Online citations, reference lists, and bibliographies.
← Back to Search

Neuroeffector Functions Of Sensory Fibres: Implications For Headache Mechanisms And Drug Actions

M. Moskowitz, M. G. Buzzi
Published 2004 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
SummaryThe results of recent investigations designed to elucidate the neuroeffector functions of sensory fibres, the cause of migraine headache and the mechanism of action of antimigraine drugs are reviewed and discussed. Neurogenic inflammation (vasodilatation and neurogenic plasma extravasation) is one explanation for the development of headaches and the blood flow changes which occur during migraine headache. Numerous studies have recently been carried out on rats and guinea-pigs into the effects of antimigraine agents, including ergot alkaloids, sumatriptan and non-steroidal anti-inflammatory drugs (NSAIDs), on neurogenic plasma protein extravasation in the dura mater induced by electrical stimulation of trigeminal ganglia or systemic administration of capsaicin. It is known that the dura mater is able to produce headaches in man. Ergot alkaloids have been shown to block neurogenic inflammation via a C-fibre dependent neuronal mechanism. Sumatriptan appears to act fairly similarly although, whereas the ergot alkaloids are non-selective for either 5-hydroxytryptamine (5-HT; serotonin) receptors or 5-HT1, sumatriptan is selective for 5-HT1 receptors. The antimigraine action of NSAIDs may be via either an effect on blood vessels or an effect on the nerve fibre. The antimigraine effects of ergot alkaloids, sumatriptan and NSAIDs are discussed in the light of the common vasoconstrictor actions of these agents and knowledge that vasodilatation is apparently not responsible for migraine headache pain in most cases.
This paper references
Mechanisms of cluster headache. In: Otesen J, Edvinsson L (eds) Basic mechanisms of headache
K Ekbom (1988)
10.1111/J.1748-1716.1982.TB07116.X
Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea.
J. M. Lundberg (1982)
10.1177/0333102489009S10186
Dose Reponse Study for Subcutaneous GR43175 in the Treatment of Acute Migraine
J. Byer (1989)
10.1016/0014-2999(89)90406-8
Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites.
S. Peroutka (1989)
Morphological effects of electrical trigeminal ganglion stimulation (ETG) on intra- and extracranial vessels
MG Buzzi (1990)
10.1016/0028-3908(91)90165-8
Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion
M. G. Buzzi (1991)
Untersuchungen fiber die GeffignervenWurzeln des Ischiadicus
S Stricker (1876)
10.3171/JNS.1974.40.2.0143
Controlled thermocoagulation of trigeminal ganglion and rootlets for differential destruction of pain fibers: facial pain other than trigeminal neuralgia.
W. Sweet (1976)
10.1111/j.1365-2133.1984.tb06624.x
The role of Substance P in the axon reflex in the rat
P. Kenins (1984)
10.1177/0333102489009S10187
Oral GR43175, A 5HT1-Like Agonist, for Treatment of the Acute Migraine Attack: An International Study - Preliminary Results
C. Dahlöf (1989)
10.1016/0014-2999(89)90719-X
Indomethacin and acetylsalicylic acid block neurogenic plasma protein extravasation in rat dura mater.
M. G. Buzzi (1989)
10.1111/J.1748-1716.1984.TB00127.X
Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig.
J. M. Lundberg (1984)
10.1111/j.1476-5381.1990.tb14679.x
The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater
M. G. Buzzi (1990)
10.1001/ARCHSURG.1940.01210040002001
EXPERIMENTAL STUDIES ON HEADACHE: PAIN-SENSITIVE STRUCTURES OF THE HEAD AND THEIR SIGNIFICANCE IN HEADACHE
B. S. Ray (1940)
10.1111/j.1476-5381.1989.tb11787.x
The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs
W. Feniuk (1989)
10.1111/j.1526-4610.1989.hed2907420.x
Comparative Neuropharmacology of Dihydroergotamine and Sumatriptan (GR 43175)
B. G. McCarthy (1989)
10.1007/BF00503897
Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge
A. Saria (2004)
10.1016/S0140-6736(88)92122-8
POSSIBLE BENEFIT OF GR43175, A NOVEL 5-HT1-LIKE RECEPTOR AGONIST, FOR THE ACUTE TREATMENT OF SEVERE MIGRAINE
A. Doenicke (1988)
10.1016/0304-3959(75)90026-3
Controlled thermocoagulation of trigeminal ganglion and rootles for differential destruction of pain fibers; 1: trigeminal neuralgia
W. Sweet (1974)
10.1007/BF00500282
Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
F. Lembeck (2004)
10.1152/AJPHEART.1989.257.5.H1736
Postocclusive cerebral hyperemia is markedly attenuated by chronic trigeminal ganglionectomy.
M. Moskowitz (1989)
10.1016/0306-4522(86)90024-2
Capsaicin induced release of multiple tachykinins (substance P, neurokinin A and eledoisin-like material) from guinea-pig spinal cord and ureter
X. Hua (1986)
The nocifensor system of nerves and its reaction
T Lewis (1937)
10.1002/CNE.903020422
Preproenkephalin upregulation in nucleus caudalis: High and low intensity afferent stimulation differentially modulate early and late responses
T. Nishimori (1990)
10.1136/bmj.1.3973.431
Nocifensor System of Nerves*
T. Lewis (1937)
10.1177/0333102489009S10185
Subcutaneous GR43175 in the Treatment of Acute Migraine: An International Study
M. Ferrari (1989)
10.1002/ANA.410240607
Ergot alkaloids block neurogenic extravasation in dura mater: Proposed action in vascular headaches
K. Saito (1988)
Direct evidence for neuro - genic inflammation and its prevention by denervation and by pretreat - m
N. Jancsó (1967)
10.1523/JNEUROSCI.07-12-04129.1987
Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain
S. Markowitz (1987)
10.1136/jnnp.46.7.611
Facial flushing after thermocoagulation of the Gasserian ganglion.
P. Drummond (1983)
10.1002/ANA.410230214
Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
P. J. Goadsby (1988)



