Online citations, reference lists, and bibliographies.
← Back to Search

Effects On Pharmaceuticals In The Environment : An Overview And Principle Considerations

P. Pfluger, D. Dietrich
Published 2001 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
For the 2 684 and more than 3 000 pharmaceutical compounds registered in Germany (Rote Liste 2000) and Great Britain (Ayscough et al. 2000), respectively, the predominant proportion of the available information is characterised by data from preclinical and clinical studies. These data and respective peer- and non-peer reviewed literature can either be retrieved from the pharmaceutical companies themselves or in a more concentrated fashion from on-line databases, e.g. Toxnet (http://www.sis.nlm.nih.gov/ToxSearch.cfm), which includes information from databases such as HSDB, Genetox, Toxline etc., and from literature databases, e.g. MedLine, Biosis and Embase. Little information can be found, however, on the fate, transport and effects of these pharmaceuticals once they have been released into the environment (direct disposal and/or indirect disposal via sewage treatment plants, STPs). This paucity of data raises several questions: do the pharmaceuticals reach the environment and in what quantity? What are the known and potential acute, subchronic and chronic adverse effects of these compounds in exposed environmental species and the ecosystem as a whole?
This paper references
GC / MS analysis of organic compounds in domestic wastewaters
- GarrisonAi (1976)
10.1016/0024-3205(77)90329-0
Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicyclic acid in sewage water effluent.
C. Hignite (1977)
10.1093/toxsci/4.5.686
Diethylstilbestrol and other estrogens in the environment.
J. McLachlan (1984)
10.1016/0272-0590(84)90089-7
Diethylstilbestrol and Other Estrogens in the Environment
John A. Mclachlan (1984)
10.1111/j.2042-7158.1985.tb04922.x
The fate of pharmaceutical chemicals in the aquatic environment
M. Richardson (1985)
The fate of pharmaceutical chemicals in the environment
H Rittmannsberger (1985)
Untersuchungen zur aquatischen Toxizitat und zur endokrinenAktivitat VOn Carbamazepin. EUREGIO Okotoxikologie Service Labor The fate of pharmaceutical chemicals in the environment
P Pfluger (1985)
10.1016/0306-3623(86)90010-8
Effects of antiepileptic drugs on concentration of serum proteins and immunoglobulins of epileptic patients.
P. Garzón (1986)
10.2307/3433868
[Estrogens in the environment].
P. Podrouzek (1986)
10.1289/EHP.877525
Estrogens and development.
J. McLachlan (1987)
10.1001/JAMA.1987.03400100135040
Estrogens in the Environment II: Influences on Development
I. Schiff (1987)
Developmental Toxicology: Mechanisms and Risks
J. McLachlan (1988)
[Carbamazepine in the treatment of psychiatric diseases: effects and side effects].
H. Rittmannsberger (1990)
10.1111/j.1528-1157.1991.tb05622.x
Immunologic Aspects of Carbamazepine Treatment in Epileptic Patients
R. Pacifici (1991)
10.1111/j.1528-1157.1991.tb05605.x
Kindling Susceptibility and Genetic Seizure Predisposition in Inbred Mice
R. Green (1991)
Oral and injectable applications of erythromycin in salmonid fish culture.
C. Moffitt (1991)
10.1016/0045-6535(92)90480-F
Development, validation and limitations of toxic equivalency factors
S. Safe (1992)
10.1016/0192-0561(92)90121-Z
Immunomodulating properties of carbamazepine in mice.
R. Pacifici (1992)
Development, validation and limitations of toxic equivalent factors
Sh Safe (1992)
10.1289/EHP.93101386
Functional toxicology: a new approach to detect biologically active xenobiotics.
J. McLachlan (1993)
10.1111/j.1528-1157.1994.tb02934.x
Effects of Carbamazepine on Murine Humoral and Cellular Immune Responses
C. E. Andrade-Mena (1994)
Vorkommen von Clofibrinsäure in aquatischen System: Führt die therapeutische Anwendung zu einer Belastung von Oberflächen-, Grund- und Trinkwasser?
Hans-Jürgen Stan (1994)
Arzneiverordnungsreport '96. Aktuelle Daten, Kosten, Trends und KommentareDrug prescription report '96 current data, costs, trends and comments
U Schwabe (1994)
Frog embryo teratogenesis assay. Xenopus (FETAX).
W. Davies (1995)
10.1289/EHP.95103S73
Symposium on estrogens in the environment, III.
J. McLachlan (1995)
Symposium on estrogens in the em-ironment lll: Global health implications
Ja Mclachlan (1995)
Symposium on estrogens in the em - ironment lll : Global health implications
McLachlan jA (1995)
Vorkommen von polaren organischen Kontaminanten im Berliner Trinkwasser
T. Heberer (1996)
Nachweis von natürlichen und synthetischen Östrogenen in Kläranlagen und Fliessgewässern
M. Štumpf (1996)
Immunodepression induced by carbamazepine administration is mediated by CD 8+ spleen T cells.
Andrade-Mena Ce (1996)
Nachweis von Arzneimittelrückständen in Kläranlagen und Fliessgewässern
M. Stumpf (1996)
Immunodepression induced by carbamazepine administration is mediated by CD 8+ spleen T cells.
C E Andrade-Mena (1996)
Nachweis von natiirlichen und synthetischen Ostrogenen in K1araolagen und Fliessgewassern
Stumpf Lvi (1996)
10.1006/RTPH.1997.1102
Environmental hazard assessment of pharmaceuticals.
K. Henschel (1997)
Detection of drugs and drug metabolites in ground water samples of a drinking water treatment plant
T Heberer (1997)
10.1007/S002160051083
Methods for the determination of neutral drugs as well as betablockers and β2-sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS
T. Ternes (1998)
10.1006/FSIM.1998.0142
Influence of oxytetracycline and oxolinic acid on the immune response of rainbow trout (Oncorhynchus mykiss)
T. Lundén (1998)
10.1002/(SICI)1521-401X(199809)26:5<272::AID-AHEH272>3.0.CO;2-O
Occurrence and Distribution of Organic Contaminants in the Aquatic System in Berlin. Part I: Drug Residues and other Polar Contaminants in Berlin Surface and Groundwater
T. Heberer (1998)
10.1002/ETC.5620170305
Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater
Andreas Hartmann (1998)
Field trials of investigational new animal drugs.
C. Moffitt (1998)
10.1016/S0043-1354(98)00099-2
Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr. Klaus
T. Ternes (1998)
10.1016/S0045-6535(97)00354-8
Occurrence, fate and effects of pharmaceutical substances in the environment--a review.
B. Halling-Sørensen (1998)
10.1289/EHP.98106S41051
Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.
S. Safe (1998)
Methods for the determination of neutral drugs as well as betablockers and beta2-sympathomin!etics in aqueous matrices using
Ta Ternes (1998)
Occurrence , fate and effects of pharmaceutical substances in the emironment
B Halling-Smensen (1998)
Occurrence ofdrugs in German sewage treatment plants and rivers
TA Ternes (1998)
Danio rerio embryotoxicity and teratogenicity assay (DRJ:.1A) for detecting waterborne embryo-toxicants and teratogens
Dr Dietrich (1998)
10.1016/S0048-9697(98)00334-9
Behavior and occurrence of estrogens in municipal sewage treatment plants--I. Investigations in Germany, Canada and Brazil.
T. Ternes (1999)
10.1093/TOXSCI/48.2.151
Concise review of the cytochrome P450s and their roles in toxicology.
C. J. Omiecinski (1999)
10.1016/S0048-9697(98)00337-4
Occurrence of antibiotics in the aquatic environment.
R. Hirsch (1999)
10.1016/S0165-2427(98)00232-3
Effect of florfenicol on the immune response of rainbow trout (Oncorhynchus mykiss).
T. Lundén (1999)
Fish embryotoxicity and teratogenicity of pharmaceuticals , detergents and pesticides regularly detected in sewage treatment plant efiJuents and surface waters
DR Dietrich (1999)
In vivo and in vitro effect of oxytetracycline treatment on the in ! mune response of turbot , ScophthalmLIS maximus ( L )
TA Temes (1999)
In vivo and in vitro effect of oxytetracycline treatment on the in!mune response of turbot, ScophthalmLIS maximus (L)
C Tafalla (1999)
10.1016/S0045-6535(99)00453-1
Environmental risk assessment of human pharmaceuticals in Denmark after normal therapeutic use.
F. Stuer-Lauridsen (2000)
10.1046/J.1365-2761.1999.00179.X
In vivo and in vitro effect of oxytetracycline treatment on the immune response of turbot, Scophthalmus maximus (L.)
C. Tafalla (2002)
Daphnia sp . , Acute inlmobilisation test and reproduction test
L Paris
OECD (1984b) Daphnia sp., Acute inlmobilisation test and reproduction test. GEeD Guidelines For Testing of Chemicals 202
Effect of f 1 orfenicol on the immune response of rainbow trout ( Oncorhynchus mykiss ) _
T Lunden
Nachweis von Arzneimittelriiclcstanden in Klaranlagen und FlieBgewassern
C Tafalla
I998) Occurrence of drugs in German sewage treatment plants and rivers
Ta Temes
IN (1996b) Nachweis von Arzneimittelriiclcstanden in Klaranlagen und FlieBgewassern
M Stumpf
Liitzh0ft H, Halling-S0rensen B (2000) Em-ironmental risk assessment of human pharmaceuticals in Denmark after normal therapeutic use
F Stuer-Lauridsen
999) Effect of f1orfenicol on the immune response of rainbow trout (Oncorhynchus mykiss)_ Vet Immunol ImmunopathoI67
T Lunden
Danio rerio embryotoxicity and teratogenicity assay ( DRJ : . 1 A ) for detecting waterborne embryo - toxicants and teratogens
DR Dietrich
E '439-91. .-\rnerican Society for Testing and Materials
Nachweis von natiirlichen und synthetischen Ostrogenen in K 1 araolagen und Fliessgewassern
M Stumpf



This paper is referenced by
10.3390/W13091159
Pharmaceutical and Personal Care Products in Different Matrices: Occurrence, Pathways, and Treatment Processes
N. Reyes (2021)
10.1007/978-3-030-35237-0_3
The Impact of the Pharmaceutical Industry of Hyderabad in the Pollution of the Godavari River
S. D'Sa (2020)
10.1016/j.envpol.2020.114078
Effects of two little-studied environmental pollutants on early development in anurans.
V. Bókony (2020)
10.1016/J.SEPPUR.2018.10.031
Advanced and green ozonation process for removal of clofibric acid in water system: Preparation and mechanism analysis of efficient copper-substituted MCM-48
Shangyi Li (2019)
10.1016/j.scitotenv.2019.03.334
Investigation of medicines consumption and disposal in Brazil: A study case in a developing country.
G. Quadra (2019)
10.1016/j.scitotenv.2019.02.129
Algal-based removal strategies for hazardous contaminants from the environment - A review.
S. Tolboom (2019)
10.1002/9781119312321.ch8
Ecotoxicity of Pharmaceuticals and Personal Care Products
(2018)
Fate and effects of waterborne contaminants of emerging concern in the soil-plant system : impact of biochar soil amendment to mitigate their plant uptake
C. Cervera (2017)
10.1007/s11356-016-6907-7
Assessment of the effects of the carbamazepine on the endogenous endocrine system of Daphnia magna
A. Oropesa (2016)
10.2166/wst.2015.079
Clofibric acid and gemfibrozil removal in membrane bioreactors.
Tania Gutiérrez‐Macías (2015)
Environmental risk classification of candidates for new antibacterial agents through chemical experiments : A possible tool to improved environmentally sustainable drug development
C. Tang (2015)
10.1201/B17031-7
Health Impact of Pharmaceuticals in the Environment and in Drinking Water: Potential for Human and Environmental Risk
J. Smith (2014)
Ecotoxicological Aspects of Pharmaceuticals on Aquatic Environment
P. Giri (2014)
10.1201/B17031-4
Presence and Fate of Pharmaceuticals in the Environment and in Drinking Water
J. Smith (2014)
10.1016/j.etap.2014.10.013
Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures.
M. Saravanan (2014)
10.1007/s11783-013-0622-0
Removal of clofibric acid from aqueous solution by polyethylenimine-modified chitosan beads
Y. Nie (2014)
10.1016/j.tiv.2014.05.002
Effects of clofibric acid alone and in combination with 17β-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout.
I. Sovadinová (2014)
Adsorção de ibuprofeno e ácido clofíbrico em carvões activados
Patrick Figueiredo (2012)
RECOVERY PROCESS OF SALICYLIC ACID FROM LAMIVUDINE AND REDUCING ITS IMPACTS ON ENVIRONMENT BY USING THE REC OVERY AND MANUFACTURING PROCESS
M. S. Babu (2012)
10.1016/J.JKSUS.2011.01.001
Carbamazepine (CBZ) induced enzymatic stress in gill, liver and muscle of a common carp, Cyprinus carpio
A. Malarvizhi (2012)
10.1016/j.etap.2011.12.024
Eco-toxicological effect of carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa.
Wei Zhang (2012)
10.1080/09593330.2010.525750
UV and VUV photolysis vs. UV/H2O2 and VUV/H2O2 treatment for removal of clofibric acid from aqueous solution
Wenzhen Li (2011)
FACULTY OF BIOSCIENCE ENGINEERING CENTER FOR ENVIRONMENTAL SANITATION Academic Year 2010 – 2011 ELECTROCHEMICAL OXIDATION/REDUCTION OF TRACE ORGANICS USING BORON-DOPED DIAMOND (BDD) ELECTRODES
Miriam C Ruth (2011)
10.1016/j.jhazmat.2011.08.029
Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: hematological, biochemical, ionoregulatory and enzymological responses.
M. Saravanan (2011)
10.1016/J.CHEMOSPHERE.2009.10.053
Reply to discussion by Reinhard Länge et al. on “Degradation of the endocrine disrupting chemicals (EDCs) carbamazepine, clofibric acid, and iopromide by corona discharge over water” [Chemosphere 75(2) (2009) 163–168]
H. Krause (2010)
10.1016/J.CARBON.2009.11.013
Effect of solution pH on the removal of clofibric acid by cork-based activated carbons
A. Mestre (2010)
10.1016/j.jhazmat.2009.10.100
Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment.
L. Santos (2010)
10.1016/j.watres.2009.09.049
Oxidation of atenolol, propranolol, carbamazepine and clofibric acid by a biological Fenton-like system mediated by the white-rot fungus Trametes versicolor.
E. Marco-Urrea (2010)
cotoxicological aspects related to the presence of pharmaceuticals in the quatic environment
úcia H. M. L. M. Santosa (2009)
10.1016/j.jhazmat.2009.07.110
Identification of intermediates and assessment of ecotoxicity in the oxidation products generated during the ozonation of clofibric acid.
R. Rosal (2009)
10.1016/j.ecoenv.2007.12.006
Behaviour and biomarkers of oxidative stress in Gambusia holbrooki after acute exposure to widely used pharmaceuticals and a detergent.
B. Nunes (2008)
10.1007/S00216-006-0781-Y
LC-MS analysis and environmental risk of lipid regulators
M. Hernando (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar