Referencing for people who value simplicity, privacy, and speed.Get Citationsy
← Back to Search
Supercritical CO2 Processing Of Polymers For The Production Of Materials With Applications In Tissue Engineering And Drug Delivery
A. López-Periago, A. Vega, P. Subra, A. Argemí, J. Saurina, C. García-González, C. Domingo
Published 2008 · Materials Science
Save to my Library
Download PDFAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Supercritical carbon dioxide (SCCO2) was used for the preparation of foamed sponges and intermingled fibers of biopolymers with potential applications in tissue engineering and drug delivery. The work was focused on the processing of both biodegradable polylactic acid (l-PLA) and non-biodegradable polymethylmethacrylate (PMMA) homopolymers. Monolithic porous sponges of amorphous PMMA were prepared using SCCO2 as a porogen agent by simple swelling and foaming. Under similar experimental conditions, l-PLA was crystallized. The study also addresses the impregnation of biopolymers with an active agent dispersed in SCCO2. The drug used for impregnation was triflusal, a platelet antiaggregant inhibitor for thrombogenic cardiovascular diseases. Foaming often leads to a closed pore structure after depressurization which is disadvantageous for 3D scaffolds as it does not fulfill the requirement of interconnectivity necessary for cell migration. To overcome these drawbacks, fibers forming macroporous structures were prepared using a semicontinuous antisolvent (SAS) technique.
This paper references
Investigation of the structure of solution grown crystals of lactide copolymers by means of chemical reactions
E. Fischer (1973)
A novel method to fabricate bioabsorbable scaffolds
K. Whang (1995)
Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents.
D. Mooney (1996)
Nano-fibrous poly(L-lactic acid) scaffolds with interconnected spherical macropores.
Victor J. Chen (2004)
Materials processing in supercritical carbon dioxide: surfactants, polymers and biomaterials
H. Woods (2004)
Recent development of polymer nanofibers for biomedical and biotechnological applications
Y. Zhang (2005)
Materials for protein delivery in tissue engineering.
Mark Saltzman W (1998)
Microcellular Foaming of Amorphous High-Tg Polymers Using Carbon Dioxyde
B. Krause (2001)
Effects of CO2 on crystallization kinetics of polypropylene
M. Takada (2001)
Formation of microporous polymer fibers and oriented fibrils by precipitation with a compressed fluid antisolvent
D. Dixon (1993)
Supercritical and near-critical CO2 in green chemical synthesis and processing
E. Beckman (2004)
Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering
K. Tuzlakoglu (2005)
Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation.
James A. Cooper (2005)
Supercritical fluid technologies and tissue engineering scaffolds
R. Quirk (2004)
Swelling and sorption in polymer-CO2 mixtures at elevated pressures
R. G. Wissinger (1987)
Polymeric Microspheres Prepared by Spraying into Compressed Carbon Dioxide
R. Bodmeier (2004)
Spectroscopy of polymer/drug formulations processed with supercritical fluids: in situ ATR-IR and Raman study of impregnation of ibuprofen into PVP.
S. G. Kazarian (2002)
3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties.
L. Moroni (2006)
Complex interactions among additive/supercritical CO2/polymer ternary systems and factors governing the impregnation efficiency
Qun Xu (2004)
Biomaterial developments for bone tissue engineering.
K. Burg (2000)
Supercritical impregnation of polymers
I. Kikic (2003)
Enhancement of dissolution rate of poorly soluble active ingredients by supercritical fluid processes. Part II: Preparation of composite particles.
M. Perrut (2005)
Retrograde vitrification of polymers with compressed fluid diluents: experimental confirmation
P. Condo (1992)
Supercritical fluid mixing: preparation of thermally sensitive polymer composites containing bioactive materials
S. Howdle (2001)
Production of different morphologies of biocompatible polymeric materials by supercritical CO(2) antisolvent techniques.
N. Elvassore (2001)
Polymeric Scaffolds for Bone Tissue Engineering
X. Liu (2004)
Porous methacrylate scaffolds: supercritical fluid fabrication and in vitro chondrocyte responses.
J. J. Barry (2004)
Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes. Part I: Micronization of neat particles.
M. Perrut (2005)
Polymer synthesis and processing using supercritical carbon dioxide
A. Cooper (2000)
Porous Materials and Supercritical Fluids
A. Cooper (2003)
Polymer microparticles production by supercritical assisted atomization
E. Reverchon (2007)
Biomimetic materials for tissue engineering.
H. Shin (2003)
Scaffolds in tissue engineering bone and cartilage.
D. Hutmacher (2000)
Controlled drug delivery : fundamentals and applications
J. Robinson (1987)
COMPOSITIONAL QUENCHING: A PROCESS FOR FORMING POLYMER-IN-POLYMER MICRODISPERSIONS AND COCONTINUOUS NETWORKS
E. Nauman (1988)
Porosity of 3D biomaterial scaffolds and osteogenesis.
V. Karageorgiou (2005)
Bioactive polymer surfaces via supercritical fluids
Taryn L Sproule (2004)
Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery.
M. Sheridan (2000)
Size controlled production of biodegradable microparticles with supercritical gases.
J. Thies (1998)
Mechanical characterization of collagen fibers and scaffolds for tissue engineering.
