Online citations, reference lists, and bibliographies.
← Back to Search

Layered Double Hydroxide Modified By PEGylated Hyaluronic Acid As A Hybrid Nanocarrier For Targeted Drug Delivery

A. Dong, X. Li, W. Wang, Shangcong Han, Jianfeng Liu, Jinjian Liu, J. Zhao, Shuxin Xu, L. Deng
Published 2016 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and preferable disease treatments. In this study, using 5-fluorouracil(5-FU)as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system(LDH/HA-PEG/5-FU)was conceived and manufactured by the adsorption of PEGylated hyaluronic acid(HA-PEG)on the surface of layered double hydroxide(LDH, prepared via hydrothermal method)and the intercalation of 5-FU in the interlamination of LDH via ion exchange strategy. The drug loading amount of LDH/HA-PEG/5-FU achieved as high as 34.2%. LDH, LDH/5-FU and LDH/HA-PEG/5- FU were characterized by FT-IR, XRD, TGA, laser particle size analyzer and SEM. With the benefit of pHdegradable feature of LDH and enzyme-degradable feature of HA, LDH/HA-PEG/5-FU showed pH-degradable and enzyme-degradable capacity in in vitro drug release. Moreover, the drug carrier LDH/HA-PEG contained biocompatible PEG and tumor-targeted HA, resulting in lower cytotoxicity and better endocytosis compared with LDH in vitro. It was suggested that the organic-inorganic hybrid drug delivery system, which was endowed with the properties of controlled release, low toxicity and tumor-targeting delivery for ameliorative cancer therapy, was advisable and might be applied further to fulfill other treatments.
This paper references
Biologically erodable microspheres as potential oral drug delivery systems
E. Mathiowitz (1997)
A study on sustained release formulations for oral delivery of 5-fluorouracil based on alginate–chitosan/montmorillonite nanocomposite systems
Fahimeh Farshi Azhar (2014)
Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?
P. Ghosh (2002)
Facile synthesis of camptothecin intercalated layered double hydroxide nanohybrids via a coassembly route.
X. Wu (2013)
Contribution of hydrophobic/hydrophilic modification on cationic chains of poly(ε-caprolactone)-graft-poly(dimethylamino ethylmethacrylate) amphiphilic co-polymer in gene delivery.
Shangcong Han (2014)
Layered assembly of graphene oxide and Co-Al layered double hydroxide nanosheets as electrode materials for supercapacitors.
L. Wang (2011)
Synthesis of biocompatible, mesoporous Fe(3)O(4) nano/microspheres with large surface area for magnetic resonance imaging and therapeutic applications.
S. Xuan (2011)
Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles.
L. Li (2014)
Self-assembly and characterization of layered double hydroxide/DNA hybrids.
L. Désigaux (2006)
Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.
B. Samanta (2008)
Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles.
Y. Wong (2010)
Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.
R. C. Mundargi (2008)
Influence of microemulsions on cutaneous drug delivery.
M. Kreilgaard (2002)
Layered double hydroxide as an efficient drug reservoir for folate derivatives.
J. Choy (2004)
Thermosensitive in situ hydrogel of paclitaxel conjugated poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone)
X. Lin (2012)
Acid pH in tumors and its potential for therapeutic exploitation.
I. Tannock (1989)
Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles.
Katharina Ladewig (2010)
Preparation of layered double hydroxides and their applications as additives in polymers, as precursors to magnetic materials and in biology and medicine.
D. Evans (2006)
Release kinetics from LDH-drug hybrids: Effect of layers stacking and drug solubility and polarity
R. Rojas (2014)
Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery.
Y. Chen (2010)
Drug Delivery Systems: Entering the Mainstream
T. Allen (2004)
Graphene Nanosheet/Ni2+/Al3+ Layered Double-Hydroxide Composite as a Novel Electrode for a Supercapacitor
Zan Gao (2011)
Liposome-based delivery of a boron-containing cholesteryl ester for high-LET particle-induced damage of prostate cancer cells: A boron neutron capture therapy study
Ian Gifford (2014)
Impact of silica nanoparticle design on cellular toxicity and hemolytic activity.
T. Yu (2011)
Preparation of superhydrophobic and UV blocking cotton fabric via sol-gel method and self-assembly
Chengyu Pan (2012)
Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide.
A. I. Khan (2001)
Influence of nano-LDHs on char formation and fire-resistant properties of flame-retardant coating
Z. Wang (2005)
Multifunctional Au@mSiO2/rhodamine B isothiocyanate nanocomposites: cell imaging, photocontrolled drug release, and photothermal therapy for cancer cells.
Z. Jiang (2013)
Inorganic layered double hydroxides as a drug delivery system—intercalation and in vitro release of fenbufen
B. Li (2004)
Superparamagnetic graphene oxide–Fe3O4nanoparticles hybrid for controlled targeted drug carriers
X. Yang (2009)
Controlled Degradability of Polysaccharide Multilayer Films In Vitro and In Vivo
C. Picart (2005)
Designed Fabrication of a Multifunctional Polymer Nanomedical Platform for Simultaneous Cancer‐ Targeted Imaging and Magnetically Guided Drug Delivery
J. Kim (2008)
Selenium adsorption on Mg–Al and Zn–Al layered double hydroxides
Y. You (2001)
Stable suspension of layered double hydroxide nanoparticles in aqueous solution.
Z. P. Xu (2006)
Utilization of calcined Ni‐Al layered double hydroxide (LDH) as an Adsorbent for removal of methyl orange dye from aqueous solution
P. Monash (2014)
Biodegradable block copolymers as injectable drug-delivery systems
B. Jeong (1997)
Mg/Al Ordering in Layered Double Hydroxides Revealed by Multinuclear NMR Spectroscopy
P. Sideris (2008)
Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid.
Wendi Zhang (2013)
Layered Double Hydroxide Nano- and Microstructures Grown Directly on Metal Substrates and Their Calcined Products for Application as Li-Ion Battery Electrodes†
J. Liu (2008)
Quantum dots conjugated with Fe3O4-filled carbon nanotubes for cancer-targeted imaging and magnetically guided drug delivery.
M. Chen (2012)
cRGD grafted liposomes containing inorganic nano-precipitate complexed siRNA for intracellular delivery in cancer cells.
N. Khatri (2014)
pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy.
Yi-Ting Chiang (2014)
LDPE/Mg–Al layered double hydroxide nanocomposite: Thermal and flammability properties
F. Costa (2007)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar