Xerosis Means “Dry Skin”: Mechanisms, Skin Conditions, And Its Management
Published 2014 · Medicine
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Dry skin is common in the general population. In this chapter, epidermal homeostasis will be reviewed as well as the fundamental basics to understand the mechanisms by which the skin becomes dry or xerotic. Dry skin can be a simple status of the skin and does not necessarily reflect any cutaneous disease. Very dry skin, common at certain ages or environmental conditions, can, however, induce skin disease. Certain cutaneous diseases show scaly and dry skin as a primary clinical manifestation. These diseases are mentioned too. Finally, I will review how to prevent and how to manage dry skin, a common objective if I want to achieve a healthy skin.
This paper references
Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis.
Y. Werner (1985)
Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle.
A. V. Rawlings (2005)
Stratum corneum defensive functions: an integrated view.
P. Elias (2005)
Filaggrin mutations in children with severe atopic dermatitis.
N. Morar (2007)
Filaggrin loss‐of‐function mutation R501X and 2282del4 carrier status is associated with fissured skin on the hands: results from a cross‐sectional population study
J. Thyssen (2012)
Effects of pantothenic acid on fibroblastic cell cultures
B. Lacroix (1988)
One remarkable molecule: Filaggrin
S. Brown (2012)
Unique and Recurrent Mutations in the Filaggrin Gene in Singaporean Chinese Patients with Ichthyosis Vulgaris
Huijia Chen (2008)
How to choose a suitable emollient
C. Clark (2004)
New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions.
M. Cork (2006)
Studies on wound healing: effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture.
B. Weimann (1999)
Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly.
A. Sergeant (2009)
Xerosis: una disfunción de la barrera epidérmica
D. Barco (2008)
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1
K. List (2003)
Lipid content and lipid type as determinants of the epidermal permeability barrier.
G. Grubauer (1989)
The epidermal barrier function is dependent on the serine protease CAP1/Prss8
C. Leyvraz (2005)
Dermatitis de manos
C. Ramírez (2006)
Eczema, ichthyosis, psoriasis: conditions of cornification.
S. Burdette-Taylor (1995)
Evaluation of the hydration and the water-holding capacity in atopic skin and so-called dry skin.
P. Thune (1989)
Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum.
J. Sato (1998)
Effects of xerosis and ageing on epidermal proliferation and differentiation
M. Engelke (1997)
Profilaggrin, dry skin, and atopic dermatitis risk: size matters.
J. McGrath (2012)
Filaggrin mutations and atopy: consequences for future therapeutics
J. Heimall (2012)
SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing
T. Matsui (2011)
Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice.
C. Katagiri (2003)
Relationship between NMF (lactate and potassium) content and the physical properties of the stratum corneum in healthy subjects.
N. Nakagawa (2004)
Epidermal pathogenesis of inflammatory dermatoses.
P. Elias (1999)
Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin
Aileen Sandilands (2012)
Stratum corneum proteases and dry skin conditions
Anthony V. Rawlings (2012)
Effect of ethanol on liver 8-aminolaevulinate synthetase in rats.
B. Shanley (1968)
The content of free amino acids in the stratum corneum is increased in senile xerosis
M. Takahashi (2003)
Xerosis is latitude dependent and affects the propensity to develop atopic disease.
Jacob P. Thyssen (2012)
Cholesterol synthesis is required for cutaneous barrier function in mice.
K. Feingold (1990)
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases.
A. Kubo (2012)
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity.
S. Chamlin (2002)
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
C. Bonnart (2010)
Seasonal variation of skin resistance to irritants
T. Agner (1989)
X‐linked recessive ichthyosis: an impaired barrier function evokes limited gene responses before and after moisturizing treatments
T. Hoppe (2012)
The hands in health and disease of individuals with filaggrin loss‐of‐function mutations: clinical reflections on the hand eczema phenotype
J. Kaae (2012)
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
F. Smith (2006)
X-LINKED ICHTHYOSIS DUE TO STEROID-SULPHATASE DEFICIENCY
L. Shapiro (1978)
Ceramide and cholesterol composition of the skin of patients with atopic dermatitis.
A. Di Nardo (1998)
Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice
M. Hara (2003)
Signaling networks in barrier homeostasis. The mystery widens.
P. Elias (1996)
The management of dry skin with topical emollients – recent perspectives
E. Proksch (2005)
Filaggrin mutations increase the risk for persistent dry skin and eczema independent of sensitization.
M. Böhme (2012)
[Xerosis: a dysfunction of the epidermal barrier].
D. Barco (2008)
Low humidity and microtrauma.
R. J. Rycroft (1985)
The multifunctional role of filaggrin in allergic skin disease.
M. McAleer (2013)
The association between filaggrin mutations, hand eczema and contact dermatitis: a clear picture is emerging
J. Thyssen (2012)
Low humidity occupational dermatoses
R. J. Rycroft (1980)
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