Online citations, reference lists, and bibliographies.

In Vitro Dissolution Of Calcium Carbonate Preparations

M. Brennan, W. E. Duncan, L. Wartofsky, V. M. Butler, H. Wray
Published 2007 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
SummaryCalcium supplements are widely used for the treatment of osteoporosis. The bioavailability of these preparations is unknown. Because poor tablet dissolution accounts for a majority of drug bioavailability problems, we determined thein vitro dissolution at 30, 60, and 90 minutes of 27 commercially available calcium carbonate supplements using the method of the U.S. Pharmacopoiea. At 30 minutes, five preparations (18%) were more than 75% dissolved, four (15%) between 33 and 74%, and the remaining 18 (67%) were less than 33% dissolved. After 90 minutes, 17 (63%) of the preparations were less than 50% dissolved. Dissolution correlated negatively with the weight of filler (noncalcium carbonate material in the tablet) (rs=−0.51,P<0.01) but not with tablet hardness or cost. Simila to previous studies, we also found no correlation of dissolution with the stated calcium content, chemical source of calcium carbonate (oyster shell or chemical precipitate), or retail source. We conclude that there is a wide range ofin vitro dissolution among the calcium carbonate preparations tested, and that the filler is an important determinant of the dissolution of these tablets. These results raise concern about the bioavailability of the calcium in these preparations and may have important implications for the therapeutic use of the various calcium carbonate supplements.
This paper references
Fifth supplement USPNF : official monographs USP XXI
RP Heaney
10.1210/jcem-65-4-801
Enhanced calcium bioavailability from a solubilized form of calcium citrate.
C. Pak (1987)
Consensus Development Conference on Osteoporosis. Hong Kong, April 1-2, 1993.
(1993)
Hypocalciuria in achlorhydria
P Charles (1986)
10.1210/jcem-61-2-391
Calcium bioavailability from calcium carbonate and calcium citrate.
M. Nicar (1985)
cium absorbability from milk products , an imitation milk , and calcium gluconate
FR Steggerda (1988)
10.1056/NEJM199009273231319
Calcium bioavailability from two calcium carbonate preparations.
H. Koh (1990)
10.1093/jn/55.3.519
Further experiments on the utilization of calcium from salts by college women.
M. B. Patton (1955)
FDA's report on drug dissolution
BE Cabana (1980)
10.1056/NEJM198701223160401
Does calcium supplementation prevent postmenopausal bone loss? A double-blind, controlled clinical study.
B. Riis (1987)
10.1056/NEJM198507113130202
Calcium absorption and achlorhydria.
R. Recker (1985)
10.7326/0003-4819-66-5-917
The absorption of calcium carbonate.
P. Ivanovich (1967)
10.1056/NEJM198708273170903
Gastrointestinal absorption of calcium from milk and calcium salts.
M. Sheikh (1987)
10.7326/0003-4819-87-6-649
Effect of estrogens and calcium carbonate on bone loss in postmenopausal women.
R. Recker (1977)
Calcium bioavailability from oral calcium carbonate, calcium phosphate and bone meal (G. P. calcium)
P Charles (1986)
10.1093/ajcn/47.5.884
Intestinal absorption of Ca(H2PO4)2 and Ca citrate compared by two methods.
S. Schuette (1988)
Calcium carbonate tablets--be sure to specify
JG Valentino (1988)
10.1093/ajcn/44.5.653
Short-term effects of calcium carbonate, lactate, and gluconate on the calcium-parathyroid axis in normal elderly men and women.
M. Goddard (1986)
10.1093/jn/48.4.443
The utilization of calcium from lactate, gluconate, sulfate and carbonate salts by young college women.
M. B. Patton (1952)
10.1093/ajcn/47.1.93
Calcium absorbability from milk products, an imitation milk, and calcium carbonate.
R. Recker (1988)
10.1007/BF02555721
Influence of accompanying anion on intestinal radiocalcium absorption
X. Marchandise (2007)
10.1016/0020-7292(91)90314-U
A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women.
B. Dawson-Hughes (1990)
10.1093/ajcn/48.5.1291
Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents.
J. Miller (1988)
10.1172/JCI111254
An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
G. Bo-Linn (1984)
10.1016/S0272-6386(89)80145-3
Variable Efficacy of Calcium Carbonate Tablets
S. Kobrin (1989)
10.1136/bmj.289.6452.1103
Calcium supplementation and postmenopausal bone loss.
L. Nilas (1984)
Factors to consider in the selection of a calcium supplement.
Shangraw Rf (1989)
10.1093/jn/89.3.283
Comparative absorption of calcium from calcium gluconate and calcium lactate in man.
H. Spencer (1966)
10.1093/jn/31.4.423
The effect of the citrate ion on the calcium metabolism of adult human subjects.
F. R. Steggerda (1946)
10.1007/BF02563819
Absorbability of calcium sources: The limited role of solubility
R. Heaney (2007)
10.1002/JBMR.5650030303
Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate.
J. Harvey (1988)
10.1136/bmj.2.6090.789
Prospective trial of oestrogen and calcium in postmenopausal women.
A. Horsman (1977)