This paper is referenced by
10.1016/S0140-6736(14)61814-6
Chronic whiplash-associated disorders
Andreas R. Otte (2014)
10.1016/S0072-9752(10)97021-8
Migraine general aspects.
M. Moskowitz (2010)
10.1046/j.1468-2982.23.s1.1.x
Peripheral and Central Activation of Trigeminal Pain Pathways in Migraine: Data From Experimental Animal Models
M. G. Buzzi (2003)
10.1111/J.1442-2026.1995.TB00234.X
The emergency department management of migraine
Anne-Maree Kelly (2009)
10.1016/j.neuroscience.2011.12.019
Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat
D. R. Loyd (2012)
PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder
David Vállez García (2015)
Hypothesis Testing of the “ Neurogenic Inflammation Theory of Migraine ” : Selective Inhibition of Dural PPE
S. Peroutka (2005)
10.1111/j.1526-4610.2008.01127.x
Favorable Response to Analgesics Does Not Predict a Benign Etiology of Headache
J. V. Pope (2008)
10.1016/j.semcdb.2012.09.002
Serotonergic neuromodulation of peripheral nociceptors.
D. R. Loyd (2013)
10.1007/BF00188214
Innervation of the dura mater encephali of cat and rat: ultrastructure and calcitonin gene-related peptide-like and substance P-like immunoreactivity
K. Messlinger (2004)
10.1007/s00729-005-0109-y
Neurophysiologie psychosomatischer Schmerzen
J. C. Rüegg (2005)
10.1364/FIO.2013.JW3A.25
Near-Infrared Spectroscopy for Real-Time Brain Perfusion Diagnostics in Patients with Late Whiplash Syndrome
Andreas Otte (2013)
10.1124/MI.5.5.10
Neurogenic inflammation and migraine: implications for the therapeutics.
S. Peroutka (2005)
10.1016/j.lfs.2019.116901
Inhibition of ovalbumin-induced allergic rhinitis by sumatriptan through the nitric oxide pathway in mice.
Sara Hemmati (2019)
10.1146/annurev-physiol-030212-183717
Pathophysiology of migraine.
D. Pietrobon (2013)
10.1007/978-3-642-18773-5_16
The Late Whiplash Syndrome: Current Aspects of Functional Neuroimaging
A. Otte (2004)
10.1016/j.ebiom.2016.07.008
Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders
David Vállez García (2016)
10.1007/978-3-030-16215-3
Functional Neuroimaging in Whiplash Injury
Prof. Dr. A. Otte (2019)
Calcitonin Gene-Related Peptide and Migraine: Implications for Therapy
U. Arulmani (2004)
10.1111/fcp.12317
Pharmacological evidence of involvement of nitric oxide pathway in anti‐pruritic effects of sumatriptan in chloroquine‐induced scratching in mice
Nazgol-Sadat Haddadi (2018)
10.5772/65737
Primary Headaches and their Relationship with the Autonomic Nervous System
Cuciureanu Dan Iulian (2017)
10.1097/scs.0b013e31802c05ab
Posterior Cranial Fossa Box Expansion Leads to Resolution of Symptomatic Cerebellar Ptosis Following Chiari I Malformation Repair
J. Heller (2007)
10.1016/j.coph.2008.12.007
CGRP receptors in the control of pain and inflammation.
S. Benemei (2009)
10.1016/j.ejpain.2011.08.002
Functional neuroimaging in whiplash injury
A. Otte (2012)
10.1007/BF02333240
Causes and mechanisms of primary headaches: toward a bio-behavioral model
M. Buzzi (2006)
10.1007/s10194-005-0165-2
The pathophysiology of migraine: year 2005
M. G. Buzzi (2005)
10.1046/j.1526-4610.2003.03024.x
Migraine Aggravation Caused by Cephalic Venous Congestion
F. Doepp (2003)
10.1007/978-3-7985-1838-4_23
Langzeitfolgen des HWS-Schleudertraumas
A. Otte (2009)
10.1055/s-0030-1249222
Pathophysiology of migraine.
F. M. Cutrer (2010)
10.1967/s002449911000
Pathophysiological interrelated deactivation/activation processes in the exhausted brain after whiplash injury.
A. Otte (2019)
10.1523/JNEUROSCI.0232-19.2019
CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP's Role in Migraine with Aura
Aaron J. Schain (2019)
The Role of Hormonal and Vascular Genes in Migraine
N. Colson (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar