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Lipoprotein Lipase: Structure, Function, Regulation, And Role In Disease

J. R. Mead, S. A. Irvine, D. Ramji
Published 2002 · Medicine, Biology

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Abstract. Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation. Research carried out over the past two decades have not only established a central role for LPL in the overall lipid metabolism and transport but have also identified additional, non-catalytic functions of the enzyme. Furthermore, abnormalities in LPL function have been found to be associated with a number of pathophysiological conditions, including atherosclerosis, chylomicronaemia, obesity, Alzheimer's disease, and dyslipidaemia associated with diabetes, insulin resistance, and infection. Advances have also been made in relating the various domains in the protein to different functions, and in understanding the mechanisms that are responsible for the changes in LPL expression seen in response to nutritional and other physiological changes, and during disease. This review summarises recent findings in relation to the structure, function, and regulation of LPL along with its important role in disease.
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Metabolism pathways in chronic lymphocytic leukemia
U. Rozovski (2016)
Adiponectin increases LPL activity via RhoA/ROCK-mediated actin remodelling in adult rat cardiomyocytes.
Riya Ganguly (2011)
Differential Effects of Lipoprotein Lipase on Tumor Necrosis Factor-α and Interferon-γ-mediated Gene Expression in Human Endothelial Cells*
R. S. Kota (2005)
Tissue leptin and plasma insulin are associated with lipoprotein lipase activity in severely obese patients.
J. Ramis (2005)
Lipoprotein Lipase, Tissue Expression and Effects on Genes Related to Fatty Acid Synthesis in Goat Mammary Epithelial Cells
W. Zhao (2014)
Changes of vitellogenin and Lipase in captive Sterlet sturgeon Acipenser ruthenus females during previtellogenesis to early atresia
S. R. Akhavan (2015)
An Insulin-response Element-binding Protein That Ameliorates Hyperglycemia in Diabetes*
B. C. Villafuerte (2005)
Comparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism.
R. Holmes (2011)
NaKtide Targeted to Adipocytes Ameliorates Western Diet Induced Obesity
R. Pratt (2019)
Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity
V. Sukonina (2007)
Protein-Protein interactions uncover candidate ‘core genes’ within omnigenic disease networks
Abhirami Ratnakumar (2020)
Bacterial lipolysis of immune-activating ligands promotes evasion of innate defenses
X. Chen (2019)
Molecular mechanisms underlying the effects of CB1 antagonism in canine model of obesity
Malini S. Iyer (2009)
A role for CEACAM2 in insulin homeostasis and action
Payal R. Patel (2010)
Integrative genetic and epigenetic studies to identify prostate cancer genes at chromosome 8p
Yu Dong Cheng (2011)
Wide-gene expression analysis of lipid-relevant genes in nutritionally challenged gilthead sea bream (Sparus aurata).
L. Benedito-Palos (2014)
Association between polymorphisms of lipoprotein lipase gene and chicken fat deposition
R. Liu (2006)
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