Online citations, reference lists, and bibliographies.

Somatostatin Receptor Scintigraphy With [111In-DTPA-d-Phe1]- And [123I-Tyr3]-octreotide: The Rotterdam Experience With More Than 1000 Patients

E. Krenning, D. Kwekkeboom, W. Bakker, W. Breeman, Peter P. M. Kooij, H. Oei, M. Hagen, P. Postema, M. Jong, J. Reubi, T. Visser, A. Reijs, L. Hofland, J. Koper, S. J. Lamberts
Published 2004 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Various tumours, classically specified as either neuroendocrine or non-neuroendocrine, contain high numbers of somatostatin receptors, which enable in vivo localization of the primary tumour and its metastases by scintigraphy with the radiolabelled somatostatin analogue octreotide. In addition granulomas and autoimmune processes can be visualized because of local accumulation of somatostatin receptor-positive activated mononuclear leucocytes. In many instances a positive scintigram predicts a favourable response to treatment with octreotide. It is tempting to speculate that octreotide labelled with an appropriate radionuclide might be used in cancer therapy. The successful application of radiolabelled octreotide in scintigraphy indicates the possible usefulness of other radiolabelled peptides, either native peptides or derivatives of these, in, for example, nuclear oncology. The small size of these peptides, e.g. bombesin and substance P, is of the utmost importance for a relatively fast blood clearance, thus leading to low background radioactivity. In this way peptides are powerful alternatives to (fragments of) monoclonal antibodies, the application of which to scintigraphic localization of specific cell surface antigen-bearing tumours is plagued by slow blood clearance and, hence, high background levels.
This paper references
10.1073/pnas.89.1.251
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
Y. Yamada (1992)
Molecular cloning and functional expression of a brain - specific somatostatin recep
Bruno Jf (1992)
Novel clinical application of [~25I-Tyr3]-octreotide. Fourth international congress on hormones and cancer; Amsterdam, 1991;abslr
AA Kafity (1993)
Octreotide. Lancet 1989;II:859-860
P Kendall-Taylor (1989)
10.1111/j.1365-2265.1992.tb00949.x
Pituitary imaging using a labelled somatostatin analogue in acromegaly
E. Ur (1992)
10.1111/j.1365-2265.1991.tb00311.x
Effects of antibodies against octreotide in two patients with acromegaly
H. Ørskov (1991)
In vivo application of [~H-In-DTPA-D-Phe~]-octreotide for detection of somatostatin receptor-positive tumours in rats
WH Bakker (1991)
10.1126/science.6126003
Quantitative electron microscopic autoradiography of insulin, glucagon, and somatostatin binding sites on islets.
Y. Patel (1982)
10.1073/pnas.89.23.11151
Molecular cloning and functional expression of a brain-specific somatostatin receptor.
J. F. Bruno (1992)
10.1210/jcem-68-4-844
The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status.
J. Reubi (1989)
10.1016/0024-3205(91)90052-D
[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validation.
W. Bakker (1991)
Treatment of patients with pancreatic endocrine tumours using a new long-acting somatostatin analogue SMS 201-995: symptomatic and peptide responses
SM Wood (1985)
10.1007/BF02258432
Radionuclide therapy revisited
C. Hoefnagel (2005)
Distinct subsets of somatostatin receptors on cultured human lymphocytes.
S. Sreedharan (1989)
10.1016/0002-9343(86)90580-2
Somatostatin: a peptide with unexpected physiologic activities.
P. Brazeau (1986)
Somatostatin receptors and somatostatin content in medullary thyroid carcinomas.
J. Reubi (1991)
Surgical therapy for endocrine tumors of abdominal origin
D. Sloan (1993)
Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer.
J. Foekens (1989)
10.1210/jcem.75.5.1430093
Clinically nonfunctioning pituitary adenoma and octreotide response to long term high dose treatment, and studies in vitro.
T. D. de Bruin (1992)
10.1210/jcem.74.3.1346787
Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth.
J. Koper (1992)
An odyssey in the land of small tumours
CG Moertel (1987)
Autoradiographic mapping of somatostatin receptors in the rat CNS and pituitary
JC Reubi (1985)
Octreotide and Graves' ophthalmopathy and myxoedema
TC Chang (1992)
In-vivo localization of somatostatin receptors with 1-123-Tyr-3-octreotide
W Becker (1992)
10.1007/BF02894068
Polypeptide hormone production by “Carcinoid” apudomas and their relevant cytochemistry
A. G. Pearse (1974)
10.1148/radiology.169.1.2843942
Common tumors of the parapharyngeal space: refined imaging diagnosis.
P. Som (1988)
tribution and biochemical characterization of somatostatin receptors in tumours of the human central nervous system
JC Reubi (1987)
10.1016/0166-2236(93)90050-V
Molecular biology of somatostatin receptors
G. Bell (1993)
10.1210/edrv-12-4-450
The role of somatostatin and its analogs in the diagnosis and treatment of tumors.
S. Lamberts (1991)
10.1001/archderm.1992.01680160102014
Somatostatin analogue scintigraphy. A simple and sensitive method for the in vivo visualization of Merkel cell tumors and their metastases.
D. Kwekkeboom (1992)
Somatostatin receptors in human renal cell carcinomas.
J. Reubi (1992)
10.1210/jcem-73-4-850
In vivo detection of somatostatin receptors in patients with functionless pituitary adenomas by means of a radioiodinated analog of somatostatin ([123I]SDZ 204-090).
G. Faglia (1991)
In vivo use of a radioiodinated somatostatin analogue: dynamics, metabolism, and binding to somatostatin receptor-positive tumors in man.
W. Bakker (1991)
Somatostatin receptor imaging with mIn-pentatreotide for whole body studies and high resolution brain SPECT
A VanDongen (1992)
10.1067/mhn.2000.102575
Octreotide scintigraphy for the detection of paragangliomas
F. Telischi (2000)
Colorectal cancer imaging with iodine-123-labeled CEA monoclonal antibody fragments.
D. Goldenberg (1993)
10.1111/j.1365-2141.1993.tb04634.x
Somatostatin analogue scintigraphy of malignant lymphomas
P. M. Vanhagen (1993)
Thyroid and orbital radiolabelled somatostatin accumulation in Graves' disease and Graves' ophthalmopathy
EP Ka-enning (1992)
Somatostatin treatment for pain in rheumatoid arthritis: a double blind versus placebo study in knee involvement
C Matucci (1988)
Distribution and biochemical characterization of somatostatin receptors in tumors of the human central nervous system.
J. Reubi (1987)
Receptor scintigraphy with a radioiodinated somatostatin analogue: radiolabeling, purification, biologic activity, and in vivo application in animals.
W. Bakker (1990)
Somatostatin receptor scintigraphy with mIn-pentatreotide in gastroenteropancreatic endocrine tumours (GEP)
V Ivancevic (1992)
10.1002/1097-0142(19801101)46:9<2116::AID-CNCR2820460934>3.0.CO;2-S
Familial carotid body tumors: Case report and epidemiologic review
S. Grufferman (1980)
10.2337/diab.30.2.127
Identification of Human Mononuclear Leukocytes Bearing Receptors for Somatostatin and Glucagon
S. Bhathena (1981)
10.1016/0016-5085(92)91505-X
Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue.
J. Reubi (1992)
Indium-lll-pentatreotide scintigraphy in detection of primary, recurrent and metastatic gastro-entero-pancreatic (GEP) endocrine tumours
S Pauwels (1992)
Novel clinical application of [ ~ 25 I - Tyr 3 ] - octreotide
AA Kafity (1991)
Imaging somatostatin receptor-positive neoplasms with 123I Tyr3-octreotide (TOCT) and rain [DTPA-D-Phel]-octreo tide (DOCT) somatostatin analogues
J Bomanji (1992)
10.1016/S0140-6736(89)91258-0
LOCALISATION OF ENDOCRINE-RELATED TUMOURS WITH RADIOIODINATED ANALOGUE OF SOMATOSTATIN
E. Krenning (1989)
10.1007/BF00169802
Somatostatin analogue scintigraphy in carcinoid tumours
D. Kwekkeboom (2004)
10.1111/j.1365-2265.1992.tb02276.x
Endocrine aspects of the diagnosis and treatment of primary brain tumours
Steven W. J. Lamberts (1992)
10.1002/ijc.2910460315
Somatostatin receptor incidence and distribution in breast cancer using receptor autoradiography: Relationship to egf receptors
J. Reubi (1990)
Coincidence of EGF receptors and somatostatin receptors in meningiomas but inverse, differentiation-dependent relationship in glial tumors.
J. Reubi (1989)
The clinical use of 131I-meta-iodobenzyl-guani dine (MIBG) for the diagnosis and treatment of neural crest tumours
CA Hoefnagel (1989)
10.1210/jcem-71-3-566
Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: consequences with regard to diagnosis, localization, and therapy.
S. Lamberts (1990)
Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin: 28.
A. O'carroll (1992)
10.1016/0169-5002(92)90142-7
Radioiodinated somatostatin analog scintigraphy in small-cell lung cancer.
D. Kwekkeboom (1991)
10.1055/s-2008-1062406
Rezeptorszintigraphie bei endokrinen gastroenteropankreatischen Tumoren
K. Joseph (1992)
10.1002/ijc.2910450211
Somatostatin receptors are present in small‐cell but not in non‐small‐cell primary lung carcinomas: Relationship to EGF‐receptors
J. Reubi (1990)
10.1056/NEJM199011013231805
Somatostatin-receptor imaging in the localization of endocrine tumors.
S. Lamberts (1990)
10.1159/000201082
In vitro detection of somatostatin receptors in human tumors.
J. Reubi (1992)
10.1210/jcem.76.6.8501144
In vivo somatostatin receptor imaging in medullary thyroid carcinoma.
D. Kwekkeboom (1993)
Somatostatin receptor imaging of endocrine gastrointestinal tumors.
E. Krenning (1992)
Molecular cloning and functional expression of a brain - specific somatostatin recep
Bruno Jf (1992)
10.1111/j.1365-2265.1993.tb01780.x
A case of antibody formation against octreotide visualized with 111In‐octreotide scintigraphy
D. Kwekkeboom (1993)
10.1016/0960-0760(92)90184-K
Somatostatin receptors in human cancer: Incidence, characteristics, functional correlates and clinical implications
J. Reubi (1992)
10.1210/mend.6.12.1337145
Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.
Y. Yamada (1992)
Effect of a long-acting somatostatin analogue (SMS 201-995) in patients with pancreatic cholera
PM Maton (1985)
Novel clinical application of [~25I-Tyr3]-octreotide. Fourth international congress on hormones and cancer; Amsterdam, 1991;abslr
AA Kafity (1993)
Somatostatin receptor scintigraphy with [mIn-DTPA-D-PHE~] octreotide in man: metabolism, dosimetry and comparison with [~23I-Tyr-3-]-octreotide
EP Krenning (1992)
In vitro and in vivo identification of somatostatin receptors in medullary thyroid carcinomas, phaeochromocytomas and paragangliomas
JC Reubi (1991)
10.1002/ijc.2910500613
in vitro and in vivo detection of somatostatin receptors in human malignant lymphomas
J. Reubi (1992)
10.1016/0889-1591(87)90019-5
Distribution of somatostatin receptors on murine spleen and Peyer's patch T and B lymphocytes
R. Scicchitano (1987)



This paper is referenced by
10.1093/ajcn/nqy324
Attenuation of satiety gut hormones increases appetitive behavior after curative esophagectomy for esophageal cancer.
Jessie A. Elliott (2019)
10.1210/jc.2010-2022
Performance of (18)fluorodeoxyglucose-positron emission tomography and somatostatin receptor scintigraphy for high Ki67 (≥10%) well-differentiated endocrine carcinoma staging.
Ronan Abgral (2011)
10.1016/j.apradiso.2013.01.039
Clinical applications of Gallium-68.
S. Banerjee (2013)
10.1097/MNM.0000000000000239
Contribution of 111In-pentetreotide SPECT/CT imaging to conventional somatostatin receptor scintigraphy in the detection of neuroendocrine tumours
A. Sainz-Esteban (2015)
10.2217/ije-2017-0018
Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.
D. Metz (2017)
10.1055/S-0042-124064
Moderne Diagnosekonzepte für gastroenteropankreatische NET
Andreas Pfestroff (2017)
10.1007/BF03044730
Die multiple endokrine Neoplasie Typ I
R. Lamberts (2009)
10.1002/cncr.11473
Prospective study of the ability of serial measurements of serum chromogranin A and gastrin to detect changes in tumor burden in patients with gastrinomas
A. Abou-Saif (2003)
10.1007/s40336-013-0043-x
Multiagent targeting of neuroendocrine neoplasms
D. Volterrani (2013)
10.1016/j.ymeth.2009.03.012
Molecular imaging targeting peptide receptors.
M. Schottelius (2009)
10.3171/FOC.2007.23.3.2
Diagnostic approach to Cushing disease.
B. Gross (2007)
Bombesin and Neurotensin Receptor Targeting Using Radiolabeled Peptide Analogs
M. Visser (2007)
10.1007/s12149-007-0085-0
Nonfunctioning endocrine pancreatic tumor examined with 18F-FDG PET/CT
N. Toshikuni (2008)
10.2967/jnumed.114.153189
Triple-Peptide Receptor Targeting In Vitro Allows Detection of All Tested Gut and Bronchial NETs
J. Reubi (2015)
10.1007/978-3-662-45215-8_9
Nuclear Medicine Imaging in Neuroendocrine Tumors
A. Kjaer (2015)
10.1053/j.semnuclmed.2011.02.002
The next generation of positron emission tomography radiopharmaceuticals in oncology.
Samuel L Rice (2011)
10.1016/J.BEEM.2006.12.003
Nuclear imaging of neuroendocrine tumours.
A. Sundin (2007)
10.1016/S1155-1976(07)22883-9
Somatostatine en pathologie tumorale pancréatique
D. Vezzosi (2007)
10.1210/JC.2006-0825
99mTc-depreotide scintigraphy versus 18F-FDG-PET in the diagnosis of radioiodine-negative thyroid cancer.
M. Rodrigues (2006)
10.1097/00003072-200204000-00019
Parathyroid adenoma visualization on octreotide scintigraphy.
H. Boulahdour (2002)
10.1038/sj.bjc.6602845
Successful receptor-mediated radiation therapy of xenografted human midgut carcinoid tumour
L. Kölby (2005)
10.2165/00063030-200519030-00002
Radiolabeled Peptides in Oncology
R. Weiner (2012)
10.1089/108497804773391702
99mTc-N4-[Tyr3]Octreotate Versus 99mTc-EDDA/HYNIC-[Tyr3]Octreotide: an intrapatient comparison of two novel Technetium-99m labeled tracers for somatostatin receptor scintigraphy.
M. Gabriel (2004)
10.1039/C1NJ20416E
Dendrimers in nuclear medical imaging
C. Ghobril (2012)
Long-term efficacy of radionuclide therapy in patients with disseminated neuroendocrine tumors uncontrolled by conventional therapy.
C. Nguyen (2004)
10.1007/s00761-004-0717-0
Bildgebung bei neuroendokrinen Tumoren
H. Amthauer (2004)
Evaluation of [99mTc/EDDA/HYNIC0]octreotide derivatives compared with [111In-DOTA0,Tyr3, Thr8]octreotide and [111In-DTPA0]octreotide: does tumor or pancreas uptake correlate with the rate of internalization?
D. Storch (2005)
10.2310/7290.2006.00001
Permeation Peptide Conjugates for In Vivo Molecular Imaging Applications
K. Bullok (2006)
10.1056/NEJMoa1607427
Phase 3 Trial of 177Lu‐Dotatate for Midgut Neuroendocrine Tumors
J. Strosberg (2017)
10.1245/s10434-014-3981-2
Impact of 68Ga-DOTATATE PET/CT on the Surgical Management of Primary Neuroendocrine Tumors of the Pancreas or Ileum
H. Ilhan (2014)
10.1016/S1575-0922(02)74483-5
Utilidad de la ultrasonografía endoscópica (USE) en la evaluación prequirúrgica de los tumores neuroendocrinos
L. Argüello (2002)
Labelling of Various Macromolecules Using Positron Emitting 76 Br and 68 Ga Synthesis and Characterisation BY ULRIKA YNGVE ACTA UNIVERSITATIS UPSALIENSIS UPPSALA 2001
Till Jonas (2001)
See more
Semantic Scholar Logo Some data provided by SemanticScholar