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The Role Of CD81 In HCV And Plasmodium Infection

L. Cocquerel, O. Silvie
Published 2013 · Biology

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Hepatitis C and malaria, two of the most prevalent infectious diseases in the world, are caused by Hepatitis C virus (HCV) and Plasmodium parasites, respectively. Both HCV particles and Plasmodium sporozoites, the mosquito-­transmitted stage of the malaria parasite, infect and replicate in the liver. Whereas HCV enters cells by clathrin-mediated endocytosis, Plasmodium sporozoite invasion is a specific active process that relies on the parasite motility machinery. Remarkably, both pathogens critically depend on the host tetraspanin CD81 to enter hepatocytes. In this chapter, we summarize the current knowledge on the role of CD81, tetraspanin-enriched microdomains and CD81-associated partners during HCV and Plasmodium liver infection.
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M. Dreux (2007)
10.1128/JVI.01091-07
Human Apolipoprotein E Is Required for Infectivity and Production of Hepatitis C Virus in Cell Culture
Kyungsoo Chang (2007)
10.1128/JVI.00127-07
The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein
F. Helle (2007)
10.1128/JVI.02053-07
Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion
P. Gastaminza (2007)
10.1016/J.JHEP.2006.09.024
The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus.
S. Molina (2007)
10.1111/j.1462-5822.2007.00972.x
Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection
Ursula Andréo (2007)
10.2353/AJPATH.2007.060789
Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes.
C. Lázaro (2007)
10.1073/pnas.0700760104
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins
H. Huang (2007)
10.1128/JVI.01573-06
CD81 Expression Is Important for the Permissiveness of Huh7 Cell Clones for Heterogeneous Hepatitis C Virus Infection
D. Akazawa (2007)
10.1128/JVI.01457-07
Claudin-6 and Claudin-9 Function as Additional Coreceptors for Hepatitis C Virus
Aihua Zheng (2007)
10.1128/JVI.02627-06
Human Serum Amyloid A Protein Inhibits Hepatitis C Virus Entry into Cells
Zhaohui Cai (2007)
10.1002/hep.21994
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81
M. Zeisel (2007)
10.1128/JVI.00193-07
High-Avidity Monoclonal Antibodies against the Human Scavenger Class B Type I Receptor Efficiently Block Hepatitis C Virus Infection in the Presence of High-Density Lipoprotein
M. Catanese (2007)
10.1128/JVI.01894-07
Effect of Cell Polarization on Hepatitis C Virus Entry
C. Mee (2007)
10.1002/JMV.20842
The roles of CD81 and glycosaminoglycans in the adsorption and uptake of infectious HCV particles
K. Morikawa (2007)
10.21775/cimb.009.071
Assembly of a functional HCV glycoprotein heterodimer.
M. Lavie (2007)
10.1128/JVI.02622-06
Sulfated Homologues of Heparin Inhibit Hepatitis C Virus Entry into Mammalian Cells
A. Basu (2007)
10.1128/JVI.00459-07
Hepatitis C Virus Envelope Glycoprotein E2 Glycans Modulate Entry, CD81 Binding, and Neutralization
E. Falkowska (2007)
10.1099/VIR.0.82567-0
Mutagenesis of a conserved fusion peptide-like motif and membrane-proximal heptad-repeat region of hepatitis C virus glycoprotein E1.
H. Drummer (2007)
10.1016/j.pt.2008.08.006
Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma.
J. Baum (2008)
10.1371/journal.ppat.1000010
Hepatocyte Permissiveness to Plasmodium Infection Is Conveyed by a Short and Structurally Conserved Region of the CD81 Large Extracellular Domain
Samir Yalaoui (2008)
10.1128/JVI.01888-08
Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection
Shufeng Liu (2008)
10.1111/j.1462-5822.2007.01070.x
Ceramide enrichment of the plasma membrane induces CD81 internalization and inhibits hepatitis C virus entry
C. Voisset (2008)
10.1371/journal.pone.0002660
Direct Infection and Replication of Naturally Occurring Hepatitis C Virus Genotypes 1, 2, 3 and 4 in Normal Human Hepatocyte Cultures
M. Buck (2008)
10.1016/J.BBAMEM.2007.07.012
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
Andrea Hartsock (2008)
10.1099/vir.0.83386-0
Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
A. Owsianka (2008)
10.1074/jbc.M709824200
Correlation of the Tight Junction-like Distribution of Claudin-1 to the Cellular Tropism of Hepatitis C Virus*
Wei Yang (2008)
10.1128/JVI.01977-07
The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus
L. Meertens (2008)
10.1002/hep.21959
Hepatitis C virus cell‐cell transmission in hepatoma cells in the presence of neutralizing antibodies
J. Timpe (2007)
10.1128/JVI.00914-08
Apolipoprotein C1 Association with Hepatitis C Virus
J. Meunier (2008)
10.1128/JVI.02286-07
CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus Entry
H. J. Harris (2008)
10.1186/1471-2180-9-111
The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry
Vera Rocha-Perugini (2009)
10.1371/journal.pone.0001866
The CD81 Partner EWI-2wint Inhibits Hepatitis C Virus Entry
V. Rocha-Perugini (2008)
10.1016/j.chom.2008.07.013
Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection.
Samir Yalaoui (2008)
10.1002/hep.22547
Anti‐CD81 antibodies can prevent a hepatitis C virus infection in vivo
P. Meuleman (2008)
10.1371/journal.pone.0003549
Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes
Ben C. L. van Schaijk (2008)
10.1529/biophysj.107.126896
Interaction of the most membranotropic region of the HCV E2 envelope glycoprotein with membranes. Biophysical characterization.
A. J. Pérez-Berná (2008)
10.1016/j.bbalip.2008.01.003
PCSK9: an enigmatic protease.
D. Lopez (2008)
10.1128/JVI.00665-08
CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes
M. Brazzoli (2008)
10.1016/j.bbamem.2008.03.018
The pre-transmembrane region of the HCV E1 envelope glycoprotein: interaction with model membranes.
A. J. Pérez-Berná (2008)
10.1016/j.chom.2008.07.012
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection.
C. D. Rodrigues (2008)
10.1128/JVI.02199-08
Role of SR-BI in HCV entry: kinetics and molecular determinants
M. T. Catanese (2009)
10.1186/1741-7015-7-48
Human cellular restriction factors that target HIV-1 replication
K. Strebel (2009)
10.1128/JVI.02199-08
Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants
M. Catanese (2009)
10.1074/jbc.M109.014647
Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus Particles*
S. Haid (2009)
10.1128/JVI.01476-09
Apolipoprotein E but Not B Is Required for the Formation of Infectious Hepatitis C Virus Particles
Jieyun Jiang (2009)
10.1099/vir.0.006700-0
CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells
(2009)
10.1371/journal.ppat.1000310
Receptor Complementation and Mutagenesis Reveal SR-BI as an Essential HCV Entry Factor and Functionally Imply Its Intra- and Extra-Cellular Domains
M. Dreux (2009)
10.1128/JVI.00246-09
Polarization Restricts Hepatitis C Virus Entry into HepG2 Hepatoma Cells
C. Mee (2009)
10.1111/j.1365-2893.2009.01111.x
Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell‐culture‐derived H77/JFH1 chimeric infectious virus particles
R. Russell (2009)
10.1146/annurev.micro.091208.073403
Malaria parasite development in the mosquito and infection of the mammalian host.
A. Aly (2009)
10.1371/journal.ppat.1000702
RNA Interference and Single Particle Tracking Analysis of Hepatitis C Virus Endocytosis
K. Coller (2009)
10.1002/hep.22911
PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression
P. Labonté (2009)
10.1074/jbc.M109.057927
The Ig Domain Protein CD9P-1 Down-regulates CD81 Ability to Support Plasmodium yoelii Infection*
S. Charrin (2009)
10.1016/j.virol.2009.08.037
Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor.
D. Owen (2009)
10.1038/nature07684
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
A. Ploss (2009)
10.1016/j.ijpara.2008.10.007
Apicomplexan cytoskeleton and motors: key regulators in morphogenesis, cell division, transport and motility.
Joana Santos (2009)
10.1128/JVI.00038-09
The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection
I. Benedicto (2009)
10.1186/1423-0127-16-89
Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry
H. Li (2009)
10.1016/j.bbamem.2009.08.002
Biophysical characterization of the fusogenic region of HCV envelope glycoprotein E1.
A. J. Pérez-Berná (2009)
10.1002/hep.22673
Development and characterization of hepatitis C virus genotype 1‐7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
J. Gottwein (2009)
10.1128/JVI.01552-09
Hepatoma Cell Density Promotes Claudin-1 and Scavenger Receptor BI Expression and Hepatitis C Virus Internalization
Anne Schwarz (2009)
10.1128/IAI.00661-09
Tetraspanin CD81 Is Required for Listeria monocytogenes Invasion
T. N. Tham (2009)
10.1042/BJ20082422
Lateral organization of membrane proteins: tetraspanins spin their web.
S. Charrin (2009)
10.1042/BC20090125
Role of lipid metabolism in hepatitis C virus assembly and entry
Costin-Ioan Popescu (2010)
10.1371/journal.ppat.1000762
The Disulfide Bonds in Glycoprotein E2 of Hepatitis C Virus Reveal the Tertiary Organization of the Molecule
T. Krey (2010)
10.1128/JVI.02200-09
Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes
D. Bankwitz (2010)
10.1038/nbt.1604
Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system
C. T. Jones (2010)
10.1128/JVI.02391-09
Novel Function of CD81 in Controlling Hepatitis C Virus Replication
Y. Zhang (2010)
10.1073/pnas.0915130107
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures
A. Ploss (2010)
10.1128/JVI.01180-10
Characterization of the Envelope Glycoproteins Associated with Infectious Hepatitis C Virus
G. Vieyres (2010)
10.1099/vir.0.021071-0
Characterization of hepatitis C virus pseudoparticles by cryo-transmission electron microscopy using functionalized magnetic nanobeads.
P. Bonnafous (2010)
10.1002/hep.23445
Inhibition of hepatitis C virus infection by anti‐claudin‐1 antibodies is mediated by neutralization of E2–CD81–Claudin‐1 associations
Sophie E. Krieger (2010)
10.1053/j.gastro.2010.06.058
Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes.
P. Podevin (2010)
10.1002/hep.23278
Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles
Wagane J. A. Benga (2010)
10.1074/jbc.M110.104836
Claudin Association with CD81 Defines Hepatitis C Virus Entry
H. J. Harris (2010)
10.1053/j.gastro.2010.05.073
Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes.
Isabel Fofana (2010)
10.1128/JVI.02153-09
Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies
S. Dhillon (2010)
10.1128/JVI.01548-10
Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Proteins Incorporated into Infectious Virions
F. Helle (2010)
10.1128/JVI.05259-11
Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations
Z. Keck (2011)
10.1038/nature10168
A genetically humanized mouse model for hepatitis C virus infection
M. Dorner (2011)
10.1074/jbc.M111.220103
Interacting Regions of CD81 and Two of Its Partners, EWI-2 and EWI-2wint, and Their Effect on Hepatitis C Virus Infection*
C. Montpellier (2011)
10.1074/jbc.M111.263350
Hepatitis C Virus Is Primed by CD81 Protein for Low pH-dependent Fusion*
N. R. Sharma (2011)
10.1053/j.gastro.2011.01.001
A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease.
Michael L Washburn (2011)
10.1002/hep.25501
Role of low‐density lipoprotein receptor in the hepatitis C virus life cycle
Anna Albecka (2012)
10.1042/BJ20110868
Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2.
I. Boo (2012)
10.1111/cmi.12112
EWI‐2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry
Julie Potel (2013)



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