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Synthesis And Characterisation Of Magnetic Nanoparticles In Medicine
A. Majid, W. Ahmed, Yogita Patil-Sen, Tapas Sen
Published 2018 · Materials Science
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The idea of using magnetic nanomaterials in biomedical applications has been studied since last decades. Magnetic nanomaterials have been found as a promising candidate in biological applications. This chapter presented the diverse approach to engineer the nanoparticles for targeted applications. Superparamagnetic iron oxide nanoparticle (SPION) cores of 10–25 nm were synthesised using co-precipitation method iron (II) and iron (III) salts in alkaline medium. The superparamagnetic behaviour is an ideal solid support for the hyperthermia ablation and magnetic field-triggered stimuli for drug release. These cores were further coated with mesoporous silica rendering them versatile materials, which can enhance the stability, drug-loading capacity and its release in controllable manner. Moreover, their promising applications as magnetic field-triggered hyperthermia ablation and magnetic field-triggered controlled-release drug delivery combining both thermos-chemotherapy system.
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