Online citations, reference lists, and bibliographies.

The Elephant In The Room: The Role Of Microtubules In Cancer.

Luca Cirillo, M. Gotta, P. Meraldi
Published 2017 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour constitutes the basis for many biological processes such as cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked to chromosomal instability, aneuploidy and development of drug resistances. The elephant in the room, however, is that despite all these evidences, the exact role of microtubules in malignancies remains elusive, partially due to the lack of clear genetic alterations linking microtubules to cancer. This review will discuss the molecular mechanisms that might alter microtubule dynamics in cancer cells, the pro and cons of the different theories linking these alterations to cancer progression, and the possible directions to address future key questions.
This paper references
10.1158/1535-7163.MCT-09-0674
Human Mutations That Confer Paclitaxel Resistance
Shanghua Yin (2010)
10.1016/j.febslet.2013.08.032
Overexpression, purification, and functional analysis of recombinant human tubulin dimer
Itsushi Minoura (2013)
Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation.
L. Martello (2003)
10.1186/s13008-015-0009-7
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos
Maybelline Giam (2015)
Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.
M. Kavallaris (2001)
10.1016/j.cub.2015.06.021
Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway
Anna A Ye (2015)
10.1073/pnas.83.19.7162
Common and distinct tubulin binding sites for microtubule-associated proteins.
U. Littauer (1986)
10.1038/ncb1703
EB1 regulates microtubule dynamics and tubulin sheet closure in vitro
B. Vitre (2008)
10.1016/j.cca.2016.05.012
End Binding 1 (EB1) overexpression in oral lesions and cancer: A biomarker of tumor progression and poor prognosis.
M. Kumar (2016)
Embryonic expression of the divergent Drosophila beta3-tubulin isoform is required for larval behavior.
R. Dettman (2001)
10.1016/0955-0674(95)80047-6
Microtubules and microtubule-associated proteins.
E. Mandelkow (1995)
10.1038/nrm3494
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
Emily A Foley (2012)
10.4161/cbt.3.11.1216
Cell cycle effects and induction of premitotic apoptosis by irofulven in synchronized cancer cells
J. Woynarowski (2004)
10.1038/sj.onc.1206934
Mechanisms of Taxol resistance related to microtubules
G. Orr (2003)
10.1016/j.cell.2007.11.043
XMAP215 Is a Processive Microtubule Polymerase
G. Brouhard (2008)
10.1002/(SICI)1097-0169(1998)39:4<273::AID-CM3>3.0.CO;2-4
Preparation of a monoclonal antibody specific for the class I isotype of beta-tubulin: the beta isotypes of tubulin differ in their cellular distributions within human tissues.
Mary Carmen Roach (1998)
10.1007/978-1-59745-336-3_6
The Isotypes of Tubulin
R. Luduena (2008)
10.1093/JNCI/94.18.1358
Cancer Incidence in BRCA1 mutation carriers.
D. Thompson (2002)
10.1893/0005-3155-84.3.136
Overexpression of the kinetochore-associated proteins SKAP and astrin in human breast cancer
C. Wright (2013)
10.1091/mbc.E11-12-1013
Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation
Emily A. Hood (2012)
10.1242/jcs.091967
Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation
N. Mchedlishvili (2012)
10.1016/j.lungcan.2008.07.016
Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients.
C. Choi (2009)
10.1111/j.1432-1033.1995.406_b.x
Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors.
S. Charrasse (1995)
10.1002/ijc.27924
Cancer cells preferentially lose small chromosomes
P. H. Duijf (2013)
10.1038/emboj.2010.230
CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore‐microtubule dynamics to promote mitotic progression and fidelity
A. Manning (2010)
10.1091/MBC.E07-06-0537
The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation.
N. Pathak (2007)
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
A. Mialhe (2001)
10.1007/BF01882039
Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung
D. D. Hansemann (2005)
10.1091/mbc.E12-06-0444
One-step purification of assembly-competent tubulin from diverse eukaryotic sources
Per O. Widlund (2012)
10.1083/jcb.100.1.276
Purification of brain tubulin-tyrosine ligase by biochemical and immunological methods
H. Schröder (1985)
10.1083/jcb.201406055
The tubulin code: Molecular components, readout mechanisms, and functions
C. Janke (2014)
10.1038/35094067
APC, Signal transduction and genetic instability in colorectal cancer
R. Fodde (2001)
Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer.
T. Kuukasjärvi (1997)
10.1242/bio.201410843
TACC3–ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Cristina Gutiérrez-Caballero (2015)
10.1126/SCIENCE.1113010
Tubulin Polyglutamylase Enzymes Are Members of the TTL Domain Protein Family
C. Janke (2005)
10.1038/ncb2920
Regulation of microtubule motors by tubulin isotypes and posttranslational modifications
M. Sirajuddin (2014)
10.1074/JBC.M011380200
Differential Binding Regulation of Microtubule-associated Proteins MAP1A, MAP1B, and MAP2 by Tubulin Polyglutamylation*
C. Bonnet (2001)
10.1002/ijc.20431
Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis
C. Kato (2004)
10.1091/MBC.E06-10-0963
Chromosome malorientations after meiosis II arrest cause nondisjunction.
Marie A. Janicke (2007)
10.1016/j.cub.2006.09.014
Microtubule Acetylation Promotes Kinesin-1 Binding and Transport
N. Reed (2006)
10.1038/ncb1160
EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration
Ying Wen (2004)
10.1007/s10822-014-9756-9
Molecular insight of isotypes specific β-tubulin interaction of tubulin heterodimer with noscapinoids
S. Santoshi (2014)
10.7150/thno.9727
Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis
Tala (2014)
10.1002/mc.20627
Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma.
Sen-Yung Hsieh (2010)
10.1083/jcb.200905057
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
Sarah L. Thompson (2010)
10.3390/biology6010001
Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments
M. Lampson (2017)
Conservation of the Class I -Tubulin Gene in Human Populations and Lack of Mutations in Lung Cancers and Paclitaxel-resistant Ovarian Cancers 1
S. Šale (2002)
10.1073/pnas.1002128107
Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry
K. Ikegami (2010)
10.1083/jcb.120.3.725
Characterization of the tubulin-tyrosine ligase
K. Ersfeld (1993)
10.1038/nrneurol.2015.225
Tau and neurodegenerative disease: the story so far
K. Iqbal (2016)
10.1002/pmic.200800155
Proteomic identification of molecular targets of gambogic acid: role of stathmin in hepatocellular carcinoma.
X. Wang (2009)
10.1016/j.cub.2015.05.013
Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I
Lukas Chmatal (2015)
10.1016/S0960-9822(01)00002-1
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation
J. Zumbrunn (2001)
10.1042/BST0381704
Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability.
Ailine Stolz (2010)
10.1002/PMIC.200401307
Proteomic identification of differentially-expressed genes in human gastric carcinomas.
R. Nishigaki (2005)
10.1016/j.febslet.2014.01.046
End‐binding protein 1 (EB1) up‐regulation is an early event in colorectal carcinogenesis
Y. Stypula-Cyrus (2014)
10.1002/ijc.25916
Kinesin 18A expression: Clinical relevance to colorectal cancer progression
M. Nagahara (2011)
A monoclonal antibody against the type II isotype of beta-tubulin. Preparation of isotypically altered tubulin.
A. Banerjee (1988)
10.1083/jcb.200712029
Examining the link between chromosomal instability and aneuploidy in human cells
Sarah L. Thompson (2008)
10.1172/JCI119642
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.
M. Kavallaris (1997)
10.1016/S0002-9440(10)62493-5
Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma.
Mohammad H Soltani (2005)
10.1007/s10120-003-0235-6
Absence of beta-tubulin gene mutation in gastric carcinoma
N. Urano (2003)
10.1016/S0006-291X(75)80497-9
An enzyme tyrosylating α-tubulin and its role in microtubule assembly
D. Raybin (1975)
10.1023/A:1022946305242
Different Effects of Vinblastine on the Polymerization of Isotypically Purified Tubulins from Bovine Brain
I. Khan (2004)
10.1038/ng1449
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
S. Hanks (2004)
10.1083/JCB.153.3.517
Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells
D. Cimini (2001)
10.1091/mbc.E11-02-0095
Timing of centrosome separation is important for accurate chromosome segregation
William T. Silkworth (2012)
10.1126/science.1167000
Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates
Dan Liu (2009)
10.1515/hsz-2013-0184
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division
Harish C. Thakur (2013)
10.1016/S1534-5807(04)00025-5
Aurora B regulates MCAK at the mitotic centromere.
P. D. Andrews (2004)
10.1371/journal.pone.0156048
Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations
Bajarang Vasant Kumbhar (2016)
10.1083/jcb.131.3.721
Kinetochore microtubule dynamics and the metaphase-anaphase transition
Y. Zhai (1995)
10.1016/j.cub.2015.08.051
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
A. Musacchio (2015)
10.1002/DDR.10023
Interaction of nocodazole with tubulin isotypes
Keliang Xu (2002)
10.1016/j.cub.2010.01.034
Mechanisms of Chromosomal Instability
Sarah L. Thompson (2010)
10.1038/bjc.2014.427
The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer
T. Hemdan (2014)
10.1002/ijc.10575
Mutational analysis of the class I β‐tubulin gene in human breast cancer
S. Hasegawa (2002)
10.1073/pnas.1525129113
CHK2–BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly
N. Ertych (2016)
10.1186/1471-2407-8-106
Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis
S. Blenk (2007)
10.1002/cm.970120408
Differential localisation of tyrosinated, detyrosinated, and acetylated alpha-tubulins in neurites and growth cones of dorsal root ganglion neurons.
S. J. Robson (1989)
10.1038/nrc2251
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
L. Antoni (2007)
10.1371/journal.pone.0013553
Mutation of Ser172 in Yeast β Tubulin Induces Defects in Microtubule Dynamics and Cell Division
Fabrice Caudron (2010)
Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms.
F. Mertens (1997)
10.1038/ncb899
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
A. Hergovich (2003)
10.1007/s10620-013-2692-z
Increased α-Tubulin1b Expression Indicates Poor Prognosis and Resistance to Chemotherapy in Hepatocellular Carcinoma
Cuihua Lu (2013)
10.1006/BBRC.2000.2246
Markedly Decreased Binding of Vincristine to Tubulin in Vinca Alkaloid-Resistant Chinese Hamster Cells Is Associated with Selective Overexpression of α and β Tubulin Isoforms
F. Sirotnak (2000)
10.1158/1078-0432.CCR-08-1274
Overexpression of Class III β-Tubulin Predicts Good Response to Taxane-Based Chemotherapy in Ovarian Clear Cell Adenocarcinoma
D. Aoki (2009)
10.1083/jcb.200805072
Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied
Daniela A. Brito (2008)
10.1111/j.1349-7006.1998.tb00654.x
Preferential Binding of E7010 to Murine β3‐Tubulin and Decreased β3‐Tubulin in E7010‐resistant Cell Lines
Y. Iwamoto (1998)
10.1038/35070123
A role for the Adenomatous Polyposis Coli protein in chromosome segregation
K. Kaplan (2001)
10.1002/cm.20274
The roles of cys124 and ser239 in the functional properties of human betaIII tubulin.
Patrick A. Joe (2008)
10.1158/0008-5472.CAN-10-3604
Chromosomal instability confers intrinsic multidrug resistance.
A. J. Lee (2011)
10.3109/10715761003667554
Reactive oxygen species in cancer
Geou-Yarh Liou (2010)
10.1091/MBC.E05-08-0723
Survivin modulates microtubule dynamics and nucleation throughout the cell cycle.
Jack Rosa (2006)
10.1038/sj.bjc.6603905
Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer
Y. Nakamura (2007)
10.1016/j.cub.2004.01.055
Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity
Weijie Lan (2004)
10.1038/nature12507
Cyclin A Regulates Kinetochore-Microtubules to Promote Faithful Chromosome Segregation
Lilian Kabeche (2013)
10.1073/pnas.1109720108
Chromosome missegregation in human cells arises through specific types of kinetochore–microtubule attachment errors
Sarah L. Thompson (2011)
10.1002/CM.10132
Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel.
Malathi Hari (2003)
10.1371/journal.pone.0051258
Tubulin Tyrosine Ligase Like 12, a TTLL Family Member with SET- and TTL-Like Domains and Roles in Histone and Tubulin Modifications and Mitosis
Jan R Brants (2012)
10.1091/MBC.E05-07-0621
Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.
A. Fourest-Lieuvin (2006)
10.1101/GAD.934801
The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.
S. Biggins (2001)
10.1016/j.devcel.2016.10.023
Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.
