Chemical And Physical Elicitation For Enhanced Cannabinoid Production In Cannabis
Jonathan Gorelick, N. Bernstein
Published 2017 · Biology
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Of the many medicinal plants with therapeutic potential, Cannabis sativa is, by far, the most promising in the near future for large scale utilization. However, the inherent chemical variability of plant based medicines must be addressed, before cannabis can be incorporated into modern medical practices. This chemical variability can only be controlled and potentially optimized if the underlying causes of the production of therapeutic compounds in cannabis is adequately understood. Many of the medically useful compounds produced by plants are the result of the plant stress response. Although not completely clear, there is a significant body of evidence suggesting a similar role for cannabinoids. Cannabinoids are implicating in both, biotic and abiotic stresses, including thermal, nutrient, and water stress, photoradiation, as well as bacterial and fungal pathogens. This chapter will explore the possible ecological roles of cannabinoids in cannabis and the potential utilization of these roles via biotic or abiotic elicitors.
This paper references
Salicylic acid-independent plant defence pathways.
Cold acclimation induces distinctive changes in the chromatin state and transcript levels of COR genes in Cannabis sativa varieties with contrasting cold acclimation capacities.
Boris F. Mayer (2015)
Photosynthesis and cannabinoid content of temperate and tropical populations of Cannabis sativa
F. Bazzaz (1975)
An antibacterial preparatum from hemp (Cannabis sativa L.)
Lajos Ferenczy (2004)
Growth, metabolic profiling and enzymes activities of Catharanthus roseus seedlings treated with plant growth regulators
M. El-Sayed (2004)
Role of plant hormones in plant defence responses
R. Bari (2008)
Elicitation of pharmacologically active substances in an intact medical plant.
Stanislav Kužel (2009)
Elicitation studies in cell suspension cultures of Cannabis sativa L.
I. J. Flores-Sánchez (2009)
Effect of cultivars and deep freeze storage on saponin content of white asparagus spears (Asparagus officinalis L.)
Anita Schwarzbach (2005)
Influence of fertilization and drought stress on the growth and production of secondary metabolites in Prunella vulgaris L.
Yu-hang Chen (2011)
Effect of Elicitor Dosage and Exposure Time on Biosynthesis of Indole Alkaloids by Catharanthus roseus Hairy Root Cultures
S. K. Rijhwani (1998)
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
G. Appendino (2008)
Storage of cannabinoids by Arctia caja and Zonocerus elegans fed on chemically distinct strains of Cannabis sativa
M. Rothschild (1977)
Peripheral cannabinoid receptor, CB2, regulates bone mass.
O. Ofek (2006)
Constituents of Cannabis sativa L. XVII. A review of the natural constituents.
Carlton E. Turner (1980)
Endophytic fungi harbored in Cannabis sativa L.: diversity and potential as biocontrol agents against host plant-specific phytopathogens
P. Kusari (2012)
Influence of light on plant allelochemicals: A synergistic defense in higher plants
K. Downum (1991)
Possible role of ultraviolet radiation in evolution ofCannabis chemotypes
David W. Pate (2008)
The endocannabinoid system and its therapeutic exploitation
V. Marzo (2004)
Effect of metal toxicity on plant growth and metabolism: I. Zinc
G. R. Rout (2003)
Quorum quenching is an antivirulence strategy employed by endophytic bacteria
P. Kusari (2014)
Altitudinal Variation in Leaf Epidermal Patterns of Cannabis sativa
G. K. Sharma (1975)
Effect of the climate on the content of a CBD-rich variant of cannabis
Hafiz Hakim (1986)
Hypoglycemic activity of withanolides and elicitated Withania somnifera.
Jonathan Gorelick (2015)
Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis.
Gibberellins, jasmonate and abscisic acid modulate the sucrose-induced expression of anthocyanin biosynthetic genes in Arabidopsis.
E. Loreti (2008)
Herbal Medicine in Healthcare-An Overview
Mohammed Mosihuzzaman (2012)
Seasonal fluctuations in cannabinoid content of Kansas Marijuana
R. Latta (2008)
Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds.
H. N. Eisohly (1982)
Umbelliferone, a stress metabolite of Chamomilla recutita (L.) Rauschert
M. Repčák (2001)
DEFENSIVE RESIN BIOSYNTHESIS IN CONIFERS.
S. Trapp (2001)
Quantitative Changes of Secondary Metabolites of Matricaria chamomilla by Abiotic Stress
A. Eliášová (2004)
The multifaceted role of ABA in disease resistance.
J. Ton (2009)
Influence of environmental conditions on tetrahydrocannabinol (Delta ('9) TCH) in different cultivars on Cannabis sativa L.
G. Murari (1983)
Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John's wort.
S. M. A. Zobayed (2005)
Cannabis sativa L. growing on heavy metal contaminated soil: growth, cadmium uptake and photosynthesis
P. Linger (2005)
Study of Leaf Metabolome Modifications Induced by UV-C Radiations in Representative Vitis, Cissus and Cannabis Species by LC-MS Based Metabolomics and Antioxidant Assays
Guillaume Marti (2014)
Crosstalk between abiotic ultraviolet-B stress and biotic (flg22) stress signalling in Arabidopsis prevents flavonol accumulation in favor of pathogen defence compound production.
Dirk Schenke (2011)
From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis.
R. Mechoulam (1999)
Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex
F. Bambico (2007)
Induction of ajmalicine formation and related enzyme activities in Catharanthus roseus cells: effect of inoculum density
P. Moreno (2004)
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PHENYLPROPANOID METABOLISM
K. Hahlbrock (1989)
The chemistry of defense: theory and practice.
M. Berenbaum (1995)
Effects of ultraviolet-B radiation on cotton (Gossypium hirsutum L.) morphology and anatomy.
V. Kakani (2003)
Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation.
G. Cabral (2009)
Induction of phenylpropanoid and tyramine metabolism in pectinase- or pronase-elicited cell suspension cultures of tobacco (Nicotiana tabacum)
J. Negrel (1995)
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Y. Gaoni (1964)
The constituents ofCannabis sativa pollen
M. Paris (2008)
EFFECT OF EXOGENOUS SALICYLIC ACID UNDER CHANGING ENVIRONMENT: A REVIEW
Qaiser Hayat (2010)
Pharmacovigilance of herbal medicine.
D. Shaw (2012)
Common cannabinoid phenotypes in 350 stocks of Cannabis.
E. Small (1973)
Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco
Petri Lackman (2011)
Role of cannabinoid CB2 receptors in glucose homeostasis in rats.
F. Bermúdez-Silva (2007)
Stress-Induced Phenylpropanoid Metabolism.
R. Dixon (1995)
Impact of fertilization on drought response in the medicinal herb Bupleurum chinense DC.: Growth and saikosaponin production
Z. Zhu (2009)
Hemp diseases and pests. Management and biological control. An advanced treatise J.M. McPartland, R.C. Clarke and D.P. Watson; CABI Publishing Wallingford, Oxon, price £49.95 (US$90), ISBN 0-85199-454-7
D. Greathead (2001)
Plant defense against herbivores: chemical aspects.
A. Mithöfer (2012)
Abscisic acid interacts antagonistically with salicylic acid signaling pathway in rice-Magnaporthe grisea interaction.
Chang-Jie Jiang (2010)
Effects of ABA on primary terpenoids and Δ9-tetrahydrocannabinol in Cannabis sativa L. at flowering stage
Hakimeh Mansouri (2009)
Quantitative variation in the chemical constituents of marihuana from stands of naturalizedCannabis sativa L. in East-Central Illinois
Alan Haney (2008)
Plant secondary metabolism and challenges in modifying its operation: an overview.
N. C. D. Nascimento (2010)
Elicitation, a new window into plant chemodiversity and phytochemical drug discovery.
A. Poulev (2003)
Reduction of light-induced anthocyanin accumulation in inoculated sorghum mesocotyls. Implications for a compensatory role in the defense response.
S. C. Lo (1998)
The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida.
The Biochemistry and Molecular Biology of Isoprenoid Metabolism
J. Chappell (1995)
Effects of abscisic acid on content and biosynthesis of terpenoids in Cannabis sativa at vegetative stage
Hakimeh Mansouri (2012)
Effect of cadmium and nickel on photosynthesis and the enzymes of the photosynthetic carbon reduction cycle in pigeonpea (Cajanus cajan L.)
I. Sheoran (2004)
Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol
B. Klingeren (2004)
Pathogenicity of Phomopsis ganjae on Cannabis sativa and the fungistatic effect of cannabinoids produced by the host
J. Mcpartland (2004)
LCMS Spectral Evidence of the Occurrence of Cannabinoid in Cannabis sativa Cell Cultures
Sayed Farag (2013)
Jasmonates and related oxylipins in plant responses to pathogenesis and herbivory.
E. Farmer (2003)
Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects
A. Izzo (2008)
Effective Phytoextraction of Cadmium (Cd) with Increasing Concentration of Total Phenolics and Free Proline in Cannabis sativa (L) Plant Under Various Treatments of Fertilizers, Plant Growth Regulators and Sodium Salt
A. Ahmad (2015)
Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum.
J. Wu (2001)
Long-Term Effect of a Pythium Elicitor Treatment on the Growth and Alkaloid Production of Catharanthus roseus Cell Suspensions.
C. Nef-Campa (1994)
Antifungal Activity of the Volatiles of High Potency Cannabis sativa L. Against Cryptococcus neoformans
Amira Samir Wanas (2016)
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
A. Izzo (2009)
Jasmonate-inducible gene: What does it mean?
Laurens Pauwels (2009)
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
P. Anand (2009)
Elevated temperatures increase leaf senescence and root secondary metabolite concentrations in the understory herb Panax quinquefolius (Araliaceae).
Gera M Jochum (2007)
Chromium toxicity in plants.
A. Shanker (2005)
The effect of electrical lighting power and irradiance on indoor-grown cannabis potency and yield.
D. J. Potter (2012)
Implications of endophyte-plant crosstalk in light of quorum responses for plant biotechnology
Parijat Kusari (2015)
Metabolic analysis of elicited cell suspension cultures of Cannabis sativa L. by 1H-NMR spectroscopy
Jaroslav Peč (2010)
Plant cannabinoids: a neglected pharmacological treasure trove
R. Mechoulam (2005)
Effects of stress factors, bioregulators, and synthetic precursors on indole alkaloid production in compact callus clusters cultures of Catharanthus roseus
J. Zhao (2001)
THE PHYTOALEXIN RESPONSE: ELICITATION, SIGNALLING AND CONTROL OF HOST GENE EXPRESSION
R. Dixon (1986)
The arbuscular mycorrhizal fungus Glomus mosseae induces growth and metal accumulation changes in Cannabis sativa L.
S. Citterio (2005)
Photosynthetic response of Cannabis sativa L. to variations in photosynthetic photon flux densities, temperature and CO2 conditions
Suman Chandra (2008)
Biotechnology for the production of plant secondary metabolites
R. Verpoorte (2004)
Understanding Cultivar-Specificity and Soil Determinants of the Cannabis Microbiome
Max E Winston (2014)
Terrestrial ecosystems, increased solar ultraviolet radiation and interactions with other climatic change factors.
M. Caldwell (2003)
Effect of water deficit on biomass production and accumulation of secondary metabolites in roots of Glycyrrhiza uralensis
W. Li (2011)
Heavy metals alter the potency of medicinal plants.
S. A. Nasim (2010)
Strategies and recent achievements in selection of medicinal and aromatic plants
J. Bernáth (2002)
[Antibacterial action of Canabis indica].
Zdeněk Krejčí (1952)
In vitro lethal efficacy of leaf extract of Cannabis sativa Linn on the larvae of Chironomous samoensis Edward: an insect of public health concern.
B. Roy (2003)
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
L. Matsuda (1990)
Effects of metals on enzyme activity in plants.
F. V. Assche (1990)
ALKALOID BIOSYNTHESIS IN PLANTS: Biochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications.
P. Facchini (2001)
Phytohormone-based activity mapping of insect herbivore-produced elicitors
E. Schmelz (2009)
Antibiotic Activity of Various Types of Cannabis Resin
A. Radošević (1962)
CHAPTER 7 – Intrinsic and Extrinsic Factors Affecting the Production of Secondary Plant Products
H. Flück (1963)
Beta-caryophyllene is a dietary cannabinoid
J. Gertsch (2008)
Applied environmental stresses to enhance the levels of polyphenolics in leaves of hawthorn plants.
Ara Kirakosyan (2004)
Biologically active cannabinoids from high-potency Cannabis sativa.
M. Radwan (2009)
Chitosan oligosaccharides promote the content of polyphenols in Greek oregano (Origanum vulgare ssp. hirtum).
H. Yin (2012)
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
P. Whiting (2015)
Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects
Ethan B. Russo (2011)
Revisiting the ancient concept of botanical therapeutics.
B. Schmidt (2007)
Chapter Five – Elicitation: An Underutilized Tool in the Development of Medicinal Plants as a Source of Therapeutic Secondary Metabolites
Jonathan Gorelick (2014)
Ovipositing butterfly (Pieris brassicae L.) distinguishes between aqueous extracts of two strains of Cannabis sativa L. and THC and CBD
M. Rothschild (1980)
This paper is referenced by
Coevolution: Plant-Herbivore Interactions and Secondary Metabolites of Plants
Eunice Kariñho-Betancourt (2020)
Plant growth-promoting rhizobacteria (PGPR) in Cannabis sativa ‘Finola’ cultivation: An alternative fertilization strategy to improve plant growth and quality characteristics
Giancarlo Pagnani (2018)
Interplay between chemistry and morphology in medical cannabis (Cannabis sativa L.)
Nirit Bernstein (2019)
Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield
Rachel Backer (2019)
Piriformospora indica cell wall extract as the best elicitor for asiaticoside production in Centella asiatica (L.) Urban, evidenced by morphological, physiological and molecular analyses.
S. Jisha (2018)
Cannabinomics: Application of Metabolomics in Cannabis (Cannabis sativa L.) Research and Development
Konstantinos A. Aliferis (2020)
Cannabis Microbiome and the Role of Endophytes in Modulating the Production of Secondary Metabolites: An Overview
Meysam Taghinasab (2020)
Controlled Environment Horticulture: Improving Quality of Vegetables and Medicinal Plants
Christoph-Martin Geilfus (2019)
Development of extraction technique and GC/FID method for the analysis of cannabinoids in Cannabis sativa L. spp. santicha (hemp).
J. Baranauskaite (2020)
Antiinflammatory Potential of Medicinal Plants: A Source for Therapeutic Secondary Metabolites
Nirit Bernstein (2018)
Impact of N, P, K, and Humic Acid Supplementation on the Chemical Profile of Medical Cannabis (Cannabis sativa L)
N. Bernstein (2019)
Novel approaches towards over-production of andrographolide in in vitro seedling cultures of Andrographis paniculata
D. Das (2020)