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The Effects Of Bethanechol And Cisapride On Urodynamic Parameters In Patients Undergoing Radical Hysterectomy For Cervical Cancer. A Randomized, Double-blind, Placebo-controlled Study

A. Madeiro, A. C. Rufino, M. Sartori, E. Baracat, G. R. Lima, M. Girão
Published 2005 · Medicine

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To evaluate the effects of bethanechol and cisapride on urodynamic parameters in patients undergoing radical hysterectomy for cervical cancer. In this double-blind, placebo-controlled study, 79 patients with cervical cancer were randomized to receive bethanechol (30 mg/day), cisapride (30 mg/day), bethanechol combined with cisapride (same doses) and placebo. Urodynamic study was performed, including flowmetry, cystometry, pressure-flow study and urethral pressure profile before radical hysterectomy. Medication was administered postoperatively during 30 days. At the end of this period, urodynamic evaluation was repeated. There was an increase in both the maximum cystometric capacity and bladder capacity at first desire to void in the placebo group compared to the other groups. The rate of detrusor instability was higher in the group that used bethanechol combined with cisapride. Detrusor pressure at maximum flow was significantly higher when cisapride was used. There was a significant increase in postvoid residual volume in the placebo group. In patients undergoing radical hysterectomy, bethanechol and cisapride determined lower cystometric capacity and decreased bladder capacity at first desire to void, a higher maximum flow rate and higher detrusor pressure at maximum flow, with lower postvoid residual volumes. The early use of bethanechol and cisapride after radical hysterectomies positively modified urodynamic parameters, determining a more efficient detrusor function.
This paper references
Radicality of parametrial resection and dysfunction of the lower urinary tract after radical hysterectomy.
G. Ralph (1991)
10.1254/JJP.76.109
Effect of muscarinic agonist on overflow incontinence induced by bilateral pelvic nerve transection in rats.
I. Hirotsu (1998)
Observations on bladder function following radical hysterectomy using carbon dioxide cystometry.
Roberts Jm (1978)
10.1016/S0022-5347(17)55465-8
The effects of bethanechol chloride on urodynamic parameters in normal women and in women with significant residual urine volumes.
A. Wein (1980)
10.1016/S0090-4295(02)02243-4
The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society.
P. Abrams (2002)
10.1038/sc.1995.132
The effects of 4 weeks treatment with cisapride on cystometric parameters in spinal cord injury patients. A double-blind, placebo controlled study
J. Wyndaele (1995)
10.1016/S0022-5347(17)56599-4
Further observations on the cystometric and uroflowmetric effects of bethanechol chloride on the human bladder.
L. P. Sonda (1979)
10.1006/GYNO.2002.6614
Urinary tract dysfunction after radical hysterectomy for cervical cancer.
G. Chen (2002)
10.1016/S0022-5347(17)54271-8
Detrusor hypertonicity as a late complication of a Wertheim hysterectomy.
J. Woodside (1982)
10.1016/0002-9378(81)90551-2
The effect of Wertheim hysterectomy upon bladder and urethral function.
J. Low (1981)
10.5694/J.1326-5377.1994.TB138353.X
Urinary disorders associated with cisapride
I. Rohan (1994)
10.1007/BF02764845
Prophylaxis and treatment of bladder dysfunction after Wertheim-Meigs operation: the positive effect of early postoperative detrusor stimulation using the cholinergic drug betanecholchloride
B. Kemp (2007)
10.1067/MOB.2002.125704
The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society.
P. Abrams (2003)
10.1016/S0022-5347(17)47234-X
Is bethanechol chloride clinically effective in promoting bladder emptying? A literature review.
A. Finkbeiner (1985)
10.1016/0002-9378(73)90092-6
Bladder dysfunction following Schauta hysterectomy.
J. Roman-Lopez (1973)
10.1016/0002-9378(80)90132-5
The effect of radical hysterectomy on bladder physiology.
J. P. Forney (1980)
10.1002/NAU.10052
The standardisation of terminology of lower urinary tract function: Report from the standardisation sub‐committee of the International Continence Society
P. Abrams (2002)
10.1067/MOB.2001.116367
A randomized, double-blind placebo-controlled trial of the effects of the 5-hydroxytriptamine(4) agonist cisapride on the female urinary bladder.
A. Steele (2001)
Urodynamic Changes in Urethrovesical Function After Radical Hysterectomy
R. J. Scotti (1986)
10.1111/j.1476-5381.1994.tb16163.x
Characterization of the 5‐HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle
M. Tonini (1994)
10.3109/00016348909028668
Radical Hysterectomy And The Function Of The Lower Urinary Tract: Urodynamic Quantification Of Changes In Storage And Evacuation Function
H. Vervest (1989)
10.1038/sc.1993.22
Effects of cisapride on anorectal and vesicourethral function in spinal cord injured patients
R. Carone (1993)
10.1097/00006254-197503000-00027
Five Classes of Extended Hysterectomy for Women With Cervical Cancer
M. Piver (1974)
10.1016/0090-8258(82)90029-4
Voiding disorders after radical hysterectomy.
L. Carenza (1982)
Ureteral Assessment After Radical Hysterectomy
D. Larson (1987)
10.1016/S0020-7292(98)00158-1
Abnormal urodynamic findings after radical hysterectomy or pelvic irradiation for cervical cancer
H. Lin (1998)



This paper is referenced by
10.1002/nau.20723
Effect of lumbar epidural administration of neostigmine on lower urinary tract function
M. Agarwal (2010)
10.1016/j.critrevonc.2008.09.003
Nerve-sparing radical hysterectomy for cervical carcinoma.
P. Dursun (2009)
10.1007/S11608-008-0198-5
Troubles urinaires associés au traitement chirurgical de l’endométriose profonde: intérêt de la chirurgie avec préservation nerveuse
G. Dubernard (2008)
10.1097/SPV.0B013E31819CDF54
Postoperative Voiding Dysfunction in Women
D. Patterson (2009)
10.1007/S11608-009-0259-4
Troubles fonctionnels après chirurgie de l’endométriose profonde
C. Huissoud (2009)
La voie combinée vaginale-coelioscopique dans les endométrioses profondes avec large infiltration vaginale et prévention de l'atonie vésicale post-opératoire
E. Desnyder (2017)
10.1016/j.anclin.2009.07.010
Postoperative urinary retention.
Daniela M. Darrah (2009)
10.1111/j.1440-1746.2009.05780.x
Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract
T. Hiyama (2009)
Postoper ative Urinary Retention
Daniela M. Darrah (2009)
10.1007/978-3-642-23274-9_16
Muscarinic agonists and antagonists: effects on the urinary bladder.
Donna J. Sellers (2012)
10.1007/s11884-014-0253-8
Voiding Dysfunction After Non-genitourinary Radical Pelvic Surgery
Thomas R. Jarvis (2014)
10.1007/978-3-319-23687-2_6
Current Drug Therapy for Underactive Bladder
M. Chancellor (2016)
10.1111/luts.12166
Effects of an EP2 and EP3 Receptor Dual Agonist, ONO‐8055, on a Radical Hysterectomy‐Induced Underactive Bladder Model in Monkeys
H. Matsuya (2018)
10.1016/J.JGYN.2014.03.003
Troubles fonctionnels urinaires liés à l’endométriose profonde et à son traitement : revue de la littérature
L. Campin (2014)
10.1016/j.autneu.2013.02.020
Effects of the 5-HT4 receptor agonist, cisapride, on neuronally evoked responses in human bladder, urethra, and ileum
F. Kullmann (2013)
10.1111/IGC.0b013e3181f7d6de
Bethanechol Chloride for the Prevention of Bladder Dysfunction After Radical Hysterectomy in Gynecologic Cancer Patients: A Randomized Controlled Trial Study
T. Manchana (2010)
10.1007/S11608-007-0126-0
Traitement médical de l’hypoactivité vésicale
M. Sèze (2007)
10.1002/14651858.CD012863
Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage cervical cancer
Apiwat Aue-aungkul (2017)
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