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Body Size, Estrogen Use And Thiazide Diuretic Use Affect 5-year Radial Bone Loss In Postmenopausal Women

M. Sowers, M. K. Clark, M. Jannausch, R. Wallace
Published 2005 · Medicine

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Understanding factors associated with more rapid bone mineral loss among aging women is important for establishing preventive strategies for intervention. This study reports factors associated with the 5-year change in radial bone mineral density (BMD) determined prospectively in 435 women aged 55–80 years at baseline. The baseline study included measurement of radial BMD (gm/cm2) by single photon densitometry and personal interview. The baseline protocol was replicated 5 years later in a follow-up study. Women with a lower baseline weight or Quetelet index, smaller triceps skinfold and less arm muscle area had significantly greater 5-year bone loss (p=0.001). Current users of estrogens had less radial bone loss (2.8% vs 7.3%,p=0.0005) than women not currently using estrogens. Current users of estrogen had significantly less 5-year loss if use had been for 5 years or longer (−1.0% vs −6.9%,p=0.05). Current users of the thiazide class of medications had less 5-year radial bone loss (5.0% vs 7.4%,p=0.0035) than women without current thiazide use. Baseline dietary calcium, alcohol consumption and smoking were not associated with BMD change. This suggests that greater body size, and current use of estrogens or thiazide antihypertensives are associated with less radial bone mass loss in a 5-year period among postmenopausal women.
This paper references
Role of extraglandular estrogen in human endocrinology
PK Siiteri
10.2106/00004623-198466070-00007
Bone loss in premenopausal and postmenopausal women. A cross-sectional and longitudinal study using quantitative computed tomography.
P. Ruegsegger (1984)
10.1093/ajcn/41.5.1045
Correlates of mid-radius bone density among postmenopausal women: a community study.
M. Sowers (1985)
10.1093/oxfordjournals.aje.a113974
Effects of intraindividual and interindividual variation in repeated dietary records.
C. Sempos (1985)
10.1016/0020-7292(91)90314-U
A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women.
B. Dawson-Hughes (1990)
10.1016/0021-9681(82)90095-9
A prospective study of change in bone mass with age in postmenopausal women.
S. Hui (1982)
10.1016/0020-7292(91)90647-N
Estrogen Treatment of Patients With Established Postmenopausal Osteoporosis
R. Lindsay (1990)
10.2307/3150614
Applied Regression Analysis and Other Multivariable Methods
D. Kleinbaum (1978)
10.1056/NEJM198308113090605
Thiazide effect on the mineral content of bone.
R. Wasnich (1983)
10.1007/BF02556373
Prospective study of radial bone mineral density in a geographically defined population of postmenopausal Caucasian women
M. Sowers (2007)
10.1016/8756-3282(87)90062-7
Obesity and postmenopausal bone loss: the influence of obesity on vertebral density and bone turnover in postmenopausal women.
C. Ribot (1987)
10.1093/ajcn/44.6.889
The relationship of bone mass and fracture history to fluoride and calcium intake: a study of three communities.
M. Sowers (1986)
10.1016/8756-3282(90)90138-O
Perimenopausal appendicular bone loss: a 10-year prospective study.
J. Falch (1990)
Sex steroids in the pathogenesis and prevention of osteoporosis
R Lindsey (1988)
10.1016/0026-0495(82)90115-9
Thiazide for the postponement of postmenopausal bone loss.
I. Transbøl (1982)
10.1002/JBMR.5650040309
Comparison of cross-sectional and longitudinal measurements of age-related changes in bone mineral content.
J. Davis (1989)
10.7326/0003-4819-66-5-917
The absorption of calcium carbonate.
P. Ivanovich (1967)
10.1007/BF01624144
Do current regimes of hormone replacement therapy protect against subsequent fractures?
T. Spector (2005)
10.1097/00006254-199305000-00025
Increase in bone mass after one year of percutaneous oestradiol and testosterone implants in post-menopausal women who have previously received long-term oral oestrogens.
M. Savvas (1992)
10.1093/oxfordjournals.aje.a114416
A data-based approach to diet questionnaire design and testing.
G. Block (1986)
10.1056/NEJM199208273270908
The prevention and treatment of osteoporosis.
B. Riggs (1992)
10.1007/BF02555919
Calcium intake and bone mass: A quantitative review of the evidence
R. Cumming (2007)
[Epidemiology of fractures].
M. Isnard (1995)



This paper is referenced by
10.1001/JAMA.298.2.179
Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials.
P. Conway (2007)
10.1016/B978-012370544-0.50036-7
CHAPTER 34 – Nonskeletal Risk Factors for Osteoporosis and Fractures
J. Nieves (2008)
10.2165/11538200-000000000-00000
Treatment with Fall-Risk-Increasing and Fracture-Preventing Drugs Before and After a Hip Fracture
Christina Sjöberg (2010)
10.1007/s00198-004-1745-8
Reducing the risk for distal forearm fracture: preserve bone mass, slow down, and don’t fall!
J. Kelsey (2004)
10.1016/J.JACC.2005.03.055
Diuretics and bone loss in rats with aldosteronism.
Peter H Law (2005)
10.5278/vbn.phd.med.00101
Thiazide diuretics and hyponatremia in relation to osteoporosis
Christian Kruse (2017)
10.1201/b11228-26
Obesity, adipose tissue, and bone
Sue A Shapses (2016)
10.1007/s00223-012-9671-9
The Relationship Among Hypertension, Antihypertensive Medications, and Osteoporosis: A Narrative Review
Katarina Ilić (2012)
10.1159/000106478
The Complexity of Age-Related Hearing Impairment: Contributing Environmental and Genetic Factors
E. Van Eyken (2007)
10.1097/SMJ.0b013e318167d5f3
Thiazides and Osteoporosis: An Addition to the Armamentarium?
R. Hamdy (2008)
10.1016/S8756-3282(03)00237-0
Adiponectin as a novel determinant of bone mineral density and visceral fat.
L. Lenchik (2003)
10.1016/B978-0-12-415853-5.00034-0
Nonskeletal Risk Factors for Osteoporosis and Fractures
Jeri W. Nieves (2013)
10.1046/J.1532-5415.2003.51107.X
Effect of low-dose thiazide diuretics on plasma lipids: results from a double-blind, randomized clinical trial in older men and women.
S. Ott (2003)
10.1159/000106478
The Complexity of Age-Related Hearing Impairment: Contributing Environmental and Genetic Factors
E. V. Eyken (2007)
iuretics and Bone Loss in Rats With Aldosteronism eter
Humanitarian Law (2016)
10.1210/jc.2019-00111
Dietary calcium intake and bone loss over 6 years in osteopenic postmenopausal women.
Sarah M Bristow (2019)
10.1007/BF01623465
A prospective study of thiazide use and fractures in women
Dr D. Feskanich (2005)
Bone mineral density loss in women who initiated antihypertensive medications during the menopausal transition in a multicenter, multiethnic, community-based cohort study: women's health across the nation (SWAN)
Zhenping Zhao (2014)
10.1158/1055-9965.EPI-08-0936
Risk of Endometrial Cancer in Relation to Medical Conditions and Medication Use
J. Fortuny (2009)
10.1007/s00198-005-1851-2
Role of chronic health disorders in perimenopausal fractures
J. Huopio (2005)
10.1007/BF02390832
A meta-analysis of the effects of cigarette smoking on bone mineral density
K. Ward (2006)
A comparative study of the determinants of bonestrength and the propensity to falls in black andwhite South African women
M. Conradie (2008)
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