Online citations, reference lists, and bibliographies.
← Back to Search

Feedback Control Of Milk Secretion From Milk

M. Peaker, C. Wilde
Published 2005 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Extracellular storage allows biologically-active substances in milk to influence mammary function. Among these factors is one which regulates the rate of milk secretion acutely according to frequency or completeness of milk removal in each mammary gland. The active factor in goat's milk has been identified by screening milk constituents for their ability to inhibit milk constituent secretion in tissue and cell culture bioassays, and found to be a novel milk protein. The proteins identified by bioassayin vitro, also inhibited milk secretion in lactating goats in a reversible, concentration-dependent manner. This protein, termed FIL (feedback inhibitor of lactation), acts by reversible blockade of constitutive secretion in the mammary epithelial cell. As the inhibitor is synthesized in the same epithelial cells, feedback inhibition is, therefore, an autocrine mechanism. FIL's unusual mechanism of action also influences other aspects of mammary function. Acute disruption of mammary membrane trafficking is associated with downregulation of prolactin receptors and followed by a decrease in epithelial cell differentiation. Thus, in addition to acutely-regulating milk secretion, FIL may induce the adaptation in mammary cell differentiation which actsin vivo to sustain the secretory response to a sustained change in milk removal. In the long term, matching of milk output to demand is achieved by a change in mammary cell number. This developmental response is also local in nature. Whether it too is due to autocrine modulation by FIL of mechanisms influencing cell proliferation or survival, or elicited by another milk-borne factor, remains to be determined.
This paper references
10.1007/978-1-4615-1973-7_46
A Role for Medium-Chain Fatty Acids in the Regulation of Lipid Synthesis in Milk Stasis?
D. Williamson (1995)
Produc - tion of mammastatin , a tissue - specific growth inhibitor by normal human mammary epithelial cells
M. Wicha (1989)
10.1007/BF00417859
Apoptosis in lactating and involuting mouse mammary tissue demonstrated by nick-end DNA labelling
L. Quarrie (2004)
Milk lipid globule precursor release from endoplasmic reticulum reconstituted in a cell-free system.
T. Keenan (1992)
10.1016/0962-8924(92)90023-g
Okadaic acid induces Golgi apparatus fragmentation and arrest of intracellular transport.
J. Lucocq (1991)
10.1042/BST0150916
Effect of a fraction of goat milk serum proteins on milk accumulation and enzyme activities in rabbit mammary gland
C. Wilde (1987)
10.1210/ENDO.131.1.1377124
Expression of a lactogen-dependent insulin-like growth factor-binding protein in cultured mouse mammary epithelial cells.
P. Fielder (1992)
10.1016/S0074-7696(08)62312-8
Cell death: the significance of apoptosis.
A. Wyllie (1980)
Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.
C. Sell (1995)
10.1210/EDRV-14-6-710
Hormones and growth factors in milk.
C. E. Grosvenor (1993)
10.1007/BF02631326
Extracellular matrix and mouse mammary cell function: Comparison of substrata in culture
W. Hurley (2007)
10.1126/SCIENCE.1957170
Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein.
J. Donaldson (1991)
The effect of goat ' s milk fractions on synthesis of milk constituents by rabbit mammary explants and on milk yield in vivo
M. Peaker (1987)
Regulation of mammary prolactin binding by secreted milk proteins
M. Peaker (1991)
Inhibition of constitutive protein secretion from lactating mouse mammary epithelial cells by FIL (feedback inhibitor of lactation), a secreted milk protein.
M. Rennison (1993)
10.1677/JOE.0.1310001
Hormones in milk: chemical signals to the offspring?
M. Peaker (1991)
10.1016/S0091-679X(08)61935-4
Programmed cell death during mammary gland involution.
R. Strange (1995)
10.1007/978-1-4615-1973-7_25
Production of an Insulin-Like Growth Factor Binding Protein by the Involuting Rat Mammary Gland
E. Tonner (1995)
10.1002/AJA.1001850104
Cell death by apoptosis during involution of the lactating breast in mice and rats.
