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Ideal Stem Cell Candidate For Regenerative Medicine: Pluripotent Stem Cells, Adult Stem Cells, Or Pluripotent Stem Cells In Adult Organs?

D. Bhartiya
Published 2017 · Biology

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A big divide was created among stem cell biologists because of ethical issues associated with human embryonic stem cells (hESCs). Adult stem cell biologists observed that hematopoietic stem cells (HSCs) in bone marrow possess considerable “plasticity” and could replace hESCs for regenerative medicine. As a result several trials using autologous bone marrow cells were undertaken; however, no significant success has been achieved. Human ESCs and induced pluripotent stem (iPS) cells tend to give rise to fetal counterparts and thus may not regenerate adult organs efficiently. Another novel population of pluripotent stem cells has also been reported in various adult organs termed very small embryonic-like stem cells (VSELs). VSELs explain the “plasticity” of the bone marrow/cord blood cells and have better differentiation potential compared to ES/iPS cells. Present article is an effort to make a case for pluripotent VSELs as ideal stem cell candidate for endogenous regeneration of diseased organs.
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