Online citations, reference lists, and bibliographies.

The Early Clinical History Of Salicylates In Rheumatology And Pain

T. Hedner, B. Everts
Published 2005 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The first clinical reports on the treatment of fever and pain with salicylate-containing natural willow bark remedies were made by the English clergyman Edward Stone in 1763. The pharmacologically active principles were isolated from natural sources by Italian, German and French scientists between 1826 and 1829. Salicylic acid was first synthesised by the German Gerland in 1852 and a year later the Frenchman Gerhardt synthesised acetylsalicylic acid. The first reports on the clinical use of salicylic acid in rheumatic disorders were made independently by the two German physicians Stricher and Reiss in 1876. Acetylsalicylic acid was rediscovered by Hoffmann in 1897 and by the turn of the century it had gained worldwide recognition in the treatment of pain and rheumatological disorders. Reports on adverse events relating to gastrointestinal intolerance and bleeding appeared early, but were largely neglected until the 1950s. Today, salicylates are still widely used as analgesic, antipyretic and anti-inflammatory drugs. New indications, such as thrombosis prophylaxis, have emerged during the last decades, and yet others are being explored.
This paper references
10.1038/newbio231232a0
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
J. Vane (1971)
Pharmakologisches ber Aspirin (Acetylsalicylsure)
H. Dreser
Experiences with aspirin (Acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis.
L. Craven (1953)
Aspirin in modern therapy: a review
ML Tainter (1969)
Aspirin , ein neues Salicylpr ~ parat
K Witthauer (1899)
10.1161/01.CIR.89.1.432
History of drugs for thrombotic disease. Discovery, development, and directions for the future.
R. Mueller (1994)
STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE XI. HYPOPROTHROMBINEMIA IN THE RAT INDUCED BY SALICYLIC ACID
K. P. Link (1943)
The Aspirin Wars: Money, Medicine and 100 Years of Rampant Competition
C. Mann (1993)
Prostaglandin synthetase 2
HR Herchman (1996)
10.5694/j.1326-5377.1968.tb83470.x
Gastric ulcer, duodenal ulcer and gastric carcinoma: a case-control study of certain social and environmental factors.
M. Gillies (1968)
An account of the success of the bark of the willow in the cure of agues
E. Stone (1952)
10.1016/S0140-6736(48)91585-2
Salicylic acid for coronary thrombosis?
P. Gibson (1948)
10.1093/ajcp/18.12.987a
The Salicylates, A Critical Bibliographic Review
W. Jetter (1948)
Acetylsalicylic acid, possible preventive of coronary thrombosis.
Craven Ll (1950)
10.1016/S0140-6736(00)78970-7
GASTROSCOPIC OBSERVATION OF THE EFFECT OF ASPIRIN AND CERTAIN OTHER SUBSTANCES ON THE STOMACH
A. H. Douthwaite (1938)
10.1016/S0140-6736(02)49509-8
THE TREATMENT OF ACUTE RHEUMATISM BY SALICIN.
T. Maclagan
10.1016/S0140-6736(49)91829-2
Aspirin in the treatment of vascular diseases.
P. Gibson (1949)
Prostaglandin synthetase 2. Biochim Biophys Acta 1996;1299:125-40
HR Herchman (1997)
10.1007/BF01255603
Upper gastrointestinal disease in rheumatoid arthritis
David C. H. Sun (2005)
Prevention of coronary and cerebral thrombosis.
L. Craven (1956)
Ueber Aspirin ( Acetylsalicys ~ ure )
J Wohlgemuth
Ueber wirkung der salicyls ~ iure auf die gessgrmutter
C Binz (1893)
10.1056/NEJM197405232902102
Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center.
M. Levy (1974)
Aus der Traubschen Klinik . Ueber die Resultate der behandlung der polyarthritis rheumatica mit Salicyls / ~ ure
F Stricker (1876)
Analgesic, antipyretics and antiinflammatory agents: drugs employed in the treatment of rheumatoid arthritis and gout
PA Insel (1990)
10.1016/S0022-3476(46)80130-6
The effect of salicylate administration on the prothrombin time.
C. Govan (1946)
The history of salicylate
Bywaters EGL (1963)
10.1111/j.1532-5415.1999.tb01916.x
Aspirin therapy.
J. E. Carlson (1999)



This paper is referenced by
10.1002/ptr.5126
Salicin, an extract from white willow bark, inhibits angiogenesis by blocking the ROS-ERK pathways.
Chang-Seok Kong (2014)
10.1093/qjmed/hcp015
Osteoarticular tuberculosis in patients with systemic lupus erythematosus.
B. Hodkinson (2009)
ditorial comment iomarkers of pain – Zemblanity ?
esa Kontinen (2013)
10.1016/j.phymed.2011.08.065
Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract.
Axel Freischmidt (2012)
10.1016/j.sjpain.2013.07.025
Biomarkers of pain – Zemblanity?
Vesa K. Kontinen (2013)
10.1007/s00011-013-0685-1
Effect of salicin on gut inflammation and on selected groups of gut microbiota in dextran sodium sulfate induced mouse model of colitis
N. Verma (2013)
10.1016/j.mayocp.2012.11.015
Topical analgesics in the management of acute and chronic pain.
C. Argoff (2013)
Non-steriodal anti-inflammatory drugs: Overview
Amitabh Gupta (2016)
Eine randomisierte, kontrollierte klinische Studie zur Wirksamkeit und Verträglichkeit eines standardisierten Weidenrindenextraktes in der Behandlung von Cox- und Gonarthrosen
C. Biegert (2003)
10.3109/19390211.2013.830680
An In Vivo Study Examining the Antiinflammatory Effects of Chamomile, Meadowsweet, and Willow Bark in a Novel Functional Beverage
Elaine M Drummond (2013)
A new family of gerosuppressant agents
J. Menéndez (2013)
10.1016/J.SEMARTHRIT.2005.01.011
Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects.
Arathi R Setty (2005)
10.1159/000481690
Pleiotropic Effects of White Willow Bark and 1,2-Decanediol on Human Adult Keratinocytes
Eleonora Bassino (2017)
10.23736/S0392-0488.17.05592-4
The anti-inflammatory and antioxidant properties of 1,2-decanediol and willow bark extract in lipopolysaccharide-stimulated keratinocytes.
R. Di Caprio (2017)
10.4081/REUMATISMO.2006.66
[The Italian contributions to the history of salicylates].
P. Marson (2006)
10.1080/15287394.2019.1711476
Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes
E. L. Maistro (2020)
10.1016/j.freeradbiomed.2012.12.006
Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans.
Atsushi Ishikado (2013)
10.1007/s10457-018-0315-6
Recent advances in the practical usages of some trees/shrubs as ingredient of poultry diets
Alireza Seidavi (2018)
Topical Sprays: Novel Drug Delivery System
Prakarsha Chavan (2016)
10.17352/ojpp.000013
Rheumatoid arthritis: Treatment evolution over the years
Pelechas Eleftherios (2020)
10.3109/08941939.2016.1149641
The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats
Mahşuk Taylan (2016)
Phytochemical And Antimicrobial Activity Investigation Of Nicandra Physaloides Gaertn (solanaceae)
N. Mukungu (2013)
10.1002/ptr.4753
Inhibition of proinflammatory biomarkers in THP1 macrophages by polyphenols derived from chamomile, meadowsweet and willow bark.
Elaine M Drummond (2013)
Delayed diagnosis: The experience of women with systemic lupus erythematosus in Atlanta, Georgia
Kendra Hatfield-Timajchy (2007)
10.4081/REUMATISMO.2010.148
[A short history of anti-rheumatic therapy. II. Aspirin].
G. Pasero (2010)
10.1007/978-3-319-43589-3_13
Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.
B. Guigas (2016)
10.3389/fimmu.2016.00206
Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals
D. Klessig (2016)
UNTERSUCHUNGEN ZUM WIRKMECHANISMUS DER PROCYANIDIN-INDUZIERTEN VASORELAXATION AN ISOLIERTEN ARTERIEN VOM SCHWEIN
Aurica-Maria Kaufeld (2015)
erbal Medications Commonly Used in the Practice f Rheumatology : Mechanisms of Action , Efficacy , nd Side Effects
rathi R. Setty (2005)
10.3171/FOC.2006.21.4.12
Natural antiinflammatory agents for pain relief in athletes.
J. Maroon (2006)
10.1155/2014/386953
The Study of Interactions between Active Compounds of Coffee and Willow (Salix sp.) Bark Water Extract
Agata Durak (2014)
Evaluation of the efficacy of a Chinese herbal medicine in the treatment of patients with osteoarthritis of the knee
Bin Hua (2011)
See more
Semantic Scholar Logo Some data provided by SemanticScholar