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Mitochondrial Abnormalities In The Postviral Fatigue Syndrome

W. Behan, I. More, P. Behan
Published 2004 · Biology, Medicine

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SummaryWe have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed branching and fusion of mitochondrial cristae. Mitochondrial degeneration was obvious in 40 of the biopsies with swelling, vacuolation, myelin figures and secondary lysosomes. These abnormalities were in obvious contrast to control biopsies, where even mild changes were rarely detected. The findings described here provide the first evidence that PFS may be due to a mitochondrial disorder precipitated by a virus infection.
This paper references
10.1056/NEJM195904092601506
Epidemic neuromyasthenia; clinical syndrome.
D. A. Henderson (1959)
Epidemic Neuro. myasthenia-Clinical Syndromeγ.
D. Henderson (1959)
10.1016/0002-9343(59)90280-3
The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia.
E. Acheson (1959)
Shelokov A (1959) Epidemic neuromyasthenia: clinical syndrome
DA Henderson (1959)
10.1016/S0140-6736(70)91097-4
Encephalomyelitis resembling benign myalgic encephalomyelitis.
S. Innes (1970)
10.1056/NEJM197112092852402
Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera).
J. Partin (1971)
10.1136/bmj.1.5903.301
Epidemic Neuromyasthenia: Outbreak among Nurses at a Children's Hospital
M. Dillon (1974)
10.1111/J.1699-0463.1976.TB00080.X
Effects of viral and mycoplasma infections on ultrastructure and enzyme activities in human skeletal muscle.
E. Åström (1976)
10.7326/0003-4819-87-4-417
Hepatitis-associated lipid storage myopathy.
B. Patten (1977)
10.1016/S0074-7696(08)61964-6
Neuromuscular disorders with abnormal muscle mitochondria.
Z. Kamieniecka (1980)
The function of muscle mitochondria
JH Veerkamp (1981)
10.1093/BRAIN/105.3.553
Mitochondrial encephalomyopathies: biochemical studies in two cases revealing defects in the respiratory chain.
J. Morganhughes (1982)
Mitochondrial encephalopathies. Biochemical studies in two cases revealing defects in the respiratory
JA Morgan-Hughes (1982)
Pathological reactions of skeietal muscle
M JCullen (1982)
Myalgic encephalomyelitis--report of an epidemic.
K. G. Fegan (1983)
10.1212/WNL.33.9.1179
Molecular genetics, pseudogenetics, and clinical neurology
L. Rowland (1983)
10.1016/S0140-6736(84)91871-3
EXCESSIVE INTRACELLULAR ACIDOSIS OF SKELETAL MUSCLE ON EXERCISE IN A PATIENT WITH A POST-VIRAL EXHAUSTION/FATIGUE SYNDROME A 31P Nuclear Magnetic Resonance Study
D. Arnold (1984)
Mitochondrial respiratory chain deficiencies in man . Some histochemical and fine - structural observations
JA Morgan-Hughes (1984)
Mitochondrial respiratory chain deficiencies in man. Some histochemical and fine-structural observations. In: Serratrice G, et al (eds) Neuromuscular diseases
JA Morgan-Hughes (1984)
10.1136/jnnp.48.7.691
Electrophysiological studies in the post-viral fatigue syndrome.
G. Jamal (1985)
10.1111/J.1445-5994.1985.TB04042.X
Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.
E. Byrne (1985)
Eye motility dysfunction in chronic primary fibromyalgia with dysesthesia.
U. Rosenhall (1987)
Coxsackie B viruses and the post-viral syndrome: a prospective study in general practice.
B. J. Calder (1987)
Neuroaudiological findings in chronic primary fibromyalgia with dysesthesia.
U. Rosenhall (1987)
( b ) Neuroau - diological findings in chronic primary fibromyalgia with dyses - thesia
U Rosenhall (1987)
10.7326/0003-4819-108-3-387
Chronic fatigue syndrome: a working case definition.
G. Holmes (1988)
Postviral fatigue syndrome.
P. O. Behan (1988)
Ultrastructural pathology of the cell and matrix
F. N. Ghadially (1988)
10.1177/014107688808100608
Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase
L. Archard (1988)
Detection of Epstein-Barr virus DNA in muscle from patients with postviral chronic fatigue syndrome, myalgic encephalomyelitis
LC Archard (1988)
10.1159/000116426
Post-viral fatigue syndrome: evidence for underlying organic disturbance in the muscle fibre.
G. Jamal (1989)
10.1056/NEJM198905183202001
Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome.
C. Moraes (1989)
10.1142/9781848161665_0019
Mitochondrial myopathies.
A. Schapira (1989)
10.1136/bmj.302.6769.140
Antibody to Coxsackie B virus in diagnosing postviral fatigue syndrome.
Naomi A. Miller (1991)
10.1136/bmj.302.6778.692
Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome.
J. Gow (1991)
10.1007/BF00692217
The occurrence of paracrystalline mitochondrial inclusions in normal human skeletal muscle
F. Hammersen (2004)



This paper is referenced by
10.3389/fmed.2021.688486
The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review
Adam J. O'Neal (2021)
10.1073/pnas.2024358118
Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
B. Paul (2021)
NDT_A_317027 2063..2071
Elanwar (2021)
10.2147/NDT.S317027
Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study
Rehab Elanwar (2021)
10.3390/foods10051030
Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review
Guanyu Lu (2021)
10.1177/20499361211009385
COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review
S. Poenaru (2021)
The Invisible Rainbow: A History of Electricity and Life
A. Firstenberg (2020)
10.1016/j.pnpbp.2020.109976
Mitochondria and immunity in chronic fatigue syndrome
G. Anderson (2020)
10.1016/B978-0-323-43044-9.00160-6
Chronic Fatigue Syndrome
J. Nowicki (2020)
10.1186/s12967-020-02452-3
A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease
S. Holden (2020)
10.1016/j.cdtm.2020.11.002
Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’?
E. Wood (2020)
10.1101/2020.08.17.20164715
Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
A. Gusnanto (2020)
10.1155/2019/1684198
Modification of Immunological Parameters, Oxidative Stress Markers, Mood Symptoms, and Well-Being Status in CFS Patients after Probiotic Intake: Observations from a Pilot Study
L. Venturini (2019)
10.3390/diagnostics9030080
Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Daniel Missailidis (2019)
10.7717/peerj.6500
Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types
Cara Tomas (2019)
10.1016/j.biopha.2018.10.157
Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review.
Kholoud M El-Shewy (2019)
10.1080/09553002.2018.1422871
Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research
A. Rusin (2018)
Epidemiological, pathological and metabolomic characterisation of an acquired myopathy of dogs in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science at Massey University, Manawatū, New Zealand
Hayley Hunt (2018)
10.1111/joim.12658
Myalgic encephalomyelitis: International Consensus Criteria
B. M. Carruthers (2017)
Chronic Fatigue Syndrome, Functional Mitochondriopathy, and Enterohepatic Dysfunction.
J. Bland (2017)
10.17638/03001668
Skeletal muscle fatigue : investigating the role of cytokines, ROS and mitochondrial function
K. Earl (2016)
The Application of the International Consensus Criteria to Assess Prevalence of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis in Australia
S. Johnston (2016)
10.1586/17512433.2016.1172960
Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
W. Mitchell (2016)
Investigating the biochemical basis of muscle cell dysfunction in chronic fatigue syndrome
G. Rutherford (2016)
10.2174/1566524016666160126144027
Fibromyalgia and Bipolar Disorder: Emerging Epidemiological Associations and Shared Pathophysiology.
B. Bortolato (2016)
Evaluating the involvement of mtDNA variants in patients diagnosed with myalgic encephalomyelitis
V. Dyk (2016)
10.1515/reveh-2015-0026
Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an evidence-based approach to diagnosis and management by clinicians
A. Bested (2015)
A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome.
J. Kaiser (2015)
10.1016/j.mito.2015.04.005
Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?
R. Boles (2015)
10.17554/j.issn.2313-5611.2015.01.13
The 4I Hypothesis: A Neuro-Immunological Explanation for Characteristic Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Frank N M Twisk (2015)
Original Article A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome
Jon D. Kaiser (2015)
10.1186/s12916-015-0310-y
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
G. Morris (2015)
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