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Biomimetic Adhesive Polymers Based On Mussel Adhesive Proteins
B. P. Lee, J. Dalsin, P. Messersmith
Published 2006 · Engineering
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Nature provides many outstanding examples of adhesive strategies from which chemists and material scientists can draw inspiration in their pursuit of new adhesive materials. As described in other chapters of this book, detailed studies of the adhesive mechanisms of geckos, mussels and other organisms during the past several decades have enhanced our understanding of the underlying physicochemical principles to the extent that direct translation of this knowledge into biomimetic strategies for synthesizing new practical adhesives is now possible. Although new biomimetic adhesives have the potential for impact in many areas of technology, one of the more compelling outlets for these materials is in healthcare delivery, which will be the focus of this chapter. Obvious parallels exist between the marine and human physiologic environment, and a strategy that works well in one context may be useful in the other. Efforts to develop biomimetic adhesives are most effective when guided by detailed understanding of the key features and mechanisms of natural adhesives. A simple example of this is given by recent mimicry of gecko adhesive in photolithographically micropatterned polymers (Geim et al. 2003), an approach made possible by earlier studies elaborating the fine morphological detail and adhesive force of individual gecko foot setae (Autumn et al. 2000). In the case of secreted adhesives such as those employed by marine organisms, biomimetic efforts are only possible when there is basic understanding of the key macromolecular components and their compositions. In the case of barnacle adhesives only limited information is known about the adhesive mechanism and component proteins (Naldrett and Kaplan 1997; Kamino et al. 2000; Kamino 2001), providing little guidance to biomimetic efforts. Such is not the case with mussel adhesive proteins (MAPs), which have been extensively studied and the subject of numerous biomimetic efforts. We begin with a brief review of the unique chemical features of MAPs, a subject that is discussed in greater detail in a recent review (Waite et al. 2005) and in Chap. 7 of the present volume. Several 13 Biomimetic Adhesive Polymers Based on Mussel Adhesive Proteins
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