Online citations, reference lists, and bibliographies.
← Back to Search

Chemical Component Separation Using Botulinum Toxin

M. López-Cano, M. Armengol-Carrasco
Published 2016 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
“Chemical Component Separation” is a novel concept that involves the application botulinum neurotoxin A (BoNT-A), a potent muscle-paralyzing agent, to achieve muscle relaxation of the abdominal wall muscles as an aid in the surgical repair of complex ventral and incisional hernias and for facilitating closure of midline abdominal wall defects. However, the number of clinical studies is limited and the experience with the application of BoNT-A in the field abdominal wall surgery is still preliminary. Achievement of tension- and retraction-free conditions in complex abdominal wall reconstruction is the main objective taking advantage of BoNT-A-related paralysis of abdominal wall muscles following injections in selected points on both sides of the abdomen. Better postoperative pain control and reduction of opioid analgesia are related to the antinociceptive effects of BoNT-A. Recommended techniques to guide botulinum toxin injection include electromyography, electric nerve stimulation, ultrasound, and anatomical localization. Formulations are not interchangeable. Potential applications of BoNT-A in adult patients may include complex and non-complex midline incisional hernias with loss of domain, open abdomen, or reconstructions when the abdominal wall is intact, with or without preoperative progressive pneumoperitoneum. Further studies, preferably randomized-controlled designs are necessary to clarify a number of relevant clinical questions, including patient’s eligibility, dosing of the different botulinum A formulations, optimal administration technique, or benefits of potential association with other procedures. The evidence available at the present time is still weak and a clear role of BoNT-A in abdominal wall surgery remains to be defined.
This paper references
10.1002/mds.22336
Respective potencies of Botox® and Dysport® in a human skin model: A randomized, double‐blind study
G. Kranz (2009)
10.1186/2046-4053-2-40
A comparative assessment of three formulations of botulinum toxin A for facial rhytides: a systematic review and meta-analyses
J. Bonaparte (2013)
10.1111/j.1365-2133.2010.10085.x
Long‐term efficacy and respective potencies of botulinum toxin A and B: a randomized, double‐blind study
G. Kranz (2011)
10.1016/J.REHAH.2014.06.002
Toxina botulínica A como adyuvante en hernia inguinoescrotal bilateral con pérdida de domicilio. Informe del primer caso y revisión bibliográfica
T. R. I. Hurtado (2014)
10.2174/0929867043363802
Botulinum toxin: a successful therapeutic protein.
K. Aoki (2004)
10.1016/J.JPEDSURG.2005.12.023
Effect of paralysis of the abdominal wall muscles by botulinum A toxin to intraabdominal pressure: an experimental study.
M. Çakmak (2006)
10.1007/978-3-319-05470-4_10
Meta-analysis, Evidence-Based Medicine, and Clinical Guidelines
S. Glasser (2014)
10.1007/s00268-013-2211-6
Outcomes of Chemical Component Paralysis Using Botulinum Toxin for Incisional Hernia Repairs
B. Zendejas (2013)
10.1007/s00268-009-0203-3
Use of Botulinum Toxin Type A Before Abdominal Wall Hernia Reconstruction
T. R. Ibarra-Hurtado (2009)
10.1111/j.1468-1331.2006.01649.x
Using translational medicine to understand clinical differences between botulinum toxin formulations
K. Aoki (2006)
10.1002/MDS.870090106
Histologic assessment of dose‐related diffusion and muscle fiber response after therapeutic botulinum a toxin injections
G. Borodic (1994)
10.1136/jnnp.72.4.459
Respective potencies of Botox and Dysport: a double blind, randomised, crossover study in cervical dystonia
D. Ranoux (2002)
10.1007/s10029-014-1280-2
Effect of botulinum toxin type A in lateral abdominal wall muscles thickness and length of patients with midline incisional hernia secondary to open abdomen management
T. R. Ibarra-Hurtado (2014)
10.1097/01.PRS.0000396869.71673.AD
182: CHEMICAL MYOTOMY WITH BOTULINUM TOXIN FOR ABDOMINAL WALL RECONSTRUCTION: A PORCINE PILOT STUDY
K. Harth (2011)
10.1002/mds.20022
Clinical presentation and management of antibody‐induced failure of botulinum toxin therapy
D. Dressler (2004)
10.1002/mds.20003
Historical notes on botulism, Clostridium botulinum, botulinum toxin, and the idea of the therapeutic use of the toxin
F. Erbguth (2004)
10.1177/2042533312472115
An evidence-based review of botulinum toxin (Botox) applications in non-cosmetic head and neck conditions
R. Persaud (2013)
10.1212/WNL.40.7.1143
Brachial plexopathy after botulinum toxin injections
R. L. Glanzman (1990)
Relative potency of incobotulinumtoxinA vs onabotulinumtoxinA a meta-analysis of key evidence.
