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Kinetics And Intestinal Absorption Of32P-EHDP In Man

A. Caniggia, C. Gennari
Published 1976 · Chemistry, Biology, Medicine

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The kinetics and intestinal absorption of disodium ethane-l-hydroxy-l,1 diphosphonate labelled with s2p (32P.EHDP) have been studied in man. In 10 volunteers, after oral administration of 40btCi of 32p-EHDP (using a carrier dose of 20 mg/kg EHDP), the 6-day fecal cumulative recoveries averaged 70 to 90% of the administered dose. In 7 additional subjects, 20/~Ci of 32P-EHDP (using a carrier dose of 100mg EHDP) were given intravenously. Plasma activity curves, urinary excretion and fecal recovery demonstrated that in 6 days 35 to 50% of the administered 3zp_ EHDP was excreted in the urine, whereas negligible amounts of tracer were found in the stools. A radio-chromatographic study of urine demonstrated that the radioactivity was present only in the form of 32p-EHDP. Retention (100%-total recovery) ranged from 50 to 65% of the dose in 6 days. A very rapid decline of plasma radioactivity was observed so that on the sixth day the radioactivity in plasma averaged 0.01 to 0.03% of dose per litre (rate constant k = 0.010 _+ 0.001) (Fig. 1). Our results are similar to those of Ricker and Saville obtained with t4C-EHDP [1]. They are compatible with the evidence that there is a weak intestinal transport mechanism for EHDP, a high rate of urinary excretion and a sustained retention within the body in a compartment outside the blood.
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