N. Walker (1989)
10.1002/(SICI)1097-4652(199609)168:3<559::AID-JCP8>3.0.CO;2-O
Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasis
L. Quarrie (1996)
10.1016/0305-0491(93)90178-8
Isolation of a goat acetyl-CoA carboxylase complementary DNA and effect of milking frequency on the expression of the acetyl-CoA carboxylase and fatty acid synthase genes in goat mammary gland.
M. Travers (1993)
10.1042/BST022178S
Local regulation of mammary apoptosis in the lactating goat.
L. Quarrie (1994)
Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane.
M. Barcellos-Hoff (1989)
10.1113/jphysiol.1996.sp021230
Effects of immunization against an autocrine inhibitor of milk secretion in lactating goats.
C. Wilde (1996)
10.1093/NAR/20.19.5243
A simple and rapid method for detection of apoptosis in human cells.
F. Roesl (1992)
10.1021/BI00350A005
Basement membrane complexes with biological activity.
H. Kleinman (1986)
10.1007/BF01322594
Autocrine regulation of mammary cell differentiation
C. Wilde (2005)
10.1038/364818A0
Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex
M. A. Matteis (1993)
10.1007/978-1-4615-3500-3_5
Mammary-derived growth inhibitor (MDGI).
R. Grosse (1992)
Apoptotic cell death and tissue remodelling during mouse mammary gland involution.
R. Strange (1992)
10.1210/ENDO.137.5.8612482
The role of prolactin and growth hormone in the regulation of casein gene expression and mammary cell survival: relationships to milk synthesis and secretion.
M. Travers (1996)
10.1016/0092-8674(89)90685-5
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
J. Lippincott-Schwartz (1989)
10.1007/978-1-4684-5949-4_17
Presence of insulin-like growth factors and their binding proteins in rat milk.
A. Philipps (1991)
10.1007/978-1-4615-1973-7_43
Autocrine Control of Milk Secretion: Development of the Concept
M. Peaker (1995)
Regulation of mammary prolactin binding by secreted milk proteins
M. Peaker (1991)
10.1042/BST021294S
Effect of unilateral changes in milking frequency on mammary mRNA concentrations in the lactating goat.
J. M. Bryson (1993)
10.1083/JCB.117.2.269
Proteins are secreted by both constitutive and regulated secretory pathways in lactating mouse mammary epithelial cells
M. D. Turner (1992)
Investigation of the role of microtubules in protein secretion from lactating mouse mammary epithelial cells.
M. Rennison (1992)
10.2527/JAS1987.642533X
Effects of long-term thrice-daily milking on mammary enzyme activity, cell population and milk yield in the goat.
C. Wilde (1987)
10.1210/ENDO-129-2-671
The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins.
M. Mcgrath (1991)
10.1126/SCIENCE.2662405
Production of mammastatin, a tissue-specific growth inhibitor, by normal human mammary cells.
J. Ervin (1989)
10.1042/BJ3050051
Autocrine regulation of milk secretion by a protein in milk.
C. Wilde (1995)
10.1126/science.7531366
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
N. Boudreau (1995)
10.1113/jphysiol.1979.sp012921
Adaptive hyperplasia and compensatory growth in the salt glands of ducks and geese.
C. Knight (1979)
10.1016/0143-4160(92)90018-N
Mechanically induced electrical and intracellular calcium responses in normal and cancerous mammary cells.
K. Enomoto (1992)
10.1016/0014-5793(91)81438-E
Trimeric G‐proteins of the trans‐Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules
F. Barr (1991)
10.1007/BF01323401
Morphogenesis and secretory activity of mouse mammary cultures on EHS biomatrix
M. Neville (2005)
10.1042/BJ2020133
Extensive destruction of newly synthesized casein in mammary explants in organ culture.
H. Razooki Hasan (1982)
10.1042/BJ1291171
Measurements of substrate uptake by mammary gland of the rat.
R. Hawkins (1972)
10.1016/0739-7240(92)90012-M
Mammary-derived growth inhibitor in lactation and involution.
I. Politis (1992)
10.1016/0020-711X(93)90661-W
Association of cytosolic lipids with fatty acid synthase from lactating mammary gland.