R. Jandhyala (2012)
10.1136/jnnp.62.2.198
Generalised botulism-like syndrome after intramuscular injections of botulinum toxin type A: a report of two cases.
A. Bakheit (1997)
10.1111/j.1526-4637.2011.01147.x
Botox A injection for pain after laparoscopic ventral hernia: a case report.
D. Smoot (2011)
10.1111/j.1468-1331.2006.01648.x
The structure and mode of action of different botulinum toxins
J. O. Dolly (2006)
10.1001/ARCHDERM.140.11.1351
Effect of volume and concentration on the diffusion of botulinum exotoxin A.
T. Hsu (2004)
10.1016/S2255-2677(13)70005-7
Cirugía basada en la evidencia y hernia incisional
M. López-Cano (2013)
10.1007/s10029-012-0995-1
Chemical components separation with botulinum toxin A: a novel technique to improve primary fascial closure rates of the open abdomen
M. Zielinski (2012)
10.1038/EYE.1998.9
Necrotising fasciitis as a complication of botulinum toxin injection
P. Latimer (1998)
10.1002/mds.20008
Retargeted clostridial endopeptidases: Inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain
J. Chaddock (2004)
10.1001/ARCHNEUR.1991.00530240057020
Clinical correlates of response to botulinum toxin injections.
J. Jankovic (1991)
10.1002/MDS.870090216
Development of resistance to botulinum toxin type A in patients with torticollis
P. Greene (1994)
10.1016/J.REHAH.2014.06.001
Resultado de la aplicación preoperatoria de toxina botulínica A en el tratamiento de hernias incisionales gigantes
Karla Verónica Chávez-Tostado (2014)
10.4240/wjgs.v5.i12.314
"Acute postoperative open abdominal wall": Nosological concept and treatment implications.
M. López-Cano (2013)
10.1007/S11883-001-0022-Y
Botulinum toxin for the management of muscle overactivity and spasticity after stroke
A. Esquenazi (2001)
10.1046/j.1468-1331.2001.00035.x
Botulinum toxin type A and other botulinum toxin serotypes: a comparative review of biochemical and pharmacological actions
K. Aoki (2001)
10.1097/01.IOP.0000217703.80859.A3
Immunologic resistance after repeated botulinum toxin type a injections for facial rhytides.
Gary Borodic (2006)
10.1504/TBJ.2008.018956
Biochemical, functional and potency characteristics of type A botulinum toxin in clinical use
N. Panjwani (2008)
10.1097/PRS.0b013e318170813c
Comparisons among Botulinum Toxins: An Evidence-Based Review
A. Klein (2008)
Evidence based medicine: What it is and what it isn't (reprinted from BMJ, vol 312, pg 71-72, 1996)
D. Sackett (2007)
10.1136/jnnp.59.6.601
Botulinum toxin F in the treatment of torticollis clinically resistant to botulinum toxin A.
G. Sheean (1995)
10.1111/j.1524-4725.2010.01710.x
Antibody‐Induced Failure of Botulinum Toxin A Therapy in Cosmetic Indications
D. Dressler (2010)
10.1002/mds.20002
Basic and therapeutic aspects of neurotonins
H. Bigalke (2004)
10.1007/s10029-012-1021-3
Comment to: Chemical components separation with botulinum toxin A: a novel technique to improve primary fascial closure rates of the open abdomen by Zielinski et al.
T. R. Ibarra-Hurtado (2012)
10.1016/0140-6736(93)91580-F
Gallbladder dysfunction induced by botulinum A toxin
P. Schnider (1993)
10.1111/j.1468-1331.2006.01444.x
Management of spasticity in adults: practical application of botulinum toxin
M. Pathak (2006)
10.3109/9780203450321-49
Therapy with botulinum toxin
J. Jankovic (1994)
10.1097/00004397-198602640-00021
Botulinum in the treatment of adult motility disorders.
R. Hoffman (1986)
10.1136/BMJ.312.7023.71
Evidence based medicine: what it is and what it isn't
D. Sackett (1996)
10.1111/j.1473-2165.2008.00361.x
Different formulations of botulinum toxin type A have different migration characteristics: a double‐blind, randomized study
S. Cliff (2008)
10.1007/s00268-007-9222-0
Vacuum-assisted Wound Closure and Mesh-mediated Fascial Traction—A Novel Technique for Late Closure of the Open Abdomen
U. Petersson (2007)
10.1007/s10029-013-1168-6
Criteria for definition of a complex abdominal wall hernia
N. Slater (2013)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar