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Major Vascular Resection In Pancreatic Carcinoma

Karl-Frederick Karstens, Y. Vashist, J. Izbicki
Published 2017 · Medicine

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Pancreatic cancer (PDAC) is one of the leading causes of cancer-related death worldwide. The incidence of PDAC is rising and mortality despite the effort to develop and implement new therapeutic strategies is increasing [1] (The Cancer Statistics Review (2009–2013) online). The major problem to improve individual survival rates is the delayed diagnosis of PDAC. Consequently, the majority of patients have to be excluded from surgical resection due to an already distant spread or locally advancement of the disease. Hence, only 10–20% of PDAC patients are primarily eligible for potential curative surgical approach aiming at a complete oncologic resection of the carcinoma with negative margins (R0). Despite controversies in definition of true R0 resection in PDAC and lessons learned in histological workup of the specimen, tumor-free resection margins still remain the goal of radical operation in PDAC with a reported prolonged survival of 5-year survival rates of up to 25% in selected series [2–7].
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