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Nonuniform Size Distribution Of Nascent Globin Peptides, Evidence For Pause Localization Sites, And A Cotranslational Protein-folding Model

I. Krasheninnikov, A. A. Komar, I. Adzhubei
Published 1991 · Chemistry, Medicine

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Examination of nascent globin peptides accumulatingin vitro during globin synthesis in rabbit reticulocyte lysates was carried out. A view was supported that nonrandom distribution of codons with different usage frequencies in mRNA may determine the messenger's translation kinetics. Regions of reduced translation of α- and β-globin polypeptide chains were localized, and the cotranslational protein-folding model suggested previously was substantiated. An active conjunction of synthesis and folding of proteins was proposed as one of the main destinations of a translation nonuniformity.
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