B. H. Keon (1993)
10.1007/BF01403376
Identification of human milk α-lactalbumin as a cell growth inhibitor
M. Thompson (2005)
10.1042/BJ2860013
Exocytosis from permeabilized lactating mouse mammary epithelial cells. Stimulation by Ca2+ and phorbol ester, but inhibition of regulated exocytosis by guanosine 5'-[gamma-thio]triphosphate.
M. D. Turner (1992)
10.1042/BJ2810273
Chain-length dependency of interactions of medium-chain fatty acids with glucose metabolism in acini isolated from lactating rat mammary glands. A putative feed-back to control milk lipid synthesis from glucose.
K. Heesom (1992)
10.1113/expphysiol.1991.sp003505
Regulation of mouse mammary cell differentiation by extracellular milk proteins
C. Wilde (1991)
Preparation and culture of mammary gland explants.
R. Dils (1981)
The role of insulin like growth factors binding proteins ( IGFBPs ) in regulating active cell death in regressing rat prostate and mammary gland
D. J. Flint (1995)
10.1016/0305-0491(86)90205-1
Degradation of newly-synthesised casein in mammary explants from pregnant and lactating goats.
C. Wilde (1986)
10.1007/BF00319044
Annexin II (calpactin I) in the mouse mammary gland: immunolocalisation by light- and electron microscopy
S. E. Handel (2004)
10.1113/jphysiol.1971.sp009549
The effects of oxytocin and milk removal on milk secretion in the goat
J. L. Linzell (1971)
10.1042/BJ2420285
The effect of goat milk fractions on synthesis of milk constituents by rabbit mammary explants and on milk yield in vivo. Evidence for autocrine control of milk secretion.
C. Wilde (1987)
10.1083/JCB.112.1.39
Reconstitution of constitutive secretion using semi-intact cells: regulation by GTP but not calcium
S. Miller (1991)
10.1007/978-1-4615-1973-7_21
Local Control of Mammary Apoptosis by Milk Stasis
L. Quarrie (1995)
10.1007/978-1-4615-1973-7_48
In Vitro Effects of Oxytocin and Ionomycin on Lipid Secretion by Rat Mammary Gland. Role of the Myoepithelial Cells
T. Costa (1995)
Expression of a lactogendependent insulin - like growth factorbinding protein in cultured mouse mammary epithelial cells
R. G. Rosenfield (1992)
10.1007/BF00374271
The increase in the intracellular Ca2+ concentration induced by mechanical stimulation is propagated via release of pyrophosphorylated nucleotides in mammary epithelial cells
Koh -ichi Enomoto (2004)
10.1016/S0076-6879(81)72063-9
[61] Preparation and culture of mammary gland explants
R. Dils (1981)
10.1007/BF00220616
Early effects of prolactin on lactating rabbit mammary gland
M. Ollivier-Bousquet (2004)
10.1016/0092-8674(91)90273-2
Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae
Lelio Orcl (1991)
10.1083/JCB.116.6.1343
Evidence for the regulation of exocytic transport by protein phosphorylation
H. Davidson (1992)
Vectorial secretion by constitutive and regulated secretory pathways in mammary epithelial cells.
D. Blatchford (1995)
Reconstitution of steps in the constitutive secretory pathway in permeabilized cells. Secretion of glycosylated tripeptide and truncated sphingomyelin.
J. B. Helms (1990)
Insulin - like growth factor I ( IGFI ) and the IGF - 1 receptor prevent etoposideinduced apoptosis
M. Peaker (1995)
10.1007/BF00374284
Spontaneous calcium oscillations and mechanically and chemically induced calcium responses in mammary epithelial cells
K. Furuya (2004)



This paper is referenced by
10.1016/J.BBAGEN.2006.07.014
The expression of β-1,3 galactosyltransferase and β-1,4 galactosyltransferase enzymatic activities in the mammary gland of the tammar wallaby (Macropus eugenii) during early lactation
K. Menzies (2007)
Effects of omitting one udder quarter at one single milking
R. Nilsson (2016)
10.3168/JDS.S0022-0302(03)73828-4
Effect of omitting one milking weekly on lactational performances and morphological udder changes in dairy cows.
M. Ayadi (2003)
10.1017/S0022029904000585
Effects on milk yield of milking interval regularity and teat cup attachment failures with robotic milking systems.
A. Bach (2005)
10.2527/2004.822563X
Coping capacity of dairy cows during the change from conventional to automatic milking.
D. Weiss (2004)
10.1016/J.SMALLRUMRES.2019.07.001
Mammary involution and relevant udder health management in sheep
I. G. Petridis (2019)
10.1016/j.nut.2020.110969
Physiologic changes in serotonin concentrations in breast milk during lactation.
T. Maeda (2020)
10.1007/978-3-319-14892-2_11
Biologically Active Compounds in Milk
P. Fox (2015)
Understanding the hormonal regulation of mouse lactogenesis by transcriptomics and literature analysis
Maurice H. T. Ling (2009)
10.1023/A:1026321529451
Interactions of Prolactin and Growth Hormone (GH) in the Regulation of Mammary Gland Function and Epithelial Cell Survival
D. Flint (2004)
Keeping Goats and Kids Together – Focus on Milk Ejection , Milk Composition , Curd Yield and Animal Welfare
M. Högberg (2016)
Primary Cilia in the Bovine Mammary Gland: Characterising Ciliary Distribution and Morphology During Lactation and Involution
Melanie J. Millier (2013)
10.3168/jds.2015-9828
Autocrine-paracrine regulation of the mammary gland.
S. Weaver (2016)
Effects of take-off level at udder quarter level and feeding during milking on milk fat quality and milk somatic cell count in an automatic milking system
Maria Tegevall (2017)
10.3168/JDS.S0022-0302(03)73787-4
Modeling the interaction of milking frequency and nutrition on mammary gland growth and lactation.
I. Vetharaniam (2003)
10.1007/978-94-007-6812-3_17
Breastfeeding the Preterm Infant
P. Sharon (2013)
10.1177/1099800409331394
Association of Serum Prolactin and Oxytocin With Milk Production in Mothers of Preterm and Term Infants
P. Hill (2009)
10.1001/jama.2009.877
Association of nipple piercing with abnormal milk production and breastfeeding.
C. P. Garbin (2009)
10.1017/S0022029905001329
Oxytocin release and lactation performance in Syrian Shami cattle milked with and without suckling.
S. Kaskous (2006)
Milk yield has an impact on success of milking events in automatic milking systems
F. M. Masía (2018)
Improvements in milking management through imitation of calf behaviour
Ida Eriksson (2013)
10.1152/physiolgenomics.00108.2009
Effects of reduced frequency of milk removal on gene expression in the bovine mammary gland.
M. Littlejohn (2010)
10.1097/AOG.0000000000000142
Enabling Women to Achieve Their Breastfeeding Goals
A. Stuebe (2014)
10.1016/B978-0-12-397175-3.00046-6
Lactation and Its Hormonal Control
S. Anderson (2015)
expression in the bovine mammary gland Effects of reduced frequency of milk removal on gene
R. Spelman (2015)
10.1517/14740338.4.4.745
Drug use and breastfeeding
K. Ilett (2005)
10.1023/A:1018717006152
Control of Milk Secretion and Apoptosis DuringMammary Involution
C. Wilde (2004)
Interaction between dairy cow physiology and milking technology
D. Weiss (2004)
10.1097/JNR.0b013e31821988e9
Factors Related to Milk Supply Perception in Women Who Underwent Cesarean Section
Su-ying Lin (2011)
The development of sucking, swallowing and breathing patterns in healthy term breastfeeding infants
Vanessa Susanna Sakalidis (2013)
Modifying the Lactation Curve in Dairy Goats: Effects of Milking Frequency, Dry Period, and Kidding Interval
A. Salama (2005)
10.3390/nu10050600
Supporting Mothers of Very Preterm Infants and Breast Milk Production: A Review of the Role of Galactogogues
E. Asztalos (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar