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Mitochondrial Control Of Caspase-dependent And -independent Cell Death

L. Pradelli, M. Bénéteau, J. Ricci
Published 2010 · Biology, Medicine

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Mitochondria control whether a cell lives or dies. The role mitochondria play in deciding the fate of a cell was first identified in the mid-1990s, because mitochondria-enriched fractions were found to be necessary for activation of death proteases, the caspases, in a cell-free model of apoptotic cell death. Mitochondrial involvement in apoptosis was subsequently shown to be regulated by Bcl-2, a protein that was known to contribute to cancer in specific circumstances. The important role of mitochondria in promoting caspase activation has therefore been a major focus of apoptosis research; however, it is also clear that mitochondria contribute to cell death by caspase-independent mechanisms. In this review, we will highlight recent findings and discuss the mechanism underlying the mitochondrial control of apoptosis and caspase-independent cell death.
This paper references
10.1101/GAD.1604407
Dissecting eIF4E action in tumorigenesis.
Hans-Guido Wendel (2007)
10.1038/sj.cdd.4402001
Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs
A. Verhagen (2007)
10.1038/cdd.2008.166
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
N. Moisoi (2009)
10.1038/cdd.2008.107
The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias
Y. Kamitsuji (2008)
10.2174/156652408783769580
Unique biology of Mcl-1: therapeutic opportunities in cancer.
M. Warr (2008)
10.1158/0008-5472.CAN-08-1189
p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies.
S. Hong (2009)
10.1016/S1097-2765(00)00136-2
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
T. Lindsten (2000)
A (2007) Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer
I Zlobec (2007)
10.1128/MCB.24.23.10289-10299.2004
Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release
Paula B. Deming (2004)
10.1016/J.MOLCEL.2007.10.019
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.
S. Braunstein (2007)
10.1016/S0960-9822(00)00728-4
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
P. Dijkers (2000)
10.1038/sj.cdd.4401787
EndoG is dispensable in embryogenesis and apoptosis
K. K. David (2006)
10.1038/ncb1123
Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex
J. I. Leu (2004)
10.1038/sj.onc.1207279
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis
C. Candé (2004)
10.1016/j.molcel.2008.04.005
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
G. Dewson (2008)
10.1158/1078-0432.CCR-06-2371
Lack of Apoptotic Protease Activating Factor-1 Expression and Resistance to Hypoxia-Induced Apoptosis in Cervical Cancer
C. Leo (2007)
10.1016/j.cell.2007.04.027
ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
H. Puthalakath (2007)
10.1016/S0092-8674(00)00009-X
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
A. Verhagen (2000)
10.1016/S0092-8674(00)81683-9
The Hallmarks of Cancer
D. Hanahan (2000)
10.1016/J.MOLCEL.2006.02.009
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.
U. Maurer (2006)
10.1016/S0092-8674(00)81477-4
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
R. Hakem (1998)
10.1073/pnas.2636393100
Endonuclease G is required for early embryogenesis and normal apoptosis in mice
J. Zhang (2003)
10.1152/PHYSREV.00013.2006
Mitochondrial membrane permeabilization in cell death.
G. Kroemer (2007)
10.1016/S0092-8674(00)81733-X
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
H. Yoshida (1998)
10.1016/j.tcb.2008.01.007
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
J. Chipuk (2008)
10.1016/S0092-8674(00)80849-1
Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis
K. Li (2000)
10.1126/SCIENCE.1098231
A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death
L. Li (2004)
10.1084/JEM.184.4.1331
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
S. Susin (1996)
10.1016/J.CCR.2006.10.006
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
M. Konopleva (2006)
10.1016/J.EJCA.2007.01.029
Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer.
I. Zlobec (2007)
10.1016/j.cell.2008.11.010
Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
J. Lovell (2008)
10.1038/nrm2308
The BCL-2 protein family: opposing activities that mediate cell death
R. Youle (2008)
10.1073/PNAS.0603950103
Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal.
D. Brown (2006)
10.1038/335440A0
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
D. Vaux (1988)
10.1038/35051606
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
M. Soengas (2001)
10.1038/cdd.2009.137
Novel roles for GAPDH in cell death and carcinogenesis
A. Colell (2009)
10.1083/jcb.200702134
BUB1 mediation of caspase-independent mitotic death determines cell fate
Y. Niikura (2007)
Smac mimetics and TNFalpha: a dangerous liaison?
Hao Wu (2007)
10.1016/S1097-2765(01)00214-3
PUMA, a novel proapoptotic gene, is induced by p53.
