Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Chemical And Physical Elicitation For Enhanced Cannabinoid Production In Cannabis

Jonathan Gorelick, N. Bernstein
Published 2017 · Biology

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Of the many medicinal plants with therapeutic potential, Cannabis sativa is, by far, the most promising in the near future for large scale utilization. However, the inherent chemical variability of plant based medicines must be addressed, before cannabis can be incorporated into modern medical practices. This chemical variability can only be controlled and potentially optimized if the underlying causes of the production of therapeutic compounds in cannabis is adequately understood. Many of the medically useful compounds produced by plants are the result of the plant stress response. Although not completely clear, there is a significant body of evidence suggesting a similar role for cannabinoids. Cannabinoids are implicating in both, biotic and abiotic stresses, including thermal, nutrient, and water stress, photoradiation, as well as bacterial and fungal pathogens. This chapter will explore the possible ecological roles of cannabinoids in cannabis and the potential utilization of these roles via biotic or abiotic elicitors.
This paper references
10.1016/S1360-1385(98)01364-8
Salicylic acid-independent plant defence pathways.
Pieterse (1999)
10.1111/ppl.12318
Cold acclimation induces distinctive changes in the chromatin state and transcript levels of COR genes in Cannabis sativa varieties with contrasting cold acclimation capacities.
Boris F. Mayer (2015)
10.1016/0305-1978(75)90036-8
Photosynthesis and cannabinoid content of temperate and tropical populations of Cannabis sativa
F. Bazzaz (1975)
10.1007/BF00621336
An antibacterial preparatum from hemp (Cannabis sativa L.)
L. Ferenczy (2004)
10.1007/s10725-004-2604-5
Growth, metabolic profiling and enzymes activities of Catharanthus roseus seedlings treated with plant growth regulators
M. El-Sayed (2004)
Influence of fertilization and drought stress on the growth and production of secondary metabolites in Prunella vulgaris L.
Yu-hang Chen (2011)
10.1021/bp980029v
Effect of Elicitor Dosage and Exposure Time on Biosynthesis of Indole Alkaloids by Catharanthus roseus Hairy Root Cultures
S. K. Rijhwani (1998)
10.1021/jf9011246
Elicitation of pharmacologically active substances in an intact medical plant.
S. Kužel (2009)
10.1007/s11103-008-9435-0
Role of plant hormones in plant defence responses
R. Bari (2008)
10.1016/j.jbiotec.2009.05.006
Elicitation studies in cell suspension cultures of Cannabis sativa L.
I. J. Flores-Sánchez (2009)
10.1007/S00217-005-0011-4
Effect of cultivars and deep freeze storage on saponin content of white asparagus spears (Asparagus officinalis L.)
Anita Schwarzbach (2005)
10.1007/BF02904200
Possible role of ultraviolet radiation in evolution ofCannabis chemotypes
D. Pate (2008)
10.1007/978-90-481-2666-8_53
Effect of metal toxicity on plant growth and metabolism: I. Zinc
G. R. Rout (2003)
10.1038/nrd1495
The endocannabinoid system and its therapeutic exploitation
V. Marzo (2004)
10.1073/PNAS.0504187103
Peripheral cannabinoid receptor, CB2, regulates bone mass.
O. Ofek (2006)
10.1021/np8002673
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
G. Appendino (2008)
10.1038/266650A0
Storage of cannabinoids by Arctia caja and Zonocerus elegans fed on chemically distinct strains of Cannabis sativa
M. Rothschild (1977)
10.1021/NP50008A001
Constituents of Cannabis sativa L. XVII. A review of the natural constituents.
C. E. Turner (1980)
10.1007/s13225-012-0216-3
Endophytic fungi harbored in Cannabis sativa L.: diversity and potential as biocontrol agents against host plant-specific phytopathogens
P. Kusari (2012)
10.1002/ARCH.940170404
Influence of light on plant allelochemicals : a synergistic defense in higher plants
Kelsey R. Downum (1991)
Effect of the climate on the content of a CBD-rich variant of cannabis
H. Hakim (1986)
10.1016/j.phytochem.2015.02.029
Hypoglycemic activity of withanolides and elicitated Withania somnifera.
Jonathan Gorelick (2015)
10.2307/2484942
Altitudinal Variation in Leaf Epidermal Patterns of Cannabis sativa
G. Sharma (1975)
10.1007/s00253-014-5807-3
Quorum quenching is an antivirulence strategy employed by endophytic bacteria
P. Kusari (2014)
10.1016/S0168-9452(00)00306-X
Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis.
Lindén (2000)
10.1177/1934578X1200700628
Herbal Medicine in Healthcare-An Overview
M. Mosihuzzaman (2012)
10.1007/BF02863315
Seasonal fluctuations in cannabinoid content of Kansas Marijuana
R. Latta (2008)
10.1111/j.1469-8137.2008.02511.x
Gibberellins, jasmonate and abscisic acid modulate the sucrose-induced expression of anthocyanin biosynthetic genes in Arabidopsis.
E. Loreti (2008)
10.1016/J.PLAPHY.2005.07.013
Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John's wort.
S. M. A. Zobayed (2005)
10.1007/s10535-005-0051-4
Cannabis sativa L. growing on heavy metal contaminated soil: growth, cadmium uptake and photosynthesis
P. Linger (2005)
10.1016/j.tplants.2009.03.006
The multifaceted role of ABA in disease resistance.
J. Ton (2009)
Influence of environmental conditions on tetrahydrocannabinol (Delta ('9) TCH) in different cultivars on Cannabis sativa L.
G. Murari (1983)
10.1007/BF00166846
Induction of ajmalicine formation and related enzyme activities in Catharanthus roseus cells: effect of inoculum density
P. R. Moreno (2004)
10.1039/A703973E
From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis.
R. Mechoulam (1999)
10.3390/molecules190914004
Study of Leaf Metabolome Modifications Induced by UV-C Radiations in Representative Vitis, Cissus and Cannabis Species by LC-MS Based Metabolomics and Antioxidant Assays
G. Marti (2014)
10.1523/JNEUROSCI.1636-07.2007
Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex
F. Bambico (2007)
10.1111/j.1365-3040.2011.02381.x
Crosstalk between abiotic ultraviolet-B stress and biotic (flg22) stress signalling in Arabidopsis prevents flavonol accumulation in favor of pathogen defence compound production.
Dirk Schenke (2011)
10.1007/BF02872989
Quantitative variation in the chemical constituents of marihuana from stands of naturalizedCannabis sativa L. in East-Central Illinois
A. Haney (2008)
10.1104/PP.116.3.979
Reduction of light-induced anthocyanin accumulation in inoculated sorghum mesocotyls. Implications for a compensatory role in the defense response.
S. Lo (1998)
10.1007/978-1-60761-723-5_1
Plant secondary metabolism and challenges in modifying its operation: an overview.
Naíla Cannes do Nascimento (2010)
10.1007/s10725-009-9375-y
Effects of ABA on primary terpenoids and Δ9-tetrahydrocannabinol in Cannabis sativa L. at flowering stage
H. Mansouri (2009)
10.1021/JM020359T
Elicitation, a new window into plant chemodiversity and phytochemical drug discovery.
A. Poulev (2003)
10.1111/J.1399-3054.1995.TB05524.X
Induction of phenylpropanoid and tyramine metabolism in pectinase‐ or pronase‐elicited cell suspension cultures of tobacco (Nicotiana tabacum)
J. Negrel (1995)
10.1093/AOB/MCG086
Effects of ultraviolet-B radiation on cotton (Gossypium hirsutum L.) morphology and anatomy.
V. Kakani (2003)
10.1017/S1462399409000957
Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation
G. Cabral (2009)
10.1146/ANNUREV.PP.40.060189.002023
Physiology and Molecular Biology of Phenylpropanoid Metabolism
K. Hahlbrock (1989)
10.1073/PNAS.92.1.2
The chemistry of defense: theory and practice.
M. Berenbaum (1995)
10.1016/S0261-2194(00)00134-4
Hemp diseases and pests. Management and biological control. An advanced treatise J.M. McPartland, R.C. Clarke and D.P. Watson; CABI Publishing Wallingford, Oxon, price £49.95 (US$90), ISBN 0-85199-454-7
D. Greathead (2001)
10.1094/MPMI-23-6-0791
Abscisic acid interacts antagonistically with salicylic acid signaling pathway in rice-Magnaporthe grisea interaction.
C. Jiang (2010)
10.1105/tpc.7.7.1085
Stress-Induced Phenylpropanoid Metabolism.
R. Dixon (1995)
10.1016/J.EJPHAR.2007.02.066
Role of cannabinoid CB2 receptors in glucose homeostasis in rats.
F. Bermúdez-Silva (2007)
10.1016/J.INDCROP.2008.08.002
Impact of fertilization on drought response in the medicinal herb Bupleurum chinense DC.: Growth and saikosaponin production
Z. Zhu (2009)
10.1146/annurev-arplant-042110-103854
Plant defense against herbivores: chemical aspects.
A. Mithöfer (2012)
10.1007/s10535-012-0033-2
Effects of abscisic acid on content and biosynthesis of terpenoids in Cannabis sativa at vegetative stage
H. Mansouri (2012)
10.1007/BF00436900
Pathogenicity of Phomopsis ganjae on Cannabis sativa and the fungistatic effect of cannabinoids produced by the host
J. McPartland (2004)
10.1007/BF00399444
Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol
B. Klingeren (2004)
10.1007/BF00034865
Effect of cadmium and nickel on photosynthesis and the enzymes of the photosynthetic carbon reduction cycle in pigeonpea (Cajanus cajan L.)
I. Sheoran (2004)
10.1016/S0141-0229(99)00137-4
The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida.
Pitta-Alvarez (2000)
10.1104/pp.107.1.1
The Biochemistry and Molecular Biology of Isoprenoid Metabolism
J. Chappell (1995)
10.1002/JPS.2600711204
Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds.
H. N. Eisohly (1982)
10.1078/0176-1617-00284
Umbelliferone, a stress metabolite of Chamomilla recutita (L.) Rauschert
M. Repčák (2001)
10.1515/znc-2004-7-817
Quantitative Changes of Secondary Metabolites of Matricaria chamomilla by Abiotic Stress
A. Eliašová (2004)
10.1146/ANNUREV.ARPLANT.52.1.689
DEFENSIVE RESIN BIOSYNTHESIS IN CONIFERS.
S. Trapp (2001)
10.1136/gut.2008.148791
Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects
A. Izzo (2008)
10.1080/15226514.2013.828018
Effective Phytoextraction of Cadmium (Cd) with Increasing Concentration of Total Phenolics and Free Proline in Cannabis sativa (L) Plant Under Various Treatments of Fertilizers, Plant Growth Regulators and Sodium Salt
A. Ahmad (2015)
10.1016/S1369-5266(03)00045-1
Jasmonates and related oxylipins in plant responses to pathogenesis and herbivory.
E. Farmer (2003)
10.1055/S-0033-1352335
LCMS Spectral Evidence of the Occurrence of Cannabinoid in Cannabis sativa Cell Cultures
S. Farag (2013)
10.1055/S-2006-959439
Long-Term Effect of a Pythium Elicitor Treatment on the Growth and Alkaloid Production of Catharanthus roseus Cell Suspensions.
C. Nef-Campa (1994)
10.1016/S0168-1656(00)00383-7
Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum.
J. Wu (2001)
10.1016/J.ENVEXPBOT.2009.08.005
EFFECT OF EXOGENOUS SALICYLIC ACID UNDER CHANGING ENVIRONMENT: A REVIEW
Qaiser Hayat (2010)
10.1007/BF02873173
The constituents ofCannabis sativa pollen
M. Paris (2008)
10.1073/pnas.1103010108
Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco
Petri Lackman (2011)
Common cannabinoid phenotypes in 350 stocks of Cannabis.
E. Small (1973)
10.1021/JA01062A046
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Y. Gaoni (1964)
Trichomes of Cannabis sativa as viewed with scanning electron microscope
M. Ledbetter (1975)
10.1016/j.jep.2012.01.051
Pharmacovigilance of herbal medicine.
D. Shaw (2012)
10.1016/J.CHEMOSPHERE.2004.10.009
The arbuscular mycorrhizal fungus Glomus mosseae induces growth and metal accumulation changes in Cannabis sativa L.
S. Citterio (2005)
10.1038/sj.bjp.0706415
Plant cannabinoids: a neglected pharmacological treasure trove
R. Mechoulam (2005)
10.1007/s10529-010-0225-9
Metabolic analysis of elicited cell suspension cultures of Cannabis sativa L. by 1H-NMR spectroscopy
J. Peč (2010)
10.1007/s002530000568
Effects of stress factors, bioregulators, and synthetic precursors on indole alkaloid production in compact callus clusters cultures of Catharanthus roseus
J. Zhao (2001)
10.1007/s00253-015-6660-8
Implications of endophyte-plant crosstalk in light of quorum responses for plant biotechnology
P. Kusari (2015)
10.1111/J.1469-185X.1986.TB00719.X
THE PHYTOALEXIN RESPONSE: ELICITATION, SIGNALLING AND CONTROL OF HOST GENE EXPRESSION
R. Dixon (1986)
10.3732/ajb.94.5.819
Elevated temperatures increase leaf senescence and root secondary metabolite concentrations in the understory herb Panax quinquefolius (Araliaceae).
Gerald Jochum (2007)
10.1016/j.tplants.2008.11.005
Jasmonate-inducible gene: What does it mean?
Laurens Pauwels (2009)
Antifungal Activity of the Volatiles of High Potency Cannabis sativa L. Against Cryptococcus neoformans
A. S. Wanas (2016)
10.1111/j.1556-4029.2011.02024.x
The Effect of Electrical Lighting Power and Irradiance on Indoor‐Grown Cannabis Potency and Yield
David J Potter (2012)
10.1016/j.brainresrev.2008.12.003
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
P. Anand (2009)
10.1016/J.ENVINT.2005.02.003
Chromium toxicity in plants.
A. Shanker (2005)
10.1016/j.tips.2009.07.006
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
A. Izzo (2009)
10.1146/ANNUREV.ARPLANT.52.1.29
ALKALOID BIOSYNTHESIS IN PLANTS: Biochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications.
P. Facchini (2001)
10.1038/346561A0
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
L. Matsuda (1990)
[Antibacterial action of Canabis indica].
Z. Krejčí (1952)
10.1111/J.1365-3040.1990.TB01304.X
Effects of metals on enzyme activity in plants
F. V. Assche (1990)
In vitro lethal efficacy of leaf extract of Cannabis sativa Linn on the larvae of Chironomous samoensis Edward: an insect of public health concern.
B. Roy (2003)
10.1073/pnas.0811861106
Phytohormone-based activity mapping of insect herbivore-produced elicitors
E. Schmelz (2009)
10.1038/1951007A0
Antibiotic Activity of Various Types of Cannabis Resin
A. Radošević (1962)
10.1371/journal.pone.0099641
Understanding Cultivar-Specificity and Soil Determinants of the Cannabis Microbiome
Max E Winston (2014)
10.17660/ACTAHORTIC.2002.576.19
Strategies and recent achievements in selection of medicinal and aromatic plants
J. Bernáth (2002)
10.1023/A:1015871916833
Biotechnology for the production of plant secondary metabolites
R. Verpoorte (2004)
10.1134/S1021443711030101
Effect of water deficit on biomass production and accumulation of secondary metabolites in roots of Glycyrrhiza uralensis
W. Li (2011)
10.1039/B211159B
Terrestrial ecosystems, increased solar ultraviolet radiation and interactions with other climatic change factors.
M. Caldwell (2003)
10.1007/s12298-008-0027-x
Photosynthetic response of Cannabis sativa L. to variations in photosynthetic photon flux densities, temperature and CO2 conditions
S. Chandra (2008)
10.1007/978-1-4419-1352-4_5
Heavy metals alter the potency of medicinal plants.
