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Mild Steel Welding Is Associated With Alterations In Circulating Levels Of Cancer-related Proteins

A. Gliga, Tahir Taj, M. Hedmer, E. Assarsson, L. Rylander, María C. Albin, K. Broberg
Published 2019 · Medicine

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Welding fumes were recently classified as carcinogenic to humans and worldwide millions work as welders or perform welding operations. The purpose of this study was to identify new biomarkers of welding-induced carcinogenesis. We evaluated a panel of 91 putative cancer-related proteins in serum in a cohort of welders working with mild steel (n = 77) and controls (n = 94) from southern Sweden sampled on two occasions 6-year apart using a longitudinal analysis (linear mixed models). The significant results from the longitudinal analysis were tested for reproducibility in welders (n = 88) and controls (n = 69) sampled once during the same sampling period as timepoint 1 or timepoint 2 (linear regression models), i.e., in a cross-sectional setting. The models were adjusted for age, body-mass index, and use of snus. All study participants were non-smokers at recruitment. Exposure to welding fumes was assessed using questionnaires and respirable dust measurement in the breathing zone that was adjusted for personal respiratory protection equipment. The median respirable dust in welders was 0.7 (0.2–4.2) and 0.5 (0.1–1.9) mg/m3 at the first and second timepoints, respectively. We identified 14 cancer-related proteins that were differentially expressed in welders versus controls in the longitudinal analysis, out of which three were also differentially expressed in the cross-sectional analysis (cross-sectional group). Namely, syndecan 1 (SDC1), folate receptor 1 (FOLR1), and secreted protein acidic and cysteine rich (SPARC) were downregulated, in welders compared with controls. In addition, FOLR1 was negatively associated with years welding. Disease and function analysis indicated that the top proteins are related to lung cancer as well as cell invasion and migration. Our study indicates that moderate exposure to welding fumes is associated with changes in circulating levels of putative cancer-related proteins, out of which FOLR1 showed a clear dose–response relationship. It is, however, unclear to which extent these changes are adaptive or potential early biomarkers of cancer.
This paper references
Conditions Associated with Circulating Tumor-Associated Folate Receptor 1 Protein in Healthy Men and Women
L. Kelemen (2014)
Antithetic roles of proteoglycans in cancer
Elena Garusi (2011)
Exposure to welding fumes is associated with acute systemic inflammatory responses
J. Kim (2005)
Welding fume exposure is associated with inflammation: a global metabolomics profiling study
S. Shen (2018)
Systemic inflammatory responses following welding inhalation challenge test
P. Kauppi (2015)
Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
T. Szatmári (2015)
Serum syndecan-1: a new independent prognostic marker in multiple myeloma.
C. Seidel (2000)
Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression
A. Kurosaki (2016)
SPARC correlates with unfavorable outcome and promotes tumor growth in lung squamous cell carcinoma.
Juqing Xu (2019)
Are welders more at risk of respiratory infections? Findings from a cross-sectional survey and analysis of medical records in shipyard workers: the WELSHIP project
A. Marongiu (2016)
Lung tumor promotion by chromium-containing welding particulate matter in a mouse model
P. Zeidler-Erdely (2013)
Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation.
Romuald Contzler (2005)
Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer.
H. Joensuu (2002)
Welding, a risk factor of lung cancer: the ICARE study
M. Matrat (2016)
The α folate receptor is highly activated in malignant pleural mesothelioma
R. Bueno (2001)
A Cross-Sectional Study of the Cardiovascular Effects of Welding Fumes
H. Li (2015)
The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease
Sharon L Wong (2017)
Relation between biomarkers in exhaled breath condensate and internal exposure to metals from gas metal arc welding.
F. Hoffmeyer (2012)
Risk of lung cancer according to mild steel and stainless steel welding.
Anita Rath Sørensen (2007)
Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer
F. Andriani (2018)
Exposure to iron and welding fumes and the risk of lung cancer.
Sie Sie Siew (2008)
Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy.
H. Elnakat (2004)
The heparanase/syndecan‐1 axis in cancer: mechanisms and therapies
Vishnu C. Ramani (2013)
Impact of Different Welding Techniques on Biological Effect Markers in Exhaled Breath Condensate of 58 Mild Steel Welders
F. Hoffmeyer (2012)
Kunskapssammanställning. Hälsoeffekter av gaser och partiklar bildade vid svetsning
B Sjögren (2013)
Pneumococcal infection of respiratory cells exposed to welding fumes; Role of oxidative stress and HIF-1 alpha
J. Grigg (2017)
Exposure to welding fumes is associated with hypomethylation of the F2RL3 gene: a cardiovascular disease marker
M. B. Hossain (2015)
Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance
D. J. O'Shannessy (2012)
Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance
Michelle A. Sugimoto (2016)
Correlates of oxidative stress and free-radical activity in serum from asymptomatic shipyard welders.
S. G. Han (2005)
Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability
Erika Assarsson (2014)
Kunskapssammanställning. Hälsoeffekter av gaser och partiklar bildade vid svetsning
B Sjögren (2013)
F2RL3 methylation, lung cancer incidence and mortality
Y. Zhang (2015)
Evaluation of New Biomarkers in the Prediction of Malignant Mesothelioma in Subjects with Environmental Asbestos Exposure
Melike Demir (2016)
Global Gene Expression Profiling in Whole-Blood Samples from Individuals Exposed to Metal Fumes
Z. Wang (2005)
Exposure to respirable dust and manganese and prevalence of airways symptoms, among Swedish mild steel welders in the manufacturing industry
M. Hedmer (2013)
Oxidative stress, telomere shortening, and DNA methylation in relation to low‐to‐moderate occupational exposure to welding fumes
H. Li (2015)
Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide.
N. Guha (2017)
Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff
Anneli Sundkvist (2018)
The alpha folate receptor is highly activated in malignant pleural mesothelioma.
R. Bueno (2001)
Welding and lung cancer in Central and Eastern Europe and the United Kingdom.
A. '. 't Mannetje (2012)

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