Online citations, reference lists, and bibliographies.

Enantiomeric Cannabinoids: Stereospecificity Of Psychotropic Activity

R. Mechoulam, J. Feigenbaum, N. Lander, M. Segal, T. Järbe, A. Hiltunen, P. Consroe
Published 2005 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
The 1,1-dimethylheptyl homolog of (−)-(3R,4R)-7-hydroxy-delta-6-tetrahydrocannabinol (compoundII) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).



This paper is referenced by
Cannabinoid Regulation of Serotonin 2A (5-HT 2A ) Receptor Signaling
J. M. Franklin (2013)
10.1016/j.toxlet.2010.06.002
Spice drugs as a new trend: mode of action, identification and legislation.
I. Vardakou (2010)
10.1023/A:1015526217332
Activation of Cannabinoid Receptors Decreases the Area of Ischemic Myocardial Necrosis
D. S. Ugdyzhekova (2004)
10.3408/JAFST.16.73
Comprehensive analytical methods of the synthetic cannabinoids appearing in the illicit drug market
K. Zaitsu (2011)
16. Acute Interventions for Acquired Brain Injury
Matthew J. Meyer (2013)
10.1007/s10517-005-0123-7
Selective cannabinoid receptor agonist HU-210 decreases pump function of isolated perfused heart: Role of cAMP and cGMP
L. Maslov (2005)
10.23907/2012.029
Synthetic Cannabinoid Use and Sudden Death
Robert Stoppacher (2012)
Cannabinoid Transmission in the Basolateral Amygdala Modulates Prefrontal Cortex and Ventral Hippocampal Activity
Brian Pereira (2018)
10.1016/j.ntt.2016.08.003
Prenatal cannabis exposure - The "first hit" to the endocannabinoid system.
K. Richardson (2016)
10.1016/J.CLIM.2006.11.002
CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents.
C. Lombard (2007)
Cell type specificity in CB1 antagonism
Remco T. Molenhuis (2011)
10.1002/9781118451281.CH8
Fifty years of ‘cannabinoid research’ and the need for a new nomenclature
Vincenzo di Marzo (2014)
10.1007/3-7643-7358-X_2
Cannabinoid Chemistry: An Overview
L. Hanuš (2005)
10.3390/brainsci8030040
The Effects of Cannabinoids on Executive Functions: Evidence from Cannabis and Synthetic Cannabinoids—A Systematic Review
Koby Cohen (2018)
10.1016/j.plipres.2011.01.001
Is lipid signaling through cannabinoid 2 receptors part of a protective system?
P. Pacher (2011)
10.1016/j.neuropharm.2013.07.022
Cannabinoids in disguise: Δ9-Tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles
J. Wiley (2013)
10.1002/CBDV.200790154
Discovery and Isolation of Anandamide and Other Endocannabinoids
L. Hanuš (2007)
10.1016/j.pbb.2005.02.015
The role of endocannabinoid transmission in cocaine addiction
J. Arnold (2005)
10.1007/164_2018_144
The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution.
Samuel D. Banister (2018)
10.1093/jat/bks095
Identification and structural elucidation of four cannabimimetic compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in seized products.
R. Denooz (2013)
Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
Afeef S. Husni (2012)
10.1007/s11101-004-1534-1
Cannabinoids in Models of Chronic Inflammatory Conditions
R. Mechoulam (2004)
10.21007/ETD.CGHS.2010.0122
Synthesis of novel cannabinoid ligands and their use as anti-glioma and anti-inflammatory agents
Steven N. Gurley (2010)
10.1002/9781118023150.CH8
Perceptual Drug Discriminative Aspects of the Endocannabinoid Signaling System in Animals And Man
T. Järbe (2011)
10.1016/j.pneurobio.2017.10.007
The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases
V. Chiurchiù (2018)
Activité constitutive et adressage axonal du récepteur cannabinoïque neuronal CB1
Christophe Leterrier (2006)
10.1016/bs.apha.2017.05.002
Cannabinoids in the Cardiovascular System.
W. S. Ho (2017)
10.5455/BCP.20141120022005
Synthetic Marijuana: A Recent Turmoil in Substance Abuse
Tahir Tellioglu (2014)
Application of Mass Spectrometry in Unravelling the Secrets of the Endocannabinoid System
M. Lehtonen (2015)
10.1016/j.cbpa.2009.04.616
Endocannabinoid chemical biology: a tool for the development of novel therapies.
S. Petrosino (2009)
Pharmacological analysis of cannabinoid receptor activity in isolated nerve-smooth muscle and epithelial preparations
R. Makwana (2007)
10.1134/S1062359007010049
Significance of cardiac cannabinoid receptors in regulation of cardiac rhythm, myocardial contractility, and electrophysiologic processes in heart
A. V. Krylatov (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar