Online citations, reference lists, and bibliographies.

Effect Of Fabrication Parameters On The Physiochemical Properties Of Amphiphilic Chitosan Nanoparticles

Marjan Motiei, S. Kashanian, A. H. Azandaryani
Published 2018 · Mathematics

Cite This
Download PDF
Analyze on Scholarcy
Share
The majority of anticancer drugs are hydrophobic and there is a big challenge to deliver them effectively to its target. One efficient way to overcome the challenge is to encapsulate them in an amphiphilic nanocarrier. This study will focus on the encapsulation of palmitic acid (PL) in chitosan nanoparticles by a two-step method, i.e., oil-in-water emulsion/ionic gelation technique to prepare amphiphilic chitosan nanoparticles (ACNs). Due to the importance of physicochemical characteristics of ACNs especially nanoparticle size on cell uptake, the present work has focused on the evaluation of some parameters’ effect such as, sonication power and time, cross-linker and stabilizer concentrations on ACNs size. The success of PL encapsulation was confirmed by Fourier transform infrared spectroscopy and the effect of the parameters were evaluated by laser light scattering and scanning electron microscopy. It was observed that each parameter affected nanoparticle size and morphology with an optimum limit. Thus, this study confirms the importance of preparation parameters on the physicochemical characteristics of ACNs.
This paper references
10.1016/0968-5677(96)00031-4
Supramolecular assembly of hydrophobized polysaccharides
K. Akiyoshi (1996)
10.1002/anie.201403036
Engineered nanoparticles for drug delivery in cancer therapy.
T. Sun (2014)
10.1016/J.PROGPOLYMSCI.2013.06.009
Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids
Mikael Larsson (2013)
10.1155/2011/196565
Improvement of Physicochemical Characteristics of Monoepoxide Linoleic Acid Ring Opening for Biolubricant Base Oil
Jumat Salimon (2011)
10.1208/pt050105
Two-stage optimization process for formulation of chitosan microspheres
R. R. Dubey (2008)
10.3390/md8020292
Chitins and Chitosans as Immunoadjuvants and Non-Allergenic Drug Carriers
R. Muzzarelli (2010)
10.1002/(SICI)1097-4628(19991114)74:7<1868::AID-APP32>3.0.CO;2-N
Chitosan–Polyelectrolyte complexation for the preparation of gel beads and controlled release of anticancer drug. I. Effect of phosphorous polyelectrolyte complex and enzymatic hydrolysis of polymer
F. L. Mi (1999)
10.1023/A:1016009313548
Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes
H. Takeuchi (2004)
10.1016/S0378-5173(02)00487-8
Preparation and characterization of chitosan microparticles intended for controlled drug delivery.
J. A. Ko (2002)
10.1016/S0169-409X(97)00120-8
Inclusion and release of proteins from polysaccharide-based polyion complexes.
Chornet (1998)
10.1016/S0021-9797(03)00069-9
Coalescence during emulsification. 2. Role of small molecule surfactants.
L. Lobo (2003)
10.1016/j.ejmech.2008.09.045
An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion.
S. Khoee (2009)
10.1016/j.colsurfb.2009.11.007
Encapsulation of ascorbyl palmitate in chitosan nanoparticles by oil-in-water emulsion and ionic gelation processes.
R. Yoksan (2010)
10.1023/A:1012128907225
Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines
P. Calvo (2004)
10.1016/J.CARBPOL.2009.12.040
Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications
Ashish Dev (2010)
10.4172/2157-7439.1000198
Influence of Lavander Essential Oil Addition on Passion Fruit Oil Nanoemulsions: Stability and In vivo Study
Rocha Filho Pa (2014)
CHEMICAL MODIFICATION OF CHITOSAN WITH FATTY ACIDS
E. Fray (2012)
10.1002/etc.2470
Cellular uptake of nanoparticles as determined by particle properties, experimental conditions, and cell type.
Katja Kettler (2014)
10.3390/molecules18010768
Effects of Selected Polysorbate and Sucrose Ester Emulsifiers on the Physicochemical Properties of Astaxanthin Nanodispersions
Navideh Anarjan (2013)
10.1111/J.2042-7158.1998.TB06185.X
Polymeric chitosan-based vesicles for drug delivery.
I. Uchegbu (1998)
10.1016/J.CARBPOL.2008.08.019
Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study
Wan Ajun (2009)
10.1016/j.ejpb.2013.12.018
Ionic polymeric micelles based on chitosan and fatty acids and intended for wound healing. Comparison of linoleic and oleic acid.
M. C. Bonferoni (2014)
10.1002/(SICI)1099-0488(19990715)37:14<1551::AID-POLB1>3.0.CO;2-H
Kinetic study of chitosan-tripolyphosphate complex reaction and acid-resistive properties of the chitosan-tripolyphosphate gel beads prepared by in-liquid curing method
F. Mi (1999)
10.1155/2011/852419
Epithelial Cell Coculture Models for Studying Infectious Diseases: Benefits and Limitations
B. L. Duell (2011)
10.1016/J.IJPHARM.2006.06.036
Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction.
F. Sonvico (2006)
10.1007/978-1-4899-0768-4_28
Chitosan: A Biocompatible Material for Oral and Intravenous Administrations
S. Hirano (1990)
10.1016/J.MSEA.2007.01.031
Effect of ultrasound sonication in carbon nanofibers/polyurethane foam composite
M. E. Kabir (2007)
10.1016/S0168-3659(97)00173-9
Preparation of chitosan self-aggregates as a gene delivery system.
K. Lee (1998)
10.5194/ACP-5-1951-2005
Impact of Palmitic Acid Coating on the Water Uptake and Loss of Ammonium Sulfate Particles
R. Garland (2005)
10.1016/S0378-5173(00)00403-8
A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery.
X. Shu (2000)
10.1007/978-3-642-20665-8
Encyclopedia of Colloid and Interface Science
T. Tadros (2013)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar