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Mitochondrial Abnormalities In The Postviral Fatigue Syndrome
W. Behan, I. More, P. Behan
Published 2004 · Biology, Medicine
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SummaryWe have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed branching and fusion of mitochondrial cristae. Mitochondrial degeneration was obvious in 40 of the biopsies with swelling, vacuolation, myelin figures and secondary lysosomes. These abnormalities were in obvious contrast to control biopsies, where even mild changes were rarely detected. The findings described here provide the first evidence that PFS may be due to a mitochondrial disorder precipitated by a virus infection.
This paper references
Epidemic neuromyasthenia; clinical syndrome.
D. A. Henderson (1959)
Epidemic Neuro. myasthenia-Clinical Syndromeγ.
D. Henderson (1959)
The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia.
E. Acheson (1959)
Shelokov A (1959) Epidemic neuromyasthenia: clinical syndrome
DA Henderson (1959)
Encephalomyelitis resembling benign myalgic encephalomyelitis.
S. Innes (1970)
Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera).
J. Partin (1971)
Epidemic Neuromyasthenia: Outbreak among Nurses at a Children's Hospital
M. Dillon (1974)
Effects of viral and mycoplasma infections on ultrastructure and enzyme activities in human skeletal muscle.
E. Åström (1976)
Hepatitis-associated lipid storage myopathy.
B. Patten (1977)
Neuromuscular disorders with abnormal muscle mitochondria.
Z. Kamieniecka (1980)
The function of muscle mitochondria
JH Veerkamp (1981)
Mitochondrial encephalomyopathies: biochemical studies in two cases revealing defects in the respiratory chain.
J. Morganhughes (1982)
Mitochondrial encephalopathies. Biochemical studies in two cases revealing defects in the respiratory
JA Morgan-Hughes (1982)
Pathological reactions of skeietal muscle
M JCullen (1982)
Myalgic encephalomyelitis--report of an epidemic.
K. G. Fegan (1983)
Molecular genetics, pseudogenetics, and clinical neurology
L. Rowland (1983)
EXCESSIVE INTRACELLULAR ACIDOSIS OF SKELETAL MUSCLE ON EXERCISE IN A PATIENT WITH A POST-VIRAL EXHAUSTION/FATIGUE SYNDROME A 31P Nuclear Magnetic Resonance Study
D. Arnold (1984)
Mitochondrial respiratory chain deficiencies in man . Some histochemical and fine - structural observations
JA Morgan-Hughes (1984)
Mitochondrial respiratory chain deficiencies in man. Some histochemical and fine-structural observations. In: Serratrice G, et al (eds) Neuromuscular diseases
JA Morgan-Hughes (1984)
Electrophysiological studies in the post-viral fatigue syndrome.
G. Jamal (1985)
Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.
E. Byrne (1985)
Eye motility dysfunction in chronic primary fibromyalgia with dysesthesia.
U. Rosenhall (1987)
Coxsackie B viruses and the post-viral syndrome: a prospective study in general practice.
B. J. Calder (1987)
Neuroaudiological findings in chronic primary fibromyalgia with dysesthesia.
U. Rosenhall (1987)
( b ) Neuroau - diological findings in chronic primary fibromyalgia with dyses - thesia
U Rosenhall (1987)
Chronic fatigue syndrome: a working case definition.
G. Holmes (1988)
Postviral fatigue syndrome.
P. O. Behan (1988)
Ultrastructural pathology of the cell and matrix
F. N. Ghadially (1988)
Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase
L. Archard (1988)
Detection of Epstein-Barr virus DNA in muscle from patients with postviral chronic fatigue syndrome, myalgic encephalomyelitis
LC Archard (1988)
Post-viral fatigue syndrome: evidence for underlying organic disturbance in the muscle fibre.
G. Jamal (1989)
Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome.
C. Moraes (1989)
A. Schapira (1989)
Antibody to Coxsackie B virus in diagnosing postviral fatigue syndrome.
Naomi A. Miller (1991)
Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome.
J. Gow (1991)
The occurrence of paracrystalline mitochondrial inclusions in normal human skeletal muscle
F. Hammersen (2004)
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Adam J. O'Neal (2021)
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Guanyu Lu (2021)
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S. Poenaru (2021)
The Invisible Rainbow: A History of Electricity and Life
A. Firstenberg (2020)
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G. Anderson (2020)
Chronic Fatigue Syndrome
J. Nowicki (2020)
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S. Holden (2020)
Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
E. Wood (2020)
Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
A. Gusnanto (2020)
Modification of Immunological Parameters, Oxidative Stress Markers, Mood Symptoms, and Well-Being Status in CFS Patients after Probiotic Intake: Observations from a Pilot Study
L. Venturini (2019)
Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Daniel Missailidis (2019)
Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types
Cara Tomas (2019)
Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review.
Kholoud M El-Shewy (2019)
Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research
A. Rusin (2018)
Epidemiological, pathological and metabolomic characterisation of an acquired myopathy of dogs in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science at Massey University, Manawatū, New Zealand
Hayley Hunt (2018)
Myalgic encephalomyelitis: International Consensus Criteria
B. M. Carruthers (2017)
Chronic Fatigue Syndrome, Functional Mitochondriopathy, and Enterohepatic Dysfunction.
J. Bland (2017)
Skeletal muscle fatigue : investigating the role of cytokines, ROS and mitochondrial function
K. Earl (2016)
The Application of the International Consensus Criteria to Assess Prevalence of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis in Australia
S. Johnston (2016)
Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
W. Mitchell (2016)
Investigating the biochemical basis of muscle cell dysfunction in chronic fatigue syndrome
G. Rutherford (2016)
Fibromyalgia and Bipolar Disorder: Emerging Epidemiological Associations and Shared Pathophysiology.
B. Bortolato (2016)
Evaluating the involvement of mtDNA variants in patients diagnosed with myalgic encephalomyelitis
V. Dyk (2016)
Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an evidence-based approach to diagnosis and management by clinicians
A. Bested (2015)
A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome.
J. Kaiser (2015)
Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?
R. Boles (2015)
The 4I Hypothesis: A Neuro-Immunological Explanation for Characteristic Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Frank N M Twisk (2015)
Original Article A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome
Jon D. Kaiser (2015)
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
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