K. Nakano (2001)
10.1182/BLOOD.V98.2.414
Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
L. Jia (2001)
10.1016/J.CCR.2007.07.001
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.
J. Deng (2007)
10.1126/SCIENCE.1133289
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
S. Willis (2007)
10.1126/SCIENCE.288.5468.1053
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.
E. Oda (2000)
10.1016/j.cell.2007.10.042
Smac Mimetics and TNFα: A Dangerous Liaison?
Hao Wu (2007)
10.1038/ncb1575
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
C. Baines (2007)
10.1074/JBC.273.51.34272
Bcl-2 Prevents Caspase-independent Cell Death*
S. Okuno (1998)
10.1097/00029330-200703020-00007
XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer
M. Li (2007)
10.1038/356494A0
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
M. Hengartner (1992)
10.1016/S0092-8674(00)81476-2
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
K. Kuida (1998)
A (2007) ER stress triggers apoptosis by activating BH3-only protein
H Puthalakath (2007)
10.1038/nature06872
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons
Jyh-Rong Chao (2008)
10.1128/MCB.00265-08
Inhibition of Apoptosome Formation by Suppression of Hsp90β Phosphorylation in Tyrosine Kinase-Induced Leukemias
M. Kurokawa (2008)
10.7326/0003-4819-44-5-1045_2
CANCER CELLS
G. L. Miller (2006)
10.1016/S0092-8674(00)00008-8
Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition
C. Du (2000)
10.1038/35083620
Endonuclease G is an apoptotic DNase when released from mitochondria
L. Li (2001)
10.1182/BLOOD-2006-04-015149
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).
D. Chauhan (2007)
10.1002/(SICI)1097-0045(19990601)39:4<269::AID-PROS7>3.0.CO;2-F
Inhibition of caspase activity does not prevent the signaling phase of apoptosis in prostate cancer cells
S. Denmeade (1999)
10.1016/j.cell.2004.05.008
Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain
Jean-Ehrland Ricci (2004)
10.1083/JCB.153.2.319
Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process
N. Waterhouse (2001)
10.1038/SJ.THJ.6200549
XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis.
I. Tamm (2004)
10.1038/onc.2009.448
Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
L. Pradelli (2010)
10.1074/JBC.M402727200
BCL-2 Translation Is Mediated via Internal Ribosome Entry during Cell Stress*
K. W. Sherrill (2004)
10.1126/SCIENCE.1092734
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
J. Chipuk (2004)
10.1016/S0960-9822(99)80425-4
Interdigital cell death can occur through a necrotic and caspase-independent pathway
M. Chautan (1999)
10.1016/J.CELL.2007.03.045
GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation
A. Colell (2007)
10.1016/S1470-2045(07)70342-X
Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia.
J. Apperley (2007)
10.1128/MCB.25.1.294-302.2005
Generation and Characterization of Endonuclease G Null Mice
R. Irvine (2005)
10.1038/sj.cdd.4402291
The mitochondrial serine protease HtrA2/Omi: an overview
L. V. Walle (2008)
10.1038/onc.2008.311
Caspase-independent cell death: leaving the set without the final cut
S. W. Tait (2008)
10.1182/blood-2008-05-157842
Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells.
E. Hulleman (2009)
10.1016/j.molcel.2008.11.025
Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism.
N. Y. Fu (2009)
10.1038/nature07396
BAX Activation is Initiated at a Novel Interaction Site
E. Gavathiotis (2008)
10.1128/MCB.24.22.9848-9862.2004
Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice
L. M. Martins (2004)
10.1172/JCI28281
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
Victoria Del Gaizo Moore (2007)
10.1158/0008-5472.CAN-08-2731
Modulation of caspase-independent cell death leads to resensitization of imatinib mesylate-resistant cells.
V. Lavallard (2009)
10.1128/MCB.24.16.7003-7014.2004
Upstream Regulatory Role for XIAP in Receptor-Mediated Apoptosis
J. Wilkinson (2004)
A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.
L. Li (2004)
10.1038/sj.emboj.7601276
Dissociating the dual roles of apoptosis‐inducing factor in maintaining mitochondrial structure and apoptosis
E. Cheung (2006)
10.1016/j.molcel.2009.01.018
Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death.
S. Roy (2009)
10.1182/BLOOD-2003-05-1605
A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.
M. Okada (2004)



This paper is referenced by
10.1111/J.1476-5381.2011.01649_7.X
CATALYTIC RECEPTORS
S. Alexander (2011)
Notch3 signalling pathway in vascular smooth muscle cell growth and survival
Adem Sadli (2013)
10.1016/j.yjmcc.2020.03.011
MitoPlex: A targeted multiple reaction monitoring assay for quantification of a curated set of mitochondrial proteins.
Aleksandr Stotland (2020)
10.31768/2312-8852.2016.38(4):224-237
Molecular markers of apoptosis in cancer patients exposed to ionizing radiation: the post-Chornobyl view.
A. Philchenkov (2016)
10.1038/srep26722
A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo
G. Liu (2016)
10.1007/s00726-020-02843-2
Inhibition of EIF-5A prevents apoptosis in human cardiomyocytes after malaria infection
Annette Kaiser (2020)
10.3389/fcimb.2012.00095
Programmed cell death in Leishmania: biochemical evidence and role in parasite infectivity
S. Gannavaram (2012)
10.1016/j.jep.2020.113168
In vitro cultured calculus bovis attenuates cerebral ischaemia-reperfusion injury by inhibiting neuronal apoptosis and protecting mitochondrial function in rats.
F. Lu (2020)
10.1201/B12279-6
Cellular and Molecular Processes of Neuronal Damage and Mechanisms in Neuroprotection and Neuroregeneration— Focus on Brain Ischemia
Gregor Zündorf (2012)
10.15414/jmbfs.2019.8.4.1021-1025
INFLUENCE OF NEW POLYPHENOL COMPOUND FROM EUPHORBIA PLANT ON MITOCHONDRIAL FUNCTION
Ulugbek Gayibov (2019)
10.1007/978-94-007-4138-6_9
Cellular Consequences of mtDNA-Encoded Mutations in NADH:Ubiquinone Oxidoreductase
Mina Pellegrini (2012)
10.1111/j.1476-5381.2011.01649_2.x
Consultants
S. Alexander (2011)
10.1186/1475-2867-14-56
Specific growth suppression of human cancer cells by targeted delivery of Dictyostelium mitochondrial ribosomal protein S4
Junji Chida (2014)
10.1074/jbc.M113.507210
Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) Is Regulated by Store-operated Ca2+ Entry and Mediates Cytoprotection against Necrotic Cell Death*
D. Brickley (2013)
Epigenetic modification of mitochondrial genes in Alzheimer's disease (AD)
Matthew Devall (2017)
10.18257/RACCEFYN.408
Estrategias de investigación para el tratamiento de Alzheimer con antioxidantes polifenólicos
Ligia Sierra (2016)
10.1038/s41419-020-2459-3
Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells
Xiaorui Yang (2020)
10.1155/2012/396573
Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells
Tzuu-Yuan Huang (2012)
10.1039/c4fo00168k
Differential effects of lipid fractions from silver carp brain on human cervical carcinoma cells in vitro.
C. Wang (2014)
10.3760/cma.j.issn.0366-6999.20131104
Protectin D1 promotes resolution of inflammation in a murine model of lipopolysaccharide‐induced acute lung injury via enhancing neutrophil apoptosis
X. Li (2014)
10.3892/ijo.2011.1135
Deciphering the role of paclitaxel in the SKGT4 human esophageal adenocarcinoma cell line.
S. J. Kim (2011)
10.7150/ijbs.9719
Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis
Haijian Wu (2014)
10.1038/s41598-018-32491-2
Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity
Amber Kaminski (2018)
n situ apoptosis of adaptive immune cells and the cellular escape of rabies virus n CNS from patients with human rabies transmitted by Desmodus rotundus laine
R. M. T. Fernandesa (2011)
10.1007/s11302-015-9471-6
Supportive or detrimental roles of P2Y receptors in brain pathology?—The two faces of P2Y receptors in stroke and neurodegeneration detected in neural cell and in animal model studies
Daniel F. Förster (2015)
10.1007/s10495-017-1403-1
Erratum to: A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells
Chih-Wei Chen (2017)
10.1016/j.jalz.2016.09.003
Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease
D. Mastroeni (2017)
The neuroprotective actions of quercetin
Nsoh Tabien (2010)
10.1038/s41598-017-10041-6
Zinc depletion promotes apoptosis-like death in drug-sensitive and antimony-resistance Leishmania donovani
S. Saini (2017)
10.2478/s11658-014-0183-7
Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells
E. Wolmarans (2014)
10.1007/s11010-013-1593-y
NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer
V. Vaish (2013)
10.3390/insects11090647
Bmapaf-1 is Involved in the Response against BmNPV Infection by the Mitochondrial Apoptosis Pathway.
Xue-yang Wang (2020)
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