Sleep Deprivation, Cognitive Functions, And Countermeasures
Published 2019 · Medicine
Sleep is necessary for the execution of cognitive functions. Sleep disturbance causes cognitive impairment in humans as well as rodents. Sleep is essential for neurogenesis, synaptic plasticity, and hippocampus-based memory consolidation. This process is impaired by sleep deprivation and may involve multiple pathways. Hippocampus is an essential player in the brain, which is involved in the execution of various cognitive functions and maintains neurogenesis and synaptic processes. At the same time, it is also more vulnerable to stress. Caffeine and modafinil are recognized psychostimulants, known to improve sleep deprivation-induced cognitive function decline in humans as well as animals. Caffeine and modafinil are well-evaluated countermeasures against sleep deprivation-induced alterations in the neuronal cell proliferation and synaptic plasticity mechanism. The article describes the sleep deprivation-induced deficit in cognitive function, its molecular mechanism, and the effect of psychostimulant drugs, caffeine, and modafinil.