathak (2009)
Analysis of titanium dioxide and zinc oxide nanoparticles in cosmetics.
P. Lu (2015)
Capturing the Freeze-Drying Dynamics of NaCl Nanoparticles Using THz Spectroscopy.
Katsuhiro Ajito (2018)
Time-Resolved Fluorescence Spectroscopy and Fluorescence Lifetime Imaging Microscopy for Characterization of Dendritic Polymer Nanoparticles and Applications in Nanomedicine
A. Boreham (2016)
Preparation and characterization of quercetin nanocrystals.
N. G. Sahoo (2011)
Industrial concentrates of dermal hesperidin smartCrystals®--production, characterization & long-term stability.
Gregori B. Romero (2015)
Penetration of normal, damaged and diseased skin--an in vitro study on dendritic core-multishell nanotransporters.
N. Alnasif (2014)
Gel network shampoo formulation and hair health benefits
J. Marsh (2017)
Preparation and Structure of a Water‐in‐Oil Cream Containing Lipid Nanoparticles
T. D. Vringer (1995)
Characterization of nanoparticles in diluted clear solutions for Silicalite-1 zeolite synthesis using liquid 29Si NMR, SAXS and DLS.
L. Follens (2008)
Characterizing size and porosity of hollow nanoparticles: SAXS, SANS, TEM, DLS, and adsorption isotherms compared.
Z. Chen (2012)
Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery.
Qingzhi Lv (2009)
Laser diffractometry of nanoparticles: frequent pitfalls & overlooked opportunities
Senem Acar Kübart (2013)
Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin.
A. Edlich (2018)
x Ray crystallography
M. S. Smyth (2015)
Self-assembled nanostructured aqueous dispersions as dermal delivery systems.
M. Hoppel (2015)
Interactions of hyaluronic Acid with the skin and implications for the dermal delivery of biomacromolecules.
M. Witting (2015)
SLN and NLC for topical delivery of antifungals
E. Souto (2005)
Characterization of titanium dioxide and zinc oxide nanoparticles in sunscreen powder by comparing different measurement methods.
P. Lu (2018)
Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods
F. Varenne (2016)
Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs
A. R. Fernandes (2017)
Anti‐inflammatory and anti‐cancer activity of citral: Optimization of citral‐loaded solid lipid nanoparticles (SLN) using experimental factorial design and LUMiSizer®
A. Zielińska (2018)
Penetration of silver nanoparticles into porcine skin ex vivo using fluorescence lifetime imaging microscopy, Raman microscopy, and surface-enhanced Raman scattering microscopy
Yongjian Zhu (2015)
Long-Term Stability of n-Alkane-in-Water Pickering Nanoemulsions: Effect of Aqueous Solubility of Droplet Phase on Ostwald Ripening
K. L. Thompson (2018)
Hydroxyethyl methacrylate grafted carboxy methyl tamarind (CMT-g-HEMA) polysaccharide based matrix as a suitable scaffold for skin tissue engineering.
Priyanka Choudhury (2018)
Correction: Understanding the role of co-surfactants in microemulsions on the growth of copper oxalate using SAXS.
Nanocarriers for antioxidant resveratrol: formulation approach, vesicle self-assembly and stability evaluation.
C. Caddeo (2013)
Time‐resolved fluorescence microscopy (FLIM) as an analytical tool in skin nanomedicine
U. Alexiev (2017)
20 Years of Lipid Nanoparticles (SLN & NLC): Present State of Development & Industrial Applications
R. Mueller (2011)
Synthesis, Characterization, and Pickering Emulsifier Performance of Anisotropic Cross-Linked Block Copolymer Worms: Effect of Aspect Ratio on Emulsion Stability in the Presence of Surfactant.
S. J. Hunter (2019)
Nanotoxicological classification system (NCS) - a guide for the risk-benefit assessment of nanoparticulate drug delivery systems.
C. Keck (2013)
Cubosomes for topical delivery of the antimicrobial peptide LL‐37
Lukas Boge (2019)
Particle size analysis of nanocrystals: improved analysis method.
C. Keck (2010)
Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect.
J. Pardeike (2010)
Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization
E. Souto (2006)
Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products.
A. Dingler (1999)
Impact of the ceramide subspecies on the nanostructure of stratum corneum lipids using neutron scattering and molecular dynamics simulations. Part I: impact of CER[NS].
T. Schmitt (2018)
Exploiting Fluorescence Lifetime Plasticity in FLIM: Target Molecule Localization in Cells and Tissues.
A. Boreham (2011)
Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids.
V. Jenning (2000)
Visualizing Oxidative Cellular Stress Induced by Nanoparticles in the Subcytotoxic Range Using Fluorescence Lifetime Imaging.
Jens Balke (2018)
Grundlegende Untersuchungen zur Arzneistoffinkorporation, -freisetzung und Struktur von SLN und NLC
M. Radtke (2003)
Size analysis of submicron particles by laser diffractometry--90% of the published measurements are false.
C. Keck (2008)
The influence of flaxseed gum on the microrheological properties and physicochemical stability of whey protein stabilized β-carotene emulsions.
Duoxia Xu (2017)
Super-resolved fluorescence microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner.
L. Möckl (2014)
Optimization of linalool‐loaded solid lipid nanoparticles using experimental factorial design and long‐term stability studies with a new centrifugal sedimentation method
I. Pereira (2018)
SLN and NLC for topical delivery of ketoconazole
E. Souto (2005)
Identification and characterization of organic nanoparticles in food
R. Peters (2011)
Development of novel cosmetic base using sterol surfactant. I. Preparation of novel emulsified particles with sterol surfactant+.
T. Oka (2008)
Internally self-assembled particles entrapped in thermoreversible hydrogels.
S. Guillot (2009)
Electron Microscopy And Analysis
P. Goodhew (1975)
Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques
A. Ostrowski (2015)
Phase separation in ceramide[NP] containing lipid model membranes: neutron diffraction and solid-state NMR.
A. Schroeter (2017)
Study of the crystallization and polymorphic structures formed in oleogels from avocado oil
E. J. Pérez-Monterroza (2016)
Self-Assembly of Triglyceride Nanocrystals in Suspension
T. Unruh (2002)
Ultrasound-based formation of nano-Pickering emulsions investigated via in-situ SAXS.
Yi-ting Lee (2019)
Novel nanosized formulations of two diclofenac acid polymorphs to improve topical bioavailability.
R. Pireddu (2015)
Stability determination of the formulations containing hyaluronic acid
A. Olejnik (2015)
Pitfalls in using fluorescence tagging of nanomaterials: tecto‐dendrimers in skin tissue as investigated by Cluster‐FLIM
P. Volz (2017)
Electron Paramagnetic Resonance and Small-Angle X-ray Scattering Characterization of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Dibucaine Encapsulation.
Raquel M Barbosa (2018)
Investigating the origins of nanostructural variations in differential ethnic hair types using X‐ray scattering techniques
M. Wade (2013)
Synthesis of specific deuterated derivatives of the long chained stratum corneum lipids [EOS] and [EOP] and characterization using neutron scattering.
Stefan Sonnenberger (2017)
Physicochemical and acid gelation properties of commercial UHT-treated plant-based milk substitutes and lactose free bovine milk.
O. Mäkinen (2015)
The use of differential scanning calorimetry as a tool to characterize liposome preparations
R. Biltonen (1993)
Nanoparticles: a global vision. Characterization, separation, and quantification methods. Potential environmental and health impact
A. López-Serrano (2014)