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Omeprazole, A Specific Inhibitor Of H+−K+-ATPase, Inhibits Bone Resorptionin Vitro

J. Tuukkanen, H. Väänänen
Published 2007 · Biology, Medicine
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SummaryOmeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+−K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.



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