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The Thickness Of The Mucus Layer In Different Segments Of The Rat Intestine

L. Szentkuti, K. Lorenz
Published 2004 · Biology

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SummaryThe thickness of the pre-epithelial mucus layer has been measured in different gut segments of rats kept under normal (ad libitum) feeding conditions, and after 48 h of fasting, using cryostat sections and celloidin stabilization from samples containing luminal contents. The mucus layer of the stomach, duodenum, jejunum, ileum, caecum, proximal colon, colon transversum, distal colon and rectum was studied in five groups of male rats (10, 40, 70 and 150 days of age, and older). Underad libitum feeding conditions, a distinct and continuous mucus layer, with a thickness of more than 3 μm, was only observed in the colon transversum, in the distal colon, in the rectum and in the stomach. No pre-epithelial mucus layer was observed in the duodenum and jejunum where the glycocalix from the apical membrane of the superficial cells appeared to be in a direct contact with the luminal ingesta. In the ileum, caecum and the proximal colon, the surface epithelium of the mucosa was only partly covered by a mucus layer of highly variable thickness. After 48 h of fasting, a mucus layer of 28.8 ± 25.6 μm and 93.3 ± 59.4 μm thickness, respectively, was found in the duodenum and jejunum of adult rats, but no increase in the thickness of the mucus layer was observed in the rat hind gut.
This paper references
Stabilization of pre-epithelial mucus gel in cryostat sections from rat colon with celloidin.
L. Szentkuti (1990)
A simple method for measuring thickness of the mucus gel layer adherent to rat , frog and human gastric mucosa : influence of feeding , prostaglandin , Nacetylcysteine and other agents
S. KERSS (1982)
Immune exclusion and mucus trapping during the rapid expulsion of Nippostrongylus brasiliensis from primed rats.
H. Miller (1981)
Movement of Entamoeba histolytica trophozoites in rat cecum and colon intact mucus blankets and harvested mucus gels.
G. Leitch (1988)
Gastro - intestinal mucus : synthesis , secretion , and function
L. R. JOHNSON (1987)
Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion
A. Rubinstein (2004)
A simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: influence of feeding, prostaglandin, N-acetylcysteine and other agents.
S. Kerss (1982)
Luminal mucin in the large intestine of mice, rats and guinea pigs
T. Sakata (2004)
Pre-epithelial mucus layer in the colon of conventional and germ-free rats
L. Szentkuti (2005)
Histochemistry: Theoretical and Applied
A. G. Pearse (1953)
An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop
C. Lehr (1991)
Protection against nematodes by intestinal mucus.
H. Miller (1982)
L u m i n a l m u c i n in the large intestine of mice , rats and guinea pigs
B. SANDZ N (1981)
Gastric mucus gel layer thickness measured by direct light microscopy. An experimental study in the rat.
B. Sandzén (1988)
Gastric and duodenal surface mucus gel thickness in rat: effects of prostaglandins and damaging agents.
S. McQueen (1983)
Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa.
C. Schade (1994)
The intestinal mucus barrier to parasites and bacteria.
G. B. Lee (1982)
Pro tec t ion aga ins t nematodes by intestinal mucus
H. R. P. MILLER (1982)
Preservation of mucusIn situ in rat colon
Jane E. Bollard (1986)
Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis.
R. D. Pullan (1994)
Mucus: The Front Line of Intestinal Mucosal Defense
J. Lamont (1992)

This paper is referenced by
Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement.
N. G. Schipper (1999)
Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract.
Y. Masaoka (2006)
Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract
M. Furter (2019)
Progress and future of in vitro models to study translocation of nanoparticles
H. Braakhuis (2015)
The influence of small intestinal mucus structure on particle transport ex vivo.
Balázs H. Bajka (2015)
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
S. Lai (2009)
The VSL# 3 probiotic mixture modifies microflora but does not heal chronic dextran-sodium sulfate-induced colitis or reinforce the mucus barrier in mice.
E. Gaudier (2005)
Nanomedicine for treatment of diabetes in an aging population: state-of-the-art and future developments.
S. Krol (2012)
Strategies for improving mucosal drug delivery.
Flavia Laffleur (2013)
Developmental changes in distribution of the mucous gel layer and intestinal permeability in rat small intestine.
Y. Iiboshi (1996)
Critical determinant of intestinal permeability and oral bioavailability of pegylated all trans-retinoic acid prodrug-based nanomicelles: Chain length of poly (ethylene glycol) corona.
Zhenbao Li (2015)
Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.
M. Vertzoni (2019)
Chapter 16 – Gastrointestinal System
M. Jepson (2017)
Chapter 4 – Mucus
R. Cone (2005)
Formulation optimization and in situ absorption in rat intestinal tract of quercetin-loaded microemulsion.
Y. Gao (2009)
Hydrodynamics of defecation.
P. Yang (2017)
Differences between intestinal segments and soybean meal-induced changes in intestinal mucus composition of common carp Cyprinus carpio L.
M. V. D. Marel (2014)
Analyses of drag on viscoelastic liquid infused bio-inspired patterned surfaces
Manjunath C Rajagopal (2016)
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