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An Insight Into Characterizations And Applications Of Nanoparticulate Targeted Drug Delivery Systems
A. K. Barui, B. Jana, J. Ryu
Published 2019 · Chemistry
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Nanoparticle-based targeted drug delivery system (DDS) is one of the major applications of nanotechnology in modern biomedical research. Basically, it comprises of bare or functionalized biocompatible nanoparticles with or without targeting ligands and one or more chemotherapeutic drugs. While the targeting efficacy of DDS without targeting ligands involves passive targeting through enhanced permeability and retention (EPR) effect, DDS containing targeting ligands (e.g., protein, antibodies, peptides, and small molecules) relies on their specificity to cell surface receptors. To achieve combination therapy, two or more chemotherapeutic drugs (exhibiting synergistic effect) are often loaded on nanoparticulate DDS. Besides site-specific delivery, the release of drugs from the DDS and stability of nanomaterials are also important factors to develop an effective nanomedicine that could overcome the disadvantages (e.g., nonspecificity, less bioavailability, and adverse side effect) associated with conventional treatment strategies of different diseases. To comprehend the drug release, stability of nanomaterials as well as ultimate therapeutic applications of DDS, it is highly essential to gradually develop and understand relevant physicochemical and biological characterization techniques. In view of the rapid growth of modern biomedical research involving drug delivery, it might be speculated that many nanomedicines based on DDS would come up in near future for practical therapeutic applications in human.
This paper references
Charge-Convertible Carbon Dots for Imaging-Guided Drug Delivery with Enhanced in Vivo Cancer Therapeutic Efficiency.
T. Feng (2016)
Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation.
H. M. Redhead (2001)
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
T. Xia (2008)
A luminescent nanoporous hybrid material based drug delivery system showing excellent theranostics potential for cancer.
A. Modak (2013)
Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery.
Tong Chen (2013)
Characterization of Crystalline Drug Nanoparticles Using Atomic Force Microscopy and Complementary Techniques
H. Shi (2004)
Noncovalent Surface Locking of Mesoporous Silica Nanoparticles for Exceptionally High Hydrophobic Drug Loading and Enhanced Colloidal Stability.
L. Palanikumar (2015)
Carbon nanotechnology : recent developments in chemistry, physics, materials science and device applications
Liming Dai (2006)
Polymer-iron oxide composite nanoparticles for EPR-independent drug delivery.
J. Park (2016)
Colloidal Stability of Silk Fibroin Nanoparticles Coated with Cationic Polymer for Effective Drug Delivery.
Suhang Wang (2015)
Cloaking nanoparticles with protein corona shield for targeted drug delivery
Jun Yong Oh (2018)
Natural Polymer Drug Delivery Systems: Nanoparticles, Plants, and Algae
Saurabh Bhatia (2016)
Performance of Doxorubicin-Conjugated Gold Nanoparticles: Regulation of Drug Location.
Teng Cui (2017)
A new in vitro technique for the evaluation of drug release profile from colloidal carriers - ultrafiltration technique at low pressure
B. Magenheim (1993)
pH-Sensitive ZnO Quantum Dots-Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery.
XiaoLi Cai (2016)
Bioinspired enzyme encapsulation for biocatalysis.
Lorena Betancor (2008)
Oriented catalytic platinum nanoparticles on high surface area strontium titanate nanocuboids.
J. A. Enterkin (2011)
A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy.
N. Cho (2011)
FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol
A. León (2017)
Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.
J. R. Hwu (2009)
Targeted drug delivery to tumors: myths, reality and possibility.
Y. Bae (2011)
A green chemistry approach for the synthesis of gold nanoconjugates that induce the inhibition of cancer cell proliferation through induction of oxidative stress and their in vivo toxicity study.
S. Mukherjee (2015)
PEGylated nanographene oxide for delivery of water-insoluble cancer drugs.
Zhuang Liu (2008)
Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin
S. D. Brown (2010)
Noncovalent Polymer‐Gatekeeper in Mesoporous Silica Nanoparticles as a Targeted Drug Delivery Platform
L. Palanikumar (2015)
Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis
Y. Li (2016)
Synthesis of silver nanoparticles for the dual delivery of doxorubicin and alendronate to cancer cells.
F. Benyettou (2015)
The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers.
Q. Li (2009)
Gold nanoparticles as novel agents for cancer therapy.
S. Jain (2012)
Passive and active drug targeting: drug delivery to tumors as an example.
V. Torchilin (2010)
meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity
T. Gayathri (2014)
Doxorubicin-Incorporated Nanotherapeutic Delivery System Based on Gelatin-Coated Gold Nanoparticles: Formulation, Drug Release, and Multimodal Imaging of Cellular Internalization.
S. Suarasan (2016)
Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine
S. Libutti (2010)
Investigation of the role of nitric oxide driven angiogenesis by zinc oxide nanoflowers.
A. K. Barui (2017)
Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery.
J. Chen (2014)
Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors.
L. Meng (2012)
Toxicology of nanoparticles.
A. Elsaesser (2012)
Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: Synthesis, characterization, and anticancer assessment.
Seyed-Behnam Ghaffari (2017)
To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery.
F. Danhier (2010)
Nanoparticle arrays on surfaces for electronic, optical, and sensor applications.
A. N. Shipway (2000)
Atomic Force Microscopy Studies of Solid Lipid Nanoparticles
A. Mühlen (2004)
Lidocaine loaded biodegradable nanospheres. II. Modelling of drug release.
M. Polakovič (1999)
Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment.
Rajesh Kotcherlakota (2016)
Applications of colloidal inorganic nanoparticles: from medicine to energy.
Samuel E. Lohse (2012)
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
N. Nasongkla (2006)
Polymer-coated liposomes; stability and release of ASA from carboxymethyl chitin-coated liposomes
C. Dong (1991)
Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier.
Pallab Sanpui (2011)
Nanoparticles and Nanowires for Cellular Engineering
J. Winter (2007)
Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery.
Jingyi Chen (2008)
Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44+ cancer cells
Jianming Liang (2015)
Hyaluronic acid-gold nanoparticle/interferon α complex for targeted treatment of hepatitis C virus infection.
M. Lee (2012)
Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy
L. Palanikumar (2018)
Hyaluronic acid co-functionalized gold nanoparticle complex for the targeted delivery of metformin in the treatment of liver cancer (HepG2 cells).
C. Senthil Kumar (2015)
P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells.
Ruibin Li (2010)
Potential application of functional porous TiO2 nanoparticles in light-controlled drug release and targeted drug delivery.
T. Wang (2015)
The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2.
Jinfeng Ren (2012)
Applications of nanomaterials in agricultural production and crop protection: A review
Lav R. Khot (2012)
Physicochemical characterization of polyacrylic nanoparticles
J. Kreuter (1983)
Carbon-Dot-Coated Alginate Beads as a Smart Stimuli-Responsive Drug Delivery System.
S. Majumdar (2016)
Therapeutic Nanoparticles for Drug Delivery in Cancer
Kwangjae Cho (2008)
pH-Sensitive drug delivery system based on modified dextrin coated mesoporous silica nanoparticles.
H. Chen (2016)
Study on montmorillonite/insulin/TiO2 hybrid nanocomposite as a new oral drug-delivery system.
Younes Kamari (2017)
PEGylated Nanoparticles for Biological and Pharmaceutical Applications
H. Otsuka (2003)
Glutathione-triggered "off-on" release of anticancer drugs from dendrimer-encapsulated gold nanoparticles.
Xinyu Wang (2013)
Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells.
Zhou Han (2015)
Curcumin-loaded silica-based mesoporous materials: Synthesis, characterization and cytotoxic properties against cancer cells.
V. S. Bollu (2016)
Chapter Green Nanotechnology: Development of Nanomaterials for Environmental and Energy Applications
R. Fagan (2013)
Antiangiogenic activity of mononuclear copper(II) polypyridyl complexes for the treatment of cancers.
P. Nagababu (2015)
Nanotechnology and nanomedicine: going small means aiming big.
M. K. Teli (2010)
Biodegradable nanoparticles as a delivery system for cyclosporine: preparation and characterization.
J. Molpeceres (2000)
Doxorubicin conjugated gold nanoparticles as water-soluble and pH-responsive anticancer drug nanocarriers
S. Aryal (2009)
Nanoscience: The Science of the Small in Physics, Engineering, Chemistry, Biology and Medicine
H. Schaefer (2010)
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy.
Qimeng Quan (2011)
Folic acid protected silver nanocarriers for targeted drug delivery.
Y. Wang (2012)
Functionalized Silica Nanoparticles As an Alternative Platform for Targeted Drug-Delivery of Water Insoluble Drugs.
L. F. de Oliveira (2016)
Cancer cell-selective promoter recognition accompanies antitumor effect by glucocorticoid receptor-targeted gold nanoparticle.
S. Sau (2014)
Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy.
K. Jores (2004)
Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes.
X. Zhang (2009)
Fabrication of chitosan/poly(lactic acid)/graphene oxide/TiO2 composite nanofibrous scaffolds for sustained delivery of doxorubicin and treatment of lung cancer.
S. Samadi (2018)