Online citations, reference lists, and bibliographies.
← Back to Search

Involvement Of Type A Monoamine Oxidase In Neurodegeneration: Regulation Of Mitochondrial Signaling Leading To Cell Death Or Neuroprotection.

M. Naoi, W. Maruyama, Y. Akao, H. Yi, Y. Yamaoka
Published 2006 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
In neurodegenerative diseases, including Parkinson's and Alzheimer's diseases, apoptosis is a common type of cell death, and mitochondria emerge as the major organelle to initiate death cascade. Monoamine oxidase (MAO) in the mitochondrial outer membrane produces hydrogen peroxide by oxidation of monoamine substrates, and induces oxidative stress resulting in neuronal degeneration. On the other hand, a series of inhibitors of type B MAO (MAO-B) protect neurons from cell death. These results suggest that MAO may be involved in the cell death process initiated in mitochondria. However, the direct involvement of MAO in the apoptotic signaling has been scarcely reported. In this paper, we present our recent results on the role of MAO in activating and regulating cell death processing in mitochondria. Type A MAO (MAO-A) was found to bind an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, and induce apoptosis in dopaminergic SH-SY5Y cells containing only MAO-A. To examine the intervention of MAO-B in apoptotic process, human MAO-B cDNA was transfected to SH-SY5Y cells, but the sensitivity to N-methyl(R)salsolinol was not affected, even though the activity and protein of MAO-B were expressed markedly. MAO-B oxidized dopamine with production of hydrogen peroxide, whereas in control cells expressing only MAO-A, dopamine autoxidation produced superoxide and dopamine-quinone, and induced mitochondrial permeability transition and apoptosis. Rasagiline and other MAO-B inhibitors prevent the activation of apoptotic cascade and induce prosurvival genes, such as bcl-2 and glial cell line-derived neurotrophic factor, in MAO-A-containing cells. These results demonstrate a novel function of MAO-A in the induction and regulation of apoptosis. Future studies will clarify more detailed mechanism behind regulation of mitochondrial death signaling by MAO-A, and bring out new strategies to cure or ameliorate the decline of neurons in neurodegenerative disorders.
This paper references
A rapid microfluorimetric determination of monoamine oxidase.
M. Krajl (1965)
Alkaloids in mammalian tissues. 2. Synthesis of (+)-and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines.
S. Teitel (1972)
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
M. M. Bradford (1976)
Studies on the Oxidation of the Dopaminergic Neurotoxin 1‐Methyl‐4‐Phenyl‐1,2,5,6‐Tetrahydropyridine by Monoamine Oxidase B
R. Heikkila (1985)
Localization of distinct monoamine oxidase a and monoamine oxidase b cell populations in human brainstem
K. Westlund (1988)
cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.
A. Bach (1988)
Expression of Functional Human Monoamine Oxidase A and B cDNAs in Mammalian Cells
N. C. Lan (1989)
Oxidative stress: a role in the pathogenesis of Parkinson's disease.
M. Götz (1990)
Monoamine oxidase A gene and bipolar affective disorder.
L. C. Lim (1994)
Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.
O. Cases (1995)
Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine
VP Bindokas (1996)
Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies
M. Naoi (1996)
Does monoamine oxidase type B play a role in dopaminergic nerve cell death in Parkinson's disease?
P. Damier (1996)
A dopaminergic neurotoxin, (R)‐N‐methylsalsolinol, increases in parkinsonian cerebrospinal fluid
W. Maruyama (1996)
Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species.
J. Crow (1997)
Predominant expression of monoamine oxidase B isoform in rabbit renal proximal tubule: regulation by I2 imidazoline ligands in intact cells.
C. Gargalidis-Moudanos (1997)
Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow.
G. Cohen (1997)
An Endogenous Dopaminergic Neurotoxin, N‐Methyl‐(R)‐Salsolinol, Induces DNA Damage in Human Dopaminergic Neuroblastoma SH‐SY5Y Cells
W. Maruyama (1997)
(R) salsolinol N‐methyltransferase activity increases in parkinsonian lymphocytes
M. Naoi (1998)
Protection against apoptosis by monoamine oxidase A inhibitors
W. Malorni (1998)
The mitochondrial permeability transition pore and its role in cell death.
M. Crompton (1999)
Monoamine oxidase: from genes to behavior.
J. C. Shih (1999)
Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis
S. Desagher (1999)
Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat.
M. Carrillo (2000)
Rasagiline [N‐propargyl‐1R(+)‐aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
M. Youdim (2001)
Transfection‐enforced Bcl‐2 overexpression and an anti‐Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde‐3‐phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol
W. Maruyama (2001)
Elevated vulnerability to oxidative stress‐induced cell death and activation of caspase‐3 by the Swedish amyloid precursor protein mutation
A. Eckert (2001)
Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine
W. Maruyama (2001)
Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway
G. D. De Zutter (2001)
Antiapoptotic Properties of Rasagiline, N‐Propargylamine‐1(R)‐aminoindan, and Its Optical (S)‐Isomer, TV1022
W. Maruyama (2001)
Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines
M. Naoi (2002)
Tyramine and Monoamine Oxidase Inhibitors as Modulators of the Mitochondrial Membrane Permeability Transition
L. Marcocci (2002)
Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease.
M. Naoi (2002)
An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells
Y. Akao (2002)
Mitochondrial permeability transition mediates apoptosis induced by N‐methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl‐2 and rasagiline, N‐propargyl‐1(R)‐aminoindan
Y. Akao (2002)
Decreased Methylation and Transcription Repressor Sp3 Up-regulated Human Monoamine Oxidase (MAO) B Expression during Caco-2 Differentiation*
W. K. Wong (2003)
The Pathophysiology of Mitochondrial Cell Death
D. Green (2004)
Molecular pathways to neurodegeneration
Ella Bossy-Wetzel (2004)
A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease.
A. Siderowf (2004)
Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains.
M. Naoi (2004)
Oxidative stress in neurodegeneration: cause or consequence?
J. Andersen (2004)
N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-κB transcription factor
W. Maruyama (2004)
Monoamine oxidases: certainties and uncertainties.
K. F. Tipton (2004)
The deamination of dopamine by human brain monoamine oxidase
A. O'Carroll (2004)
Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline.
M. Youdim (2005)
Rasagiline: Neurodegeneration, neuroprotection, and mitochondrial permeability transition
M. Youdim (2005)
N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2
H. Yi (2005)
Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol, leading to apoptosis in SH‐SY5Y cells
H. Yi (2006)
Oxidative stress in mitochondria
M. Naoi (2007)

This paper is referenced by
Recent Development of Reactional Small-Molecule Fluorescent Probes Based on Resorufin
Han Wang (2021)
Carboxylated single-wall carbon nanotubes decorated with SiO2 coated-Nd2O3 nanoparticles as an electrochemical sensor for L-DOPA detection
Slađana Đurđić (2021)
Mitochondrial reactive oxygen species in physiology and disease.
Salvatore Antonucci (2021)
Monoamine Oxidase A (MAO-A): A Therapeutic Target in Lung Cancer
Chandreyee Datta (2021)
Synthesis of polyhydroquinolines and propargylamines through one-pot multicomponent reactions using an acidic ionic liquid immobilized onto magnetic Fe3O4 as an efficient heterogeneous catalyst under solvent-free sonication
H. Nguyen (2020)
Simultaneously Detecting Monoamine Oxidase A and B in Disease Cell/Tissue Samples Using Paper-Based Devices
Haixiao Fang (2020)
Utility of Reactive Species Generation in Plasma Medicine for Neuronal Development
S. Mitra (2020)
Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Agent for Selective Cytotoxicity.
Toghrul Almammadov (2020)
Rational Design of Two-photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues.
Haixiao Fang (2020)
Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer’s Disease
Kan Yin Wong (2020)
Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamine-induced amnesic rats.
B. Adedayo (2020)
The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD
Hyunhee Park (2020)
Effects of combined arsenic and lead exposure on the brain monoaminergic system and behavioral functions in rats: Reversal effect of MiADMSA
S. Saritha (2019)
Progress in Target Drug Molecules for Alzheimer's Disease.
Jiayang Xie (2019)
Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo.
Zhengmin Yang (2019)
Lead (Pb) exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans: Involvement of the dopamine transporter
A. J. Akinyemi (2019)
Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission
J. Korábečný (2018)
Neuroprotective effects of selegiline on rat neural stem cells treated with hydrogen peroxide.
A. Abdanipour (2018)
Role of Monoamine oxidase A (MAO-A) in cancer progression and metastasis
A. Bhattacharjee (2018)
Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13–stimulated monocytes and A549 lung carcinoma cells
Sukhamoy Dhabal (2018)
Why does the Y326I mutant of monoamine oxidase B decompose an endogenous amphetamine at a slower rate than the wild type enzyme? Reaction step elucidated by multiscale molecular simulations.
Domen Pregeljc (2018)
Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells
F. Ciccarese (2017)
Neuronal signaling repertoire in the mammalian sperm functionality
A. Ramírez-Reveco (2017)
A Strategy for Specific Fluorescence Imaging of Monoamine Oxidase A in Living Cells.
X. Wu (2017)
Towards a Pathway Inventory of the Human Brain for Modeling Disease Mechanisms Underlying Neurodegeneration.
A. Iyappan (2016)
Progress in drug development for Alzheimer's disease: An overview in relation to mitochondrial energy metabolism.
J. Hroudová (2016)
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration
R. Ramsay (2016)
Rasagiline and selegiline suppress calcium efflux from mitochondria by PK11195-induced opening of mitochondrial permeability transition pore: a novel anti-apoptotic function for neuroprotection
Yuqiu Wu (2015)
A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson's Disease.
Lin Li (2015)
Synthesis and Biological Evaluation of 2-Phenoxyacetamide Analogues, a Novel Class of Potent and Selective Monoamine Oxidase Inhibitors
Wei Shen (2014)
Synthesis and Biological Evaluation of 2-Phenoxyacetamide Analogues, a Novel Class of Potent and Selective Monoamine
Wei Shen (2014)
Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?
A. Markham (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar