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The Modified Appleby Procedure For Locally Advanced Pancreatic Body/Tail Cancer: How I Do It

Aaron J. Lewis, H. F. Schoellhammer, G. Singh
Published 2018 · Medicine

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Tumors of the body and tail account for approximately one-third of pancreatic cancers, and up to three-quarters of body and tail tumors are deemed unresectable on presentation. Unresectability is a result of liver metastases, carcinomatosis, or local invasion of major vascular structures. Although pancreatectomy in the presence of metastatic disease has not proven beneficial, resection of locally advanced pancreatic cancer to negative margins may improve survival. Treatment of locally advanced pancreatic adenocarcinoma with arterial involvement remains controversial; however, 30% of patients with locally advanced, Stage III pancreatic cancer will die without evidence of metastatic spread. As such, this group of patients is most likely to benefit from an aggressive surgical approach. Neoadjuvant therapy has allowed for more careful selection of patients that may benefit from pancreatectomy with arterial resection. In this chapter, we discuss how we perform the modified Appleby procedure and review the literature.
This paper references
Modified Appleby Procedure for Resection of Tumors of the Pancreatic Body and Tail with Celiac Axis Involvement
Rory L Smoot (2012)
Usefulness of F-18-fluorodeoxyglucose positron emission tomography to confirm suspected pancreatic cancer: a meta-analysis.
A. P. Rijkers (2014)
Distal pancreatectomy, splenectomy, and celiac axis resection (DPS-CAR): common hepatic arterial stump pressure should determine the need for arterial reconstruction.
A. Mittal (2015)
Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-fluorouracil infusion for locally unresectable pancreatic cancer.
H. Shinchi (2002)
Distal pancreatectomy: indications and outcomes in 235 patients.
K. Lillemoe (1999)
Regional resection of cancer of the pancreas: a new surgical approach.
J. Fortner (1973)
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer.
T. Conroy (2011)
Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: gemcitabine versus 5-fluorouracil, a randomized controlled study.
Chung-Pin Li (2003)
Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial.
J. Neoptolemos (2010)
Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial.
W. Regine (2008)
Extended pancreatectomy with resection of the celiac axis: the modified Appleby operation.
S. Gagandeep (2006)
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine.
D. V. Von Hoff (2013)
A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282.
S. Cohen (2005)
Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5‐fluorouracil), and high dose radiation + 5‐fluorouracil. The gastrointestinal tumor study group
C. Moertel (1981)
Distal Pancreatectomy With En Bloc Resection of the Celiac Trunk for Extended Pancreatic Tumor Disease: An Interdisciplinary Approach
T. Denecke (2010)
Modified Appleby Procedure for Pancreatic Adenocarcinoma: Does Improved Neoadjuvant Therapy Warrant Such an Aggressive Approach?
N. A. Peters (2016)
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer.
J. Neoptolemos (2004)
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
H. Oettle (2007)
Arterial Resection During Pancreatectomy for Pancreatic Cancer: A Systematic Review and Meta-Analysis
N. Mollberg (2011)
Distal Pancreatectomy with en Bloc Celiac Axis Resection (Modified Appleby Procedure) for Locally Advanced Pancreatic Body Cancer: A Single-Center Review of 80 Consecutive Patients
T. Nakamura (2016)
The coeliac axis in the expansion of the operation for gastric carcinoma
L. Appleby (1953)
Modified Appleby procedure for borderline resectable/locally advanced distal pancreatic adenocarcinoma: A major procedure for selected patients.
M. Cesaretti (2016)
Distal pancreatectomy with celiac axis resection: what are the added risks?
Joal D. Beane (2015)
Arterial resection at the time of pancreatectomy for cancer.
Kathleen K Christians (2014)
Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study.
B. Chauffert (2008)
Full dose neoadjuvant FOLFIRINOX is associated with prolonged survival in patients with locally advanced pancreatic adenocarcinoma.
Moh’d Khushman (2015)
Techniques for prevention of pancreatic leak after pancreatectomy.
H. F. Schoellhammer (2014)
Stage III pancreatic cancer and the role of irreversible electroporation
Mohammad Al Efishat (2015)

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