S. A. Nasim (2010)
10.1038/NCHEMBIO0707-360
Revisiting the ancient concept of botanical therapeutics.
B. Schmidt (2007)
10.1016/B978-0-12-395540-1.50011-7
CHAPTER 7 – Intrinsic and Extrinsic Factors Affecting the Production of Secondary Plant Products
H. Flück (1963)
10.1111/j.1476-5381.2011.01238.x
Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects
Ethan B. Russo (2011)
10.1021/jf204376j
Chitosan oligosaccharides promote the content of polyphenols in Greek oregano (Origanum vulgare ssp. hirtum).
H. Yin (2012)
10.1021/np900067k
Biologically active cannabinoids from high-potency Cannabis sativa.
M. Radwan (2009)
10.1111/J.1399-3054.2004.00332.X
Applied environmental stresses to enhance the levels of polyphenolics in leaves of hawthorn plants.
Ara Kirakosyan (2004)
10.1038/286056A0
Ovipositing butterfly (Pieris brassicae L.) distinguishes between aqueous extracts of two strains of Cannabis sativa L. and THC and CBD
M. Rothschild (1980)
10.1073/pnas.0803601105
Beta-caryophyllene is a dietary cannabinoid
J. Gertsch (2008)
10.1016/B978-0-12-800138-7.00005-X
Chapter Five – Elicitation: An Underutilized Tool in the Development of Medicinal Plants as a Source of Therapeutic Secondary Metabolites
Jonathan Gorelick (2014)
10.1001/jama.2015.6358
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
P. Whiting (2015)



This paper is referenced by
10.1007/978-3-030-23197-2
Controlled Environment Horticulture: Improving Quality of Vegetables and Medicinal Plants
Christoph-Martin Geilfus (2019)
10.1016/J.INDCROP.2018.06.033
Plant growth-promoting rhizobacteria (PGPR) in Cannabis sativa ‘Finola’ cultivation: An alternative fertilization strategy to improve plant growth and quality characteristics
Giancarlo Pagnani (2018)
10.1016/J.INDCROP.2018.11.039
Interplay between chemistry and morphology in medical cannabis (Cannabis sativa L.)
N. Bernstein (2019)
10.3390/microorganisms8030355
Cannabis Microbiome and the Role of Endophytes in Modulating the Production of Secondary Metabolites: An Overview
M. Taghinasab (2020)
10.3389/fpls.2019.00495
Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield
Rachel Backer (2019)
10.1002/pca.2915
Development of extraction technique and GC/FID method for the analysis of cannabinoids in Cannabis sativa L. spp. santicha (hemp).
J. Baranauskaite (2020)
10.1016/j.plaphy.2018.01.021
Piriformospora indica cell wall extract as the best elicitor for asiaticoside production in Centella asiatica (L.) Urban, evidenced by morphological, physiological and molecular analyses.
S. Jisha (2018)
10.3390/microorganisms9030518
Effect of Colonization of Trichoderma harzianum on Growth Development and CBD Content of Hemp (Cannabis sativa L.)
I. Kakabouki (2021)
10.3389/fpls.2020.00554
Cannabinomics: Application of Metabolomics in Cannabis (Cannabis sativa L.) Research and Development
K. A. Aliferis (2020)
10.1007/978-3-319-96397-6_41
Coevolution: Plant-Herbivore Interactions and Secondary Metabolites of Plants
Eunice Kariñho-Betancourt (2020)
10.3389/fpls.2019.00736
Impact of N, P, K, and Humic Acid Supplementation on the Chemical Profile of Medical Cannabis (Cannabis sativa L)
N. Bernstein (2019)
10.1016/BS.AGRON.2018.02.003
Antiinflammatory Potential of Medicinal Plants: A Source for Therapeutic Secondary Metabolites
N. Bernstein (2018)
10.1016/j.sajb.2019.10.015
Novel approaches towards over-production of andrographolide in in vitro seedling cultures of Andrographis paniculata
D. Das (2020)
Semantic Scholar Logo Some data provided by SemanticScholar