Online citations, reference lists, and bibliographies.
← Back to Search

Antigen-Specific T-cell Factors In The Immune Response To Poly(Tyr,Glu)-poly(Pro)-poly(Lys)

R. Isac, E. Mozes, M. Taussig
Published 2005 · Biology

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The production by T cells of an antigen-specific factor capable of replacing the T-cell function in specific antibody formation was used as a tool for studying the cellular aspects of the genetic control of immune responses. The ability of different T-cell populations to produce a cooperative signal and the ability of B-cell populations to react to this signal were studied in different mouse strains. The antigen used was the synthetic polypeptide poly(LTyr,LGlu)-poly-(LPro) —poly(lXys), (T,G)-Pro -L, the response to which was found not to beH-2-linked. It was found that the SWR strain of mice, a low responder to (T,G)-Pro -L, is not capable of producing a T-cell factor specific to this antigen, but its B cells react normally to an active factor produced in a high responder strain. In the DBA/1 strain, also a low responder to (T,G)-Pro -L, the bone marrow cells are not able to cooperate with an active T-cell factor to produce anti-(T,G)-Pro —L-specific antibodies, while their T cells do produce a (T,G)-Pro -L-specific factor. The SWR (low responder) B cells can be triggered by DBA/1 (low responder) T cells factor specific to (T,G)-Pro —L to produce an antibody response to this immunogen. These results suggest that the immune response to (T,G)-Pro -L is controlled by two genes which are expressed in different lymphocyte populations.
This paper references
10.1126/SCIENCE.140.3565.405
Plaque Formation in Agar by Single Antibody-Producing Cells
N. K. Jerne (1963)
10.1042/BJ0930566
Antigenicity of some new synthetic polypeptides and polypeptidyl gelatins.
S. Fuchs (1964)
Role of optical configuration in the immunogenicity and specificity of synthetic antigens derived from multichain polyproline.
J. Jaton (1968)
10.1084/JEM.130.3.493
THE NATURE OF THE ANTIGENIC DETERMINANT IN A GENETIC CONTROL OF THE ANTIBODY RESPONSE
E. Mozes (1969)
10.1084/JEM.130.6.1263
THE GENETIC CONTROL OF ANTIBODY SPECIFICITY
E. Mozes (1969)
10.1007/978-3-642-65444-2_6
Genetic control of immune responses.
E. Mozes (1972)
10.1084/JEM.135.5.1009
CONTRIBUTION OF DIFFERENT CELL TYPES TO THE GENETIC CONTROL OF IMMUNE RESPONSES AS A FUNCTION OF THE CHEMICAL NATURE OF THE POLYMERIC SIDE CHAINS (POLY-L-PROLYL AND POLY-DL-ALANYL) OF SYNTHETIC IMMUNOGENS
G. Shearer (1972)
Passive hemagglutination with special reference to the tanned cell technique
W. J. Herbert (1973)
10.1084/JEM.140.2.301
ANTIGEN-SPECIFIC THYMUS CELL FACTORS IN THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO POLY-(TYROSYL, GLUTAMYL)-POLY-D, L-ALANYL--POLY-LYSYL
M. Taussig (1974)
10.1038/248234A0
T cell factor which can replace T cells in vivo
M. Taussig (1974)
10.1016/0019-2791(74)90187-6
Immunological unresponsiveness induced in adult mice to synthetic polypeptides built on multichain polyproline and multichain polyalanine.
B. Bonavida (1974)
10.1073/PNAS.71.4.1574
The role of the thymus in a genetically controlled defect of the immune response at the carrier level.
E. Mozes (1974)
10.1084/JEM.140.6.1579
ANTIGEN-SPECIFIC T-CELL FACTOR IN CELL COOPERATION: PHYSICAL PROPERTIES AND MAPPING IN THE LEFT-HAND (K) HALF OF H-2
A. Munro (1974)
Antigen - specific thymus cell factors in the genetic control of the immune response to ( T , G ) - A - L
M. J. Taussig (1974)
10.1126/SCIENCE.175.4019.273
The histocompatibility-linked immune response genes.
B. Benacerraf (1975)
10.1084/JEM.142.3.694
Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers
M. Taussig (1975)
10.1084/JEM.141.3.703
Antigen-specific T-cell factors in the genetic control of the immune response to poly(Tyr,Glu)-polyDLAla--polyLys. Evidence for T- and B- cell defects in SJL mice
E. Mozes (1975)
10.1038/256103A0
Two genes in the major histocompatibility complex control immune response
A. Munro (1975)
10.1016/B978-0-12-401660-6.50041-2
THE NATURE OF ANTIGEN SPECIFIC T CELL FACTORS INVOLVED IN THE GENETIC REGULATION OF IMMUNE RESPONSES
E. Mozes (1976)
10.1007/978-1-4613-4355-4_85
Antigen specific T cell factors in the genetic control of the immune response to poly(tyr,glu)poly(pro)--poly(lys).
E. Mozes (1976)
10.1111/j.1600-065X.1984.tb00496.x
Immunological Unresponsiveness Induced by Ultraviolet Radiation
M. Kripke (1984)
10.1007/BF01572311
Expression of immune response (Ir) genes in T and B cells
E. Mozes (2005)
10.1007/BF01564042
Genetic control of immune responses
I. Green (2005)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar