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Enantiomeric Cannabinoids: Stereospecificity Of Psychotropic Activity

R. Mechoulam, J. Feigenbaum, N. Lander, M. Segal, T. Järbe, A. Hiltunen, P. Consroe
Published 2005 · Medicine, Chemistry

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The 1,1-dimethylheptyl homolog of (−)-(3R,4R)-7-hydroxy-delta-6-tetrahydrocannabinol (compoundII) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).

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