This paper is referenced by
Casein-maltodextrin Conjugates as Emulsifiers for Preparation of Structured Calcium Carbonate Particles as Fat Globule Mimetics
Bai Qu (2014)
Casein-maltodextrin Conjugates as Emulsifiers for Preparation of Structured Calcium Carbonate Particles as Fat Globule Mimetics
Q. Zhong (2014)
10.1016/J.TIFS.2019.07.021
Eggshell calcium: a cheap alternative to expensive supplements
Marium Waheed (2019)
Casein-maltodextrin Conjugates as Emulsifiers for Preparation of Structured Calcium Carbonate Particles as Fat Globule Mimetics
Bai Qu (2018)
10.3109/00365520903434117
Hypochlorhydric stomach: a risk condition for calcium malabsorption and osteoporosis?
P. Sipponen (2010)
10.1007/s11051-016-3608-6
Dissolution and storage stability of nanostructured calcium carbonates and phosphates for nutrition
Lidija Posavec (2016)
10.1016/j.talanta.2005.04.068
Dynamic continuous-flow dialysis method to simulate intestinal digestion for in vitro estimation of mineral bioavailability of food.
J. Shiowatana (2006)
10.3760/CMA.J.ISSN.1007-9742.2008.02.140
Calcium supplementation
M. LappeJoan (2008)
10.3945/jn.108.101071
Diet calcium level but not calcium supplement particle size affects bone density and mechanical properties in ovariectomized rats.
Mohammad Shahnazari (2009)
10.3945/jn.116.241927
Chemical Composition, but Not Specific Surface Area, Affects Calcium Retention of Nanostructured Calcium Compounds in Growing Rats.
Lidija Posavec (2017)
10.3390/molecules25030659
Impact Mineralization of Chokeberry and Cranberry Fruit Juices Using a New Functional Additive on the Protection of Bioactive Compounds and Antioxidative Properties
Sabina Lachowicz (2020)
10.1093/AJCN/85.1.269S
Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions.
E. Yetley (2007)
10.1016/B978-012183502-6/50023-7
Management of Bone Disease in Candidates for Organ Transplant
S. Ott (2005)
10.1093/AJCN/85.5.1428
Effects of dietary calcium compared with calcium supplements on estrogen metabolism and bone mineral density.
N. Napoli (2007)
ESTUDO DE DISSOLUÇÃO IN VITRO DE COMPRIMIDOS DE CARBONATO DE CÁLCIO
A. M. Reis (2013)
Calcium Acetate Versus Calcium Carbonate as Oral Phosphate Binder: Preparation and In Vitro Assessment
N. Tavakoli (2005)
10.1080/10942912.2015.1004587
In Vitro Dissolution of Calcium Carbonate from the Chicken Eggshell: A Study of Calcium Bioavailability
Łukasz Szeleszczuk (2015)
10.1111/j.1440-1797.2012.01604.x
Effect of gastric acid suppression with pantoprazole on the efficacy of calcium carbonate as a phosphate binder in haemodialysis patients.
Matthew J Cervelli (2012)
Semantic Scholar Logo Some data provided by SemanticScholar