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The Inhibition And Activation Of Polyamine Oxidase From Oat Seedlings

T. Smith
Published 2004 · Biology

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In a homologous series of di-guanidines (NH2C(−NH)NH(CH2)xNHC(−NH) NH2) where x=2−12, greatest inhibition of polyamine oxidase was found with x=8. The synthetic fungicide guazatine269-1 was particularly effective as an inhibitor of polyamine oxidase, with Ki of ca 10-8M. Inhibition due to the tri-amine derived from guazatine by hydrolysis was less effective by a factor of ca 200. Comparison of various inorganic salts at 1 M showed that polyamine oxidase activity was enhanced in the order RbCl>KCl>KBr>NH4Cl>NaNO3>LiCl>LiCl=NaCl> control (no salt) >CaCl2=MgCl2. Activity in RbCl was about 4 to 5 times greater than in the salt-free control. Enzyme activity is rapidly lost during assay. This loss of activity could not be attributed to inhibition by aminopropylpyrroline or diaminopropane. Moreover the superoxide scavenger copper salicylate had no protective effect on enzyme activity.
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