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Drug Delivery To Skin By Needle-Free Injector

H. Todo
Published 2017 · Medicine

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The transdermal drug delivery system (TDDS) has several advantages including the avoidance of the hepatic first-pass effect of drugs, long-acting sustained release of drugs, improved patient compliance, and painless administration. However, traditional TDDS has a limitation for the molecular size of drugs (<500 Da). Thus, TDDS formulations are not suitable for administration of high molecular hydrophilic drugs, such as proteins and vaccines. To overcome this problem, physicochemical methods, such as electroporation, microneedle, and needle-free injection (NFI), are becoming popular to increase skin permeation of mal-absorptive drugs. Among these techniques, NFIs have been investigated as an administration device not only for high molecular weight compounds like insulin and human-growth hormone, but also for vaccine and gene delivery. Currently biotechnology-derived medications are the leading edge of medical treatment and many biopharmaceuticals have dominated the top 10 used agents in the global market. In the near feature, development of self-administered injectable biopharmaceuticals associated with NFI or a combination of NFI and new transdermal drug innovative technologies will be needed to be able to incorporate and used into normal routines within patients’ homes and work places.
This paper references
10.1089/VIM.2005.18.205
Needle-free jet injection of a mixture of Japanese encephalitis DNA and protein vaccines: a strategy to effectively enhance immunogenicity of the DNA vaccine in a murine model.
Jun-ichi Imoto (2005)
10.2337/diacare.16.11.1479
Jet-Injected Insulin Is Associated With Decreased Antibody Production and Postprandial Glucose Variability When Compared With Needle-Injected Insulin in Gestational Diabetic Women
L. Jovanovic-Peterson (1993)
10.1177/0091270002238772
No Effect of the Novel Antidiabetic Agent Nateglinide on the Pharmacokinetics and Anticoagulant Properties of Warfarin in Healthy Volunteers
D. Anderson (2002)
10.1016/S0025-6196(12)65585-2
Comparison of plasma insulin profiles after subcutaneous administration of insulin by jet spray and conventional needle injection in patients with insulin-dependent diabetes mellitus.
G. Pehling (1984)
10.1007/BF02072205
Risks of jet injection of insulin in children
G. Theintz (2005)
10.1016/J.ADDR.2003.10.023
Microneedles for transdermal drug delivery.
M. Prausnitz (2004)
10.1055/s-2007-1011842
Blood glucose and free insulin levels after the administration of insulin by conventional syringe or jet injector in insulin treated type 2 diabetics.
G. Kerum (1987)
10.2337/dc11-0182
Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology
E. Engwerda (2011)
10.1016/j.jconrel.2009.01.003
Dynamic control of needle-free jet injection.
J. Stachowiak (2009)
10.1016/J.IJPHARM.2006.12.040
Dermatopharmacokinetics of salicylate following topical injection in rats: effect of osmotic pressure and injection volume on salicylate disposition.
D. Yoshida (2007)
10.1016/J.JCONREL.2004.04.006
Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power.
Joy Schramm-Baxter (2004)
10.1034/j.1600-0625.2000.009003165.x
The 500 Dalton rule for the skin penetration of chemical compounds and drugs
J. Bos (2000)
Comparison of the safety and efficacy of a recombinant feline leukemia virus (FeLV) vaccine delivered transdermally and an inactivated FeLV vaccine delivered subcutaneously.
D. Grosenbaugh (2004)
10.1002/jps.2600510825
Analysis of data on the medicament release from ointments.
W. Higuchi (1962)
10.1177/009127002762491361
Pharmacokinetics and Pharmacodynamics of a New Formulation of Recombinant Human Growth Hormone Administered by ZomaJet 2 Vision, a New Needle‐Free Device, Compared to Subcutaneous Administration Using a Conventional Syringe
H. Agersø (2002)
10.1016/j.ijpharm.2008.01.005
Effect of vasoactive agents on the dermatopharmacokinetics and systemic disposition of model compounds, salicylate and FITC-dextran 4 kDa, following intracutaneous injection of the compounds.
D. Yoshida (2008)
10.1016/J.JCONREL.2005.05.023
Jet-induced skin puncture and its impact on needle-free jet injections: experimental studies and a predictive model.
Joy Baxter (2005)
10.1023/A:1020753329492
Transdermal Drug Delivery by Jet Injectors: Energetics of Jet Formation and Penetration
J. Schramm (2004)
10.1016/j.ejps.2008.04.003
Effect of molecular weight on the dermatopharmacokinetics and systemic disposition of drugs after intracutaneous injection.
D. Yoshida (2008)
Intradermal vaccination for Mycoplasma hyopneumoniae
G. Jones (2005)
10.1016/S0264-410X(01)00225-0
Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needle-free jet injectors.
L. Jackson (2001)
10.1016/0168-3659(87)90034-4
A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
P. L. Ritger (1987)
10.1016/j.vaccine.2011.09.097
Safety, tolerability, and immunogenicity of inactivated trivalent seasonal influenza vaccine administered with a needle-free disposable-syringe jet injector.
J. Simon (2011)
10.1016/J.JCONREL.2003.12.014
Mechanism of the synergic effects of calcium chloride and electroporation on the in vitro enhanced skin permeation of drugs.
Y. Tokudome (2004)
10.1016/0378-5173(96)04488-2
Fundamental investigation of a novel drug delivery system, a transdermal delivery system with jet injection
N. Inoue (1996)
10.1186/1472-6904-7-10
Pharmacokinetics of recombinant human growth hormone administered by cool.click™ 2, a new needle-free device, compared with subcutaneous administration using a conventional syringe and needle
C. Brearley (2007)
10.1016/S0140-6736(14)60524-9
Needle-free jet injection for administration of influenza vaccine: a randomised non-inferiority trial
L. Mcallister (2014)
10.1016/S0264-410X(99)00446-6
Hepatitis A vaccine administration: comparison between jet-injector and needle injection.
J. Williams (2000)
10.1007/BF00192361
Pharmacokinetics and pharmacodynamics of a single dose of recombinant human growth hormone after subcutaneous administration by jet-injection: comparison with conventional needle-injection
A. Verhagen (1995)
10.1186/1472-6904-7-1
Heterogeneity of human adipose blood flow
D. Levitt (2007)
10.1016/J.JCONREL.2007.08.017
Piezoelectric control of needle-free transdermal drug delivery.
J. Stachowiak (2007)
10.1034/j.1600-0625.2000.009001001.x
Role of neutrophils in induction of acute inflammation in T‐cell‐mediated immune dermatosis, psoriasis: A neutrophil‐associated inflammation‐boosting loop
T. Terui (2000)
10.1073/pnas.0700182104
Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets
A. Arora (2007)
10.1016/j.drudis.2015.06.007
Therapeutic transdermal drug innovation from 2000 to 2014: current status and outlook.
J. Walter (2015)



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