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Eosinophil Cationic Protein In Atopic Eczema

T. Jakob, K. Hermann, J. Ring
Published 2005 · Medicine

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Atopic eczema (AE) is frequently associated with peripheral blood eosinophilia [2]. Increased serum levels of the eosinophil granule major basic protein (MBP) [8], dermal deposition of MBP in skin lesions [5], and a cutaneous eosinophil infiltration after patch testing have been reported in patients with AE [1], indicating that eosinophils may play a role in the pathogenesis of AE. Here we evaluate the serum levels of another eosinophil product, the eosinophil cationic protein (ECP) in patients with AE, in patients with respiratory atopy and in non-atopic healthy volunteers. AE patients were subdivided into three groups, using the estimated extent of body surface involvement (according to the "rule of nine") and the intensity of eczematous lesions as criteria for classification according to the following scheme:
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