E. Gentleman (2003)
Polymer modification by supercritical impregnation
O. Muth (2000)
Generation of microcellular polymeric foams using supercritical carbon dioxide. II: Cell growth and skin formation
S. K. Goel (1994)
Supercritical carbon dioxide as a green solvent for processing polymer melts: Processing aspects and applications
S. Nalawade (2006)
A Review of CO2 Applications in the Processing of Polymers
D. Tomasko (2003)
Evaluation of drug delivery characteristics of microspheres of PMMA-PCL-cholesterol obtained by supercritical-CO2 impregnation and by dissolution-evaporation techniques.
C. Elvira (2004)
Polymer swelling and impregnation using supercritical CO2: A model-component study towards producing controlled-release drugs
Sinan Üzer (2006)
Sorption and swelling in glassy polymer/carbon dioxide systems: Part II—Swelling
Maria Pantoula (2006)
Controlled Drug Delivery : Fundamentals and Applications, Second Edition
J. Robinson (1987)
Sub‐Micrometer‐Sized Biodegradable Particles of Poly(L‐Lactic Acid) via the Gas Antisolvent Spray Precipitation Process
T. Randolph (1993)
Precipitation of PMMA/PCL blends using supercritical carbon dioxide
Arlette Vega-González (2004)
Specific Intermolecular Interaction of Carbon Dioxide with Polymers
S. G. Kazarian (1996)
This paper is referenced by
A supercritical removal method: the rapid elimination of impurities in polymethyl-methacrylate at near room temperature and a mechanism investigation of insulating property improvements
Kang Qi (2020)
Dense Gas Processing of Polymers
R. Yoganathan (2010)
Compressed antisolvent process for polymer coating of drug-loaded aerogel nanoparticles and study of the release behavior
Nerea Murillo-Cremaes (2014)
Generating phytosterol nanoparticles in nanoporous bioaerogels via supercritical carbon dioxide impregnation: Effect of impregnation conditions
Ali Ubeyitogullari (2017)
Preparation in supercritical CO2 of porous poly(methyl methacrylate)–poly(l-lactic acid) (PMMA–PLA) scaffolds incorporating ibuprofen
D. Velasco (2010)
ATR-FTIR spectroscopic imaging to study drug release and tablet dissolution
A. Ewing (2016)
Supercritical processing of CO2-philic polyhedral oligomeric silsesquioxane (POSS)-poly(l-lactic acid) composites
Novendra Novendra (2016)
Impregnation of a triphenylpyrylium cation into zeolite cavities using supercritical CO2
A. López-Periago (2009)
Methods for Particle Production: Antisolvent Techniques
C. D. Pascual (2015)
An overview of the analytical characterization of nanostructured drug delivery systems: towards green and sustainable pharmaceuticals: a review.
C. Domingo (2012)
How smart do biomaterials need to be? A translational science and clinical point of view.
B. Holzapfel (2013)
Supercritical fluids in biomedical and tissue engineering applications: a review
A. Duarte (2009)
General Description of Nonreactive Precipitation Methods
C. Domingo (2015)
Production of biodegradable porous scaffolds impregnated with indomethacin in supercritical CO2
L. Cabezas (2012)
Bio-based polymers, supercritical fluids and tissue engineering
A. Salerno (2015)
The effect of processing variables on morphological and mechanical properties of supercritical CO2 foamed scaffolds for tissue engineering.
L. White (2012)
Multiwalled carbon nanotubes grafted with polyamidoamine (PAMAM) dendrimers and their influence on polystyrene supercritical carbon dioxide foaming
Jintao Yang (2013)
Porogen Incorporation and Phase Inversion
L. Qian (2011)
Preparation of trityl cations in faujasite micropores through supercritical CO2 impregnation
A. López-Periago (2010)
Drug Loading of Sutures by Supercritical CO2 Impregnation: Effect of Polymer/Drug Interactions and Thermal Transitions
M. Champeau (2015)
Biological effect of gas plasma treatment on CO 2 gas foaming/salt leaching fabricated porous polycaprolactone scaffolds in bone tissue engineering
Tae-Yeong Bak (2014)
Development of a polymeric patch impregnated with naproxen as a model of transdermal sustained release system.
A. Argemí (2011)
Supercritical Fluid Nanotechnology: Advances and Applications in Composites and Hybrid Nanomaterials
C. D. Pascual (2015)
Measurement, correlation and modelling of high-pressure phase equilibrium of PLGA solutions in CO2
I. Álvarez (2020)
Effect of blowing agent composition and processing parameters on the low temperature foaming of poly(l-lactide/caprolactone) co-polymer by means of supercritical CO2/ethyl lactate binary mixtures
A. Salerno (2013)
Fabrication of poly-DL-lactide/polyethylene glycol scaffolds using the gas foaming technique.
C. Ji (2012)
Formation of Cyclodextrin-Drug Inclusion Compounds and Polymeric Drug Delivery Systems using Supercritical Carbon Dioxide
Heather E. Grandelli (2013)
Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester.
C. Gualandi (2010)
In‐situ extraction and impregnation of black walnut husk into polyethylene film using supercritical carbon dioxide with an ethanol modifier
J. Wenzel (2020)
ScCO2 Techniques for Surface Modification of Micro‐ and Nanoparticles
P. Subra-Paternault (2015)
Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs.
P. Veres (2015)
Nanostructured Materials Synthesis in Supercritical Fluids for Catalysis Applications
S. Marre (2012)See more