L. Funk (2016)
10.1242/jcs.075911
Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment
Wenxiang Fu (2010)
10.1038/onc.2015.290
The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability
S. Lüddecke (2016)
10.3389/fonc.2014.00153
Microtubules and Their Role in Cellular Stress in Cancer
Amelia L. Parker (2014)
10.1158/1078-0432.CCR-04-0455
HDAC6 Expression Is Correlated with Better Survival in Breast Cancer
Z. Zhang (2004)
10.1111/j.1582-4934.2009.00905.x
Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group
C. Heilig (2010)
10.1074/jbc.M111.296483
Mitotic Centromere-associated Kinesin (MCAK) Mediates Paclitaxel Resistance*
Anutosh Ganguly (2011)
10.1073/pnas.1016498108
XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region
Per O. Widlund (2011)
10.1038/nrm2718
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
A. Holland (2009)
Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells.
D. Cimini (2002)
10.1021/bi00439a040
Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.
R. Bai (1989)
10.1016/0006-291X(76)90841-X
The distribution of tyrosyltubulin ligase in brain and other tissues.
Grace G. Deanin (1976)
10.1083/jcb.200906147
Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation
J. V. van Ree (2010)
10.1083/jcb.201006044
KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC
F. Jaulin (2010)
10.1002/j.1460-2075.1992.tb05269.x
Restin: a novel intermediate filament‐associated protein highly expressed in the Reed‐Sternberg cells of Hodgkin's disease.
G. Bilbe (1992)
10.1073/pnas.0700631104
Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations
C. Gao (2007)
10.1054/bjoc.2001.1956
Modulation of endogenous β-tubulin isotype expression as a result of human βIII cDNA transfection into prostate carcinoma cells
S. Ranganathan (2001)
10.1186/gb-2004-6-1-204
The MAP2/Tau family of microtubule-associated proteins
L. Dehmelt (2004)
10.1242/jcs.047944
Aneuploidy in mitosis of PtK1 cells is generated by random loss and nondisjunction of individual chromosomes
L. Torosantucci (2009)
10.3892/IJMM.20.4.605
The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells.
Mohammad K Zia (2007)
10.1158/1541-7786.MCR-06-0208
Roles of Aurora Kinases in Mitosis and Tumorigenesis
J. Fu (2007)
10.1016/j.cellsig.2008.12.004
Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53.
Julien Giustiniani (2009)
Regulation of microtubule stability and mitotic progression by survivin.
A. Giodini (2002)
10.1016/J.CEB.2006.10.002
Does aneuploidy cause cancer?
Beth A. A. Weaver (2006)
10.1002/ajmg.a.32315
Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: Delineation of clinical subtypes
H. García-Castillo (2008)
10.3389/fonc.2015.00225
The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling
V. Krenn (2015)
10.1038/embor.2012.65
Chromosomal instability and aneuploidy in cancer: from yeast to man
S. Pfau (2012)
10.1128/EC.00176-09
Hyperglutamylation of Tubulin Can either Stabilize or Destabilize Microtubules in the Same Cell
D. Wloga (2009)
10.1016/j.bcp.2011.12.034
Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53.
Tzu-Ching Kuo (2012)
10.1021/bi951247p
Phosphorylation of III -Tubulin
Israr Ahmad Khan (1996)
10.1093/carcin/bgq134
Kif18A is involved in human breast carcinogenesis.
C. Zhang (2010)
10.1038/onc.2012.576
Genetic instability: tipping the balance
A. Janssen (2013)
10.1016/0014-5793(77)80968-X
Release of tyrosine from tyrosinated tubulin. Some common factors that affect this process and the assembly of tubulin
M. Hallak (1977)
10.1083/jcb.201006129
Aurora B kinase controls the targeting of the Astrin–SKAP complex to bioriented kinetochores
J. Schmidt (2010)
10.1016/j.cub.2006.07.022
Aurora Kinase Promotes Turnover of Kinetochore Microtubules to Reduce Chromosome Segregation Errors
D. Cimini (2006)
10.1016/j.tcb.2011.01.003
Merotelic kinetochore attachment: causes and effects
J. Gregan (2011)
10.1002/hep.22552
Proteomic profiling reveals the prognostic value of adenomatous polyposis coli–end‐binding protein 1 in hepatocellular carcinoma
Tatsuya Orimo (2008)
10.1158/0008-5472.CAN-13-3563
α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration.
A. Boggs (2015)
10.1016/S0959-8049(02)00040-0
The APC gene in colorectal cancer.
R. Fodde (2002)
10.1007/s13238-013-3007-z
Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170
X. Sun (2013)
Suppression of tubulin tyrosine ligase during tumor growth.
L. Lafanechère (1998)
Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies.
L. Paturle-Lafanechère (1994)
10.1091/mbc.E08-02-0198
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.
X. Zhang (2008)
10.1038/386623a0
Genetic instability in colorectal cancers
C. Lengauer (1997)
10.1038/ncb1809
Genome stability is ensured by temporal control of kinetochore-microtubule dynamics
S. Bakhoum (2009)
10.1038/nrm3916
Regulation of kinetochore–microtubule attachments through homeostatic control during mitosis
K. Godek (2015)
10.1186/1476-4598-10-131
Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces
I. A. Asteriti (2011)
10.1002/pros.21444
Serum-autoantibodies for discovery of prostate cancer specific biomarkers.
P. Massoner (2012)
10.1038/sj.bjc.6690507
Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol
M. Kavallaris (1999)
10.1111/j.1432-1033.1975.tb02435.x
Incorporation of L-tyrosine, L-phenylalanine and L-3,4-dihydroxyphenylalanine as single units into rat brain tubulin.
C. Arce (1975)
10.4161/cc.8.20.9690
Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy
S. E. McClelland (2009)
10.1002/9780470015902.A0022413
Chromosome Instability (CIN), Aneuploidy and Cancer
Karen Wing Yee Yuen (2010)
10.1016/S0092-8674(00)81037-5
Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules
L. Belmont (1996)
10.1083/jcb.201211127
Coordination of adjacent domains mediates TACC3–ch-TOG–clathrin assembly and mitotic spindle binding
Fiona E. Hood (2013)
10.1083/jcb.200911120
Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability
Chiou-Hong Lin (2010)
10.1016/S0006-2952(97)00472-3
Association of estramustine resistance in human prostatic carcinoma cells with modified patterns of tubulin expression.
S. Sangrajrang (1998)
10.1083/jcb.201205090
Polo-like kinase-1 regulates kinetochore–microtubule dynamics and spindle checkpoint silencing
Dan Liu (2012)
10.1083/jcb.200208058
Cytoplasmic linker proteins promote microtubule rescue in vivo
Y. Komarova (2002)
10.1111/j.1349-7006.2007.00635.x
Involvement of kinesin family member 2C/mitotic centromere‐associated kinesin overexpression in mammary carcinogenesis
A. Shimo (2008)
10.1155/2011/615912
Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I
S. Morimura (2011)
10.1038/emboj.2011.15
A TACC3/ch‐TOG/clathrin complex stabilises kinetochore fibres by inter‐microtubule bridging
Daniel G Booth (2011)
10.1083/jcb.200706015
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
K. Jeganathan (2007)
10.1016/S1535-6108(03)00110-7
Chk1 and Chk2 kinases in checkpoint control and cancer.
J. Bartek (2003)
10.1073/pnas.0803504105
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
E. Díaz-Rodríguez (2008)
10.1073/pnas.1504081112
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
Harindranath Kadavath (2015)
10.1242/bio.2011012
Dual pathway spindle assembly increases both the speed and the fidelity of mitosis
K. Kaseda (2011)
10.1182/blood-2009-11-251074
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
J. den Hollander (2010)
10.1002/cncr.23248
Histopathologic determinants of regional lymph node metastasis in early colorectal cancer
Y. Ishikawa (2008)
10.1016/j.ceb.2016.02.016
Attachment issues: kinetochore transformations and spindle checkpoint silencing.
B. Etemad (2016)
10.1038/ncomms12619
Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
W. Zhang (2016)
10.1091/MBC.E04-12-1106
Interactions between CLIP-170, tubulin, and microtubules: implications for the mechanism of Clip-170 plus-end tracking behavior.
Eric S. Folker (2005)
10.1038/35053094
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
L. Michel (2001)
10.1038/sj.onc.1207113
Survivin, versatile modulation of cell division and apoptosis in cancer
D. Altieri (2003)
10.1371/journal.pone.0012564
Cancer Cells Acquire Mitotic Drug Resistance Properties Through Beta I-Tubulin Mutations and Alterations in the Expression of Beta-Tubulin Isotypes
C. H. Cheung (2010)
10.1038/emboj.2010.294
Kinetochore–microtubule interactions: steps towards bi‐orientation
T. Tanaka (2010)
10.1016/j.cub.2012.02.030
Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells
Lilian Kabeche (2012)
10.1177/1947601913479022
Cyclins and cell cycle control in cancer and disease.
M. Casimiro (2012)
10.1016/j.molcel.2010.02.034
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.
J. P. Welburn (2010)
10.1038/312237a0
Dynamic instability of microtubule growth
T. Mitchison (1984)
Neuronal-associated microtubule proteins class III beta-tubulin and MAP2c in neuroblastoma: role in resistance to microtubule-targeted drugs.
Sima Don (2004)
10.1083/jcb.104.6.1569
Posttranslational modifications of alpha-tubulin: acetylated and detyrosinated forms in axons of rat cerebellum
M. Cambray-Deakin (1987)
10.1038/nature06344
The centromere geometry essential for keeping mitosis error free is controlled by spindle forces
J. Loncarek (2007)
10.1186/1471-2407-5-101
No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin
B. Mesquita (2005)
10.1038/ncb1102
Correcting improper chromosome–spindle attachments during cell division
M. Lampson (2004)
10.1242/jcs.094607
The role of clathrin in mitotic spindle organisation
S. Royle (2012)
10.1091/mbc.E14-03-0837
Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program
P. Thiru (2014)
10.1016/J.CCR.2006.12.003
Aneuploidy acts both oncogenically and as a tumor suppressor.
Beth A. A. Weaver (2007)
10.1038/nrc3844
VHL, the story of a tumour suppressor gene
L. Gossage (2014)
10.1002/path.2662
Oncogenic function of microtubule end-binding protein 1 in breast cancer.
X. Dong (2010)
10.1002/path.3026
Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity.
X. Sun (2012)
10.1038/bjc.1998.91
Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells.
S. Ranganathan (1998)
10.1083/jcb.200707120
MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover
L. Wordeman (2007)
10.1073/PNAS.0408974102
Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer.
R. Rouzier (2005)
10.1038/ncb2994
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells
N. Ertych (2014)
10.1016/S0092-8674(02)00633-5
Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections
T. Tanaka (2002)
10.1021/BI027293O
Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry.
P. Verdier-Pinard (2003)
10.1158/1078-0432.CCR-05-0285
Expression of Class III β-Tubulin Is Predictive of Patient Outcome in Patients with Non–Small Cell Lung Cancer Receiving Vinorelbine-Based Chemotherapy
P. Sève (2005)
10.1016/S0304-3835(03)00279-9
Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer.
K. Maeno (2003)
10.1038/nrc2964
Shared and separate functions of polo-like kinases and aurora kinases in cancer
S. Lens (2010)
10.1158/2159-8290.CD-14-0403
DNA-damage response during mitosis induces whole-chromosome missegregation.
S. Bakhoum (2014)
10.1002/ijc.25261
Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy
C. Wasylyk (2010)
10.1038/25292
Genetic instabilities in human cancers
C. Lengauer (1998)
10.1242/jcs.013136
Aurora-A: the maker and breaker of spindle poles
A. Barr (2007)
Composite microtubules of the axon: quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules.
A. Brown (1993)
10.1038/nrc2781
Mitotic chromosomal instability and cancer: mouse modelling of the human disease
Juan-Manuel Schvartzman (2010)
10.1038/nature10802
DNA breaks and chromosome pulverization from errors in mitosis
Karen Crasta (2012)
10.1128/MCB.19.3.1720
Correlation between Protein and mRNA Abundance in Yeast
S. Gygi (1999)
10.3233/CBM-130296
Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma.
R. Rucksaken (2012)
10.1016/S0960-9822(02)00887-4
Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis
M. Kallio (2002)
10.1158/1535-7163.MCT-10-1109
Overexpression of Mitotic Centromere–Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel
Anutosh Ganguly (2011)
10.1074/jbc.270.52.31269
Altered Expression of M2, the Class II -Tubulin Isotype, in a Murine J774.2 Cell Line with a High Level of Taxol Resistance (*)
M. Haber (1995)
10.1158/1078-0432.CCR-05-0903
Increased Expression of Mitotic Checkpoint Genes in Breast Cancer Cells with Chromosomal Instability
Bibo Yuan (2006)
10.1371/journal.pone.0114511
Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma
Boban Stanojević (2014)
Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients.
S. Mozzetti (2005)
10.1523/JNEUROSCI.0037-07.2007
Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation
J. Dompierre (2007)
10.1083/jcb.200208091
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
Claire Ditchfield (2003)
10.1016/j.tcb.2010.10.007
Sensing centromere tension: Aurora B and the regulation of kinetochore function.
M. Lampson (2011)
10.1016/J.GDE.2006.12.008
Cell cycle kinases in cancer.
M. Malumbres (2007)
10.1016/j.devcel.2016.12.022
Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.
Michelle S. Levine (2017)
10.18632/ONCOTARGET.2946
βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer
J. McCarroll (2015)
10.1038/sj.onc.1202247
EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle
E. Morrison (1998)
10.1083/jcb.201108147
MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment
Sarah Domnitz (2012)
10.1126/science.1160058
Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells
B. R. Williams (2008)
10.1186/1476-4598-12-4
Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells
Charlotte M. Smith (2012)
10.1083/jcb.200208092
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
S. Hauf (2003)
10.1083/jcb.200503023
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis
K. Kinoshita (2005)
10.3390/biology5040055
A Brief History of Research on Mitotic Mechanisms
J Richard McIntosh (2016)
10.1091/MBC.12.4.971
Cell Cycle-Dependent Changes in Microtubule Dynamics in Living Cells Expressing Green Fluorescent Protein-α Tubulin
Nm Rusan (2001)
10.1016/S0006-291X(02)00269-3
Increased levels of tyrosinated α-, βIII-, and βIV-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells
A. Banerjee (2002)
10.4137/CIN.S8104
Mathematical Prognostic Biomarker Models for Treatment Response and Survival in Epithelial Ovarian Cancer
J. Nikas (2011)
10.1016/J.GDE.2007.02.011
Tetraploidy, aneuploidy and cancer.
Neil J Ganem (2007)
10.1016/j.ccell.2016.12.004
Single-chromosome Gains Commonly Function as Tumor Suppressors.
Jason M. Sheltzer (2017)
10.2174/092986711794480203
Aurora B: a new prognostic marker and therapeutic target in cancer.
G. Portella (2011)
10.1038/embor.2012.55
Losing balance: the origin and impact of aneuploidy in cancer
A. J. Holland (2012)
10.1093/JNCI/93.24.1886
Genetic Analysis of the β-Tubulin Gene, TUBB, in Non-Small-Cell Lung Cancer
M. Kelley (2001)
10.1021/pr100712t
Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer.
P. Zheng (2010)
10.1016/j.cub.2009.09.055
Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability
S. Bakhoum (2009)
10.1091/MBC.E02-04-0210
EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules.
J. Tirnauer (2002)
10.1126/science.aaa5175
Microtubule detyrosination guides chromosomes during mitosis
Marin Barisic (2015)
Preparation of a monoclonal antibody specific for the class IV isotype of beta-tubulin. Purification and assembly of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers from bovine brain.
A. Banerjee (1992)
10.1083/jcb.144.1.99
Dynamic Localization of CLIP-170 to Microtubule Plus Ends Is Coupled to Microtubule Assembly
G. S. Diamantopoulos (1999)
10.4161/cc.10.22.18106
Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability
Xiaoou Sun (2011)
Increase of βIII- and βIVa-Tubulin Isotypes in Human Prostate Carcinoma Cells as a Result of Estramustine Resistance
S. Ranganathan (1996)
10.1126/SCIENCE.1142210
Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
E. Torres (2007)
10.1158/0008-5472.CAN-09-4319
Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.
Saskia J E Suijkerbuijk (2010)
10.1021/BI0350147
Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry.
P. Verdier-Pinard (2003)
10.1007/s13277-013-1345-3
Overexpression of stathmin 1 confers an independent prognostic indicator in nasopharyngeal carcinoma
Han-Ping Hsu (2013)
10.1002/j.1460-2075.1988.tb03074.x
Differential distribution of beta‐tubulin isotypes in cerebellum.
R. Burgoyne (1988)
10.3109/10428199309059567
Restin in Hodgkin's disease and anaplastic large cell lymphoma.
J. Delabie (1993)
10.1111/j.1471-4159.1980.tb04628.x
Tubulinyl‐tyrosine Carboxypeptidase from Chicken Brain: Properties and Partial Purification
C. Argaraña (1980)
10.1083/jcb.201012035
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
Robin M. Ricke (2011)
10.1002/cm.20455
The β isotypes of tubulin in neuronal differentiation
Jiayan Guo (2010)
10.1038/ncb3060
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces
Marin Barisic (2014)
10.1016/j.semcdb.2014.09.026
Intrinsically disordered tubulin tails: complex tuners of microtubule functions?
A. Roll-Mecak (2015)
10.1016/J.CCR.2006.10.019
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.
R. Sotillo (2007)
beta tubulin mutations are rare in human ovarian carcinoma.
D. E. Lamendola (2003)
10.1093/ANNONC/MDM224
The role of Aurora-A inhibitors in cancer therapy.
V. Agnese (2007)
10.1016/j.cell.2015.07.012
Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins
R. Zhang (2015)
10.1016/j.cub.2006.11.071
Mechanisms of Spindle-Pole Organization Are Influenced by Kinetochore Activity in Mammalian Cells
A. Manning (2007)
10.1016/S0074-7696(08)62138-5
Multiple forms of tubulin: different gene products and covalent modifications.
R. Luduena (1997)
10.1016/0092-8674(86)90318-1
Beyond self-assembly: From microtubules to morphogenesis
M. Kirschner (1986)
10.1073/pnas.91.24.11358
Microtubule dynamics in vitro are regulated by the tubulin isotype composition.
D. Panda (1994)
10.1091/mbc.E13-07-0387
Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure
Stuart C Howes (2014)
10.1242/jcs.03485
Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene
K. Aoki (2007)
10.1083/jcb.200902142
Motor-dependent microtubule disassembly driven by tubulin tyrosination
L. Peris (2009)
10.1038/ng.822
Mutations in CEP57 cause mosaic variegated aneuploidy syndrome
K. Snape (2011)
10.3816/CBC.2002.N.037
Microtubule-associated parameters as predictive markers of docetaxel activity in advanced breast cancer patients: results of a pilot study.
C. Bernard-Marty (2002)
10.1111/jcmm.12216
FOXM1 mediates resistance to docetaxel in gastric cancer via up-regulating Stathmin
X. Li (2014)



This paper is referenced by
10.1016/j.bbamcr.2020.118673
During mitosis ZEB1 switches from being a chromatin-bound epithelial gene repressor, to become a microtubule-associated protein.
Leyla Fouani (2020)
10.1007/s00401-019-02067-z
FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas
Frank Brand (2019)
10.3390/ijms21051656
Beta3-Tubulin Is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375)
M. O. Altonsy (2020)
10.1111/ele.12833
Native insect herbivory overwhelms context dependence to limit complex invasion dynamics of exotic weeds.
Emily L. Schultz (2017)
10.32474/oajom.2018.02.000133
Permissiveness Paradox in Cell Cycle ProgressionTowards Genome Instability and MalignantTransformation
Lawrence M. Agius (2018)
10.1016/j.devcel.2018.04.009
Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages.
J. Chen (2018)
10.1016/j.bioorg.2020.103695
Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site.
Xi Hu (2020)
10.1002/prp2.616
Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy
Esther Forkosh (2020)
10.1080/13543784.2018.1471132
Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy
A. Schcolnik-Cabrera (2018)
10.1186/s13008-019-0046-8
A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin
Gianandrea Traversi (2019)
10.1007/978-981-13-8719-7_13
Allosteric Modulators of Protein-Protein Interactions (PPIs).
Duan Ni (2019)
10.1007/s00204-020-02784-5
Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens
M. Jacobs (2020)
10.3389/fmicb.2020.01908
Alphaherpesvirus Major Tegument Protein VP22: Its Precise Function in the Viral Life Cycle
Liping Wu (2020)
10.1002/jcp.27978
Microtubules: From understanding their dynamics to using them as potential therapeutic targets
Y. Ilan (2019)
10.1002/med.21585
Emerging roles of allosteric modulators in the regulation of protein-protein interactions (PPIs): A new paradigm for PPI drug discovery.
Duan Ni (2019)
Atypical Cadherin Dachsous 1 b Interacts with Ttc 28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages Highlights
J. Chen (2018)
Semantic Scholar Logo Some data provided by